Terbinafine 250mg & Itraconazole 100mg: The Ultimate Solution for Stubborn Fungal Infections Steris Healthcare.

Fungal infections affect millions of people worldwide. From athlete’s foot to stubborn nail fungus, these infections can be itchy, embarrassing, and difficult to treat. Two of the most powerful weapons in the fight against fungal pathogens are Terbinafine and Itraconazole. At CONARIS, we’ve combined these two potent antifungals into our premium product — CONARIS T100 — offering patients a reliable, effective, and convenient solution for a wide range of fungal infections.

In this comprehensive guide, we’ll dive deep into everything you need to know about Terbinafine 250 mg and Itraconazole 100 mg, how CONARIS T100 leverages both, when to use each medication, side‑effects, dosage, and much more!

What is CONARIS T100?

CONARIS T100 is a high‑quality, pharmaceutical‑grade brand developed by CONARIS Health Solutions. Each pack contains two distinct tablets:

1. Terbinafine 250 mg – for dermatophyte infections (skin, hair, nails).
2. Itraconazole 100 mg – for systemic and non‑dermatophyte fungal infections.

Our manufacturing follows GMP (Good Manufacturing Practices), ensuring safety, purity, and maximum efficacy.

Understanding Fungal Infections

Fungal infections (mycoses) are caused by pathogenic fungi. They’re categorized by location:

1. Superficial – Affect skin, hair, nails (e.g., athlete’s foot, ringworm, jock itch).
2. Subcutaneous – Enter skin through cuts (e.g., sporotrichosis).
3. Systemic – Affect internal organs (e.g., histoplasmosis, blastomycosis).

Common culprits:

• Trichophyton spp. (dermatophytes)
• Candida spp. (yeast)
• Aspergillus spp.

Terbinafine 250 mg in CONARIS T100

Mechanism of Action

Terbinafine inhibits the fungal enzyme squalene epoxidase. This causes toxic buildup of squalene and depletion of ergosterol — a vital component of fungal cell membranes. Without ergosterol, the fungal cell wall ruptures → cell death.

Primary Uses

• Dermatophyte infections:
  • Athlete’s foot (tinea pedis)
  • Ringworm (tinea corporis)
  • Jock itch (tinea cruris)
  • Scalp ringworm (tinea capitis)
• Onychomycosis (nail fungus) – FIRST‑LINE TREATMENT!

Dosage (CONARIS T100 Terbinafine 250 mg)

• Skin infections: 250 mg once daily for 2–6 weeks.
• Nail infections:
  • Fingernails: 250 mg once daily for 6 weeks.
  • Toenails: 250 mg once daily for 12 weeks.

Take with or without food.

Why Terbinafine is Preferred for Nail Fungus?

• Higher cure rates (70‑80%) compared to other antifungals.
• Short treatment duration.
• Low recurrence rate.

Pharmacokinetics

• Absorption: ~40% bioavailable.
• Half‑life: 200–300 hours. Accumulates in skin & nails → long‑lasting effect.

Side Effects 

Important: Liver function tests (LFTs) are recommended before and during treatment.

Itraconazole 100 mg in CONARIS T100

Mechanism of Action

Itraconazole blocks the fungal enzyme lanosterol 14α‑demethylase, halting ergosterol synthesis. This damages the cell membrane, killing the fungus.

Primary Uses

• Onychomycosis (especially non‑dermatophyte molds).
• Systemic mycoses:
  • Histoplasmosis
  • Blastomycosis
  • Aspergillosis
• Candidiasis (systemic or oral).
• Sporotrichosis.

Dosage (CONARIS T100 Itraconazole 100 mg)

Two dosing regimens:

1. Continuous Therapy:

• 100 mg twice daily for 2–4 weeks (skin infections).

1. Pulse Therapy (Ideal for nail infections):

• 200 mg twice daily (400 mg/day) for 1 week per month.
• Fingernails: 3 pulses (3 months total).
• Toenails: 4 pulses (4 months total).

MUST be taken with FOOD (especially a fatty meal) — improves absorption dramatically!

Pharmacokinetics

• Bioavailability: Highly variable. Food increases absorption by 2–4×!
• Half‑life: ~21 hours (active metabolite: 36 hours).

Side Effects

Contraindications:

• Congestive Heart Failure (CHF).
• Severe liver disease.

Terbinafine vs. Itraconazole: Which Should You Use?

Rule of Thumb:
For common skin/nail infections caused by dermatophytes → Terbinafine (CONARIS T100).
For rare molds, systemic infections, or if dermatophyte test is negative → Itraconazole (CONARIS T100).

Can Terbinafine & Itraconazole Be Taken Together?

Generally, NO. They target similar pathways, and combining them raises toxicity risk. CONARIS T100 offers them as separate tablets — you use only one based on your doctor’s prescription.

Drug Interactions

Terbinafine 250 mg

Very low interaction potential. Minor interactions with:

• Caffeine (may increase levels)
• Rifampin (reduces terbinafine levels)

Itraconazole 100 mg (CYP3A4 Inhibitor!)

AVOID concurrent use with:

• Statins (e.g., Simvastatin, Lovastatin) → risk of rhabdomyolysis.
• Anticoagulants (Warfarin) → increased bleeding risk.
• Anti‑arrhythmics (e.g., Quinidine)
• Antacids (reduce absorption)
• Certain antibiotics (e.g., Clarithromycin)

Always inform your doctor about ALL medications you’re taking!

Special Populations

1. Pregnancy & Breastfeeding
   Both drugs are Category C. Use only if benefits outweigh risks.

2. Pediatric Use

• Terbinafine: Safe for ≥2 years (dose based on weight).
• Itraconazole: Safe for ≥3 years.

1. Elderly Patients
   Use with caution; monitor liver function closely.

2. Hepatic Impairment
   DO NOT USE either drug unless absolutely necessary.

3. Renal Impairment
   No dosage adjustment needed for either drug.

Monitoring During Treatment

1. Baseline LFTs before starting therapy.
2. Repeat LFTs after 4–6 weeks of treatment.
3. If liver enzymes rise > 3× the upper limit → STOP medication.

Why Choose CONARIS T100?

Premium Quality – Manufactured in WHO‑approved facilities.
Accurate Potency – Each tablet delivers exactly 250 mg (Terbinafine) or 100 mg (Itraconazole).
Affordable – Same efficacy as brand‑names at a fraction of the cost.
Patient Trust – Thousands of satisfied users across India.

Conclusion

Fungal infections shouldn’t rule your life! With CONARIS T100, you have access to two of the most effective antifungal agents available today. Whether you’re battling stubborn nail fungus or a systemic infection, Terbinafine 250 mg and Itraconazole 100 mg — crafted with precision in CONARIS T100 — offer a safe, reliable, and fast‑acting solution.

Frequently Asked Questions 

Q1. How soon will I see improvement?
A: Skin infections improve within 1–2 weeks. Nail infections take months (nails grow slowly!).

Q2. Can I drink alcohol while taking CONARIS T100?
A: Moderate alcohol is generally safe, but avoid excess as it stresses the liver.

Q3. What if I miss a dose?
A: Take it as soon as you remember. If it’s near the next dose, skip the missed one — never double dose.

Q4. Can diabetics use CONARIS T100?
A: Yes. No sugar content.

Q5. Is a prescription required?
A: Yes. Antifungals require medical supervision.

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