"ROXARIVABEN 20: Rivaroxaban 20mg for Anticoagulation"

Introduction

ROXARIVABEN 20 contains Rivaroxaban 20 mg, a next-generation oral anticoagulant belonging to the class of direct Factor Xa inhibitors. Developed as a more convenient and safer alternative to traditional anticoagulants, Rivaroxaban offers fixed dosing without routine INR monitoring, making it an ideal choice for long-term use in preventing and treating venous and arterial thromboembolic disorders.

Composition

• Active Ingredient: Rivaroxaban 20 mg

• Brand Name: ROXARIVABEN 20

• Form: Oral tablet

• Category: Anticoagulant / Cardiovascular

Mechanism of Action

Rivaroxaban selectively inhibits Factor Xa, a key enzyme in the coagulation cascade that converts prothrombin to thrombin. By blocking Factor Xa, it:

• Prevents fibrin clot formation

• Reduces the risk of deep vein thrombosis (DVT), pulmonary embolism (PE), and stroke

• Provides rapid onset and predictable anticoagulant effect

Indications & Uses

ROXARIVABEN 20 is commonly used for:

• Treatment of deep vein thrombosis (DVT)

• Treatment and prevention of pulmonary embolism (PE)

• Stroke prevention in non-valvular atrial fibrillation (NVAF)

• Postoperative thromboprophylaxis after knee or hip replacement surgery

• COVID-19 associated coagulopathy (under specific clinical protocols)

Rivaroxaban Dose for DVT

• Treatment dose: Rivaroxaban 15 mg twice daily for the first 21 days, followed by 20 mg once daily (ROXARIVABEN 20) for maintenance.

Rivaroxaban Dose in COVID

In patients recovering from moderate to severe COVID-19 with elevated D-dimer or coagulopathy risk, rivaroxaban 10–20 mg once daily may be prescribed as part of extended thromboprophylaxis, under strict medical supervision.

Note: Off-label use in COVID-19 should follow updated clinical guidelines and physician discretion.

Rivaroxaban Synthesis (Brief Insight)

Rivaroxaban is synthesized using a multi-step chemical process involving:

• Formation of an oxazolidinone core

• Introduction of a morpholinone ring

• Coupling with specific aromatic intermediates to form the selective Factor Xa inhibitor

It is a non-vitamin K antagonist with high oral bioavailability and a half-life of 5–13 hours.

Dosage & Administration

• Usual Maintenance Dose: 20 mg once daily with food

• For Renal Impairment: Adjusted dose or alternative therapy based on creatinine clearance

• Always follow physician instructions and monitor for bleeding

Side Effects

Common side effects of Rivaroxaban include:

• Increased risk of bleeding (nosebleeds, GI bleeding, or bruising)

• Anemia

• Dizziness or fatigue

• Rare: Liver enzyme elevations or allergic reactions

Precautions

• Avoid use in patients with active bleeding or bleeding disorders

• Use cautiously in patients with severe renal or hepatic impairment

• Avoid concurrent use with other anticoagulants or NSAIDs

• Not recommended in pregnancy or breastfeeding unless advised by a doctor

Storage Instructions

• Store at room temperature, below 25°C

• Protect from moisture and sunlight

• Keep out of reach of children

Why Choose ROXARIVABEN 20 by Steris Healthcare?

• High-purity Rivaroxaban formulation

• Produced in WHO-GMP certified facilities

• Trusted by cardiologists and vascular specialists across India

• Backed by Steris Healthcare's reputation for affordable, effective care

FAQs

1. Can ROXARIVABEN 20 be taken on an empty stomach?

It is recommended to take it with food to improve absorption and reduce gastric discomfort.

2. Is monitoring required with Rivaroxaban?

Routine INR or aPTT monitoring is not required. However, renal function and signs of bleeding should be checked periodically.

3. What if I miss a dose?

Take it as soon as you remember. If it's close to your next dose, skip the missed one—never double the dose.

Conclusion

ROXARIVABEN 20 provides a powerful and convenient solution for patients needing long-term anticoagulation. With its once-daily dosing and proven efficacy in preventing DVT, PE, and stroke, it stands as a modern alternative to older therapies. Trust Steris Healthcare's ROXARIVABEN 20 to help you manage clot-related risks safely and effectively.

About The Author

STERIS HEALTHCARE PVT LTD

Steris Healthcare Pvt Ltd, known as Sterispharma, was founded in February 2018 by a team of experienced professionals in the pharmaceutical industry. Headquartered in Navi Mumbai, the company holds certifications from WHO, GMP, and ISO, reflecting its dedication to maintaining high standards of quality and safety. Sterispharma’s mission is to provide affordable, high-quality medications across India, strictly adhering to WHO guidelines. With the convenience of an online pharmacy, customers can easily order medicines with home delivery options.

For further information 

Email: info@sterispharma.com / contact@sterispharma.com

Call/WhatsApp: 8209542042 , 8824175417

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