MESALMILE 500 PR Mesalamine DR (500mg):Uses, Side effect, Interactions, Pictuers, ETC.......

Digestive health plays a vital role in overall well-being, yet disorders of the intestine are becoming increasingly common in India due to changing food habits, stress, irregular routines, and genetic factors. Among these conditions, Inflammatory Bowel Disease (IBD)—especially Ulcerative Colitis—has emerged as a chronic and often distressing condition that significantly affects quality of life.

MESALMILE 500 PR, containing Mesalamine Delayed Release (DR) 500 mg, is a trusted anti-inflammatory medicine widely used in the treatment and maintenance of remission in ulcerative colitis and related bowel disorders. Designed to release the active drug directly in the intestine, it helps control inflammation at the source while minimising systemic side effects.

This comprehensive blog explains everything you need to know about MESALMILE 500 PR—its composition, mechanism of action, uses, benefits, dosage, safety profile, precautions, and lifestyle guidance—presented in clear, easy-to-understand language for Indian patients and caregivers.

Understanding Inflammatory Bowel Disease (IBD)

Inflammatory Bowel Disease refers to chronic inflammatory conditions of the gastrointestinal tract. The two main types are:

• Ulcerative Colitis

• Crohn’s Disease

Among these, Ulcerative Colitis (UC) is more common in India and primarily affects the large intestine (colon) and rectum.

What is Ulcerative Colitis?

Ulcerative colitis is a long-term inflammatory condition where the inner lining of the colon becomes inflamed, ulcerated, and irritated. The disease often follows a pattern of flare-ups and remission, meaning symptoms can worsen and improve over time.

Common Symptoms

• Frequent loose stools or diarrhoea

• Blood or mucus in stools

• Abdominal pain and cramping

• Urgency to pass stools

• Fatigue and weakness

• Weight loss in severe cases

If left untreated, ulcerative colitis can lead to complications such as anaemia, dehydration, colon damage, and increased cancer risk.

What is MESALMILE 500 PR?

MESALMILE 500 PR is a delayed-release oral tablet containing Mesalamine (also known as Mesalazine) 500 mg. It belongs to the 5-Aminosalicylic Acid (5-ASA) group of medicines.

This medication is specifically formulated to:

• Deliver the drug directly to the inflamed areas of the intestine

• Reduce inflammation of the colon lining

• Control symptoms and maintain remission

MESALMILE 500 PR is commonly prescribed by gastroenterologists for long-term management of ulcerative colitis.

Composition of MESALMILE 500 PR

Each delayed-release tablet contains:

• Mesalamine DR – 500 mg

• Excipients as required

The delayed-release (DR) formulation ensures that the tablet passes through the stomach intact and releases the medicine in the intestine, where it is most needed.

How MESALMILE 500 PR Works

Mesalamine is a locally acting anti-inflammatory agent.

Mechanism of Action

• Inhibits inflammatory mediators such as prostaglandins and leukotrienes

• Reduces swelling, redness, and ulceration of the intestinal lining

• Acts directly on the colon mucosa

• Helps heal damaged intestinal tissue

Unlike steroids or immunosuppressants, mesalamine works locally in the gut with minimal absorption into the bloodstream, making it safer for long-term use.

Why Delayed-Release Mesalamine Matters

The delayed-release formulation of MESALMILE 500 PR is particularly important because:

• It prevents breakdown of the drug in stomach acid

• Ensures targeted delivery to the colon

• Improves treatment effectiveness

• Reduces systemic side effects

This targeted approach makes MESALMILE 500 PR ideal for chronic inflammatory bowel conditions.

Uses of MESALMILE 500 PR

MESALMILE 500 PR is used for the treatment and prevention of inflammatory bowel diseases, including:

1. Ulcerative Colitis

• Induces remission during mild to moderate flare-ups

• Maintains remission and prevents relapses

2. Proctitis and Proctosigmoiditis

Helps reduce inflammation in the rectum and lower colon.

3. Maintenance Therapy

Used long-term to prevent recurrence of symptoms in patients with controlled disease.

Benefits of MESALMILE 500 PR

• Direct anti-inflammatory action in the colon

• Effective symptom relief in ulcerative colitis

• Helps maintain long-term remission

• Lower risk of steroid-related side effects

• Suitable for prolonged use under medical supervision

• Improves bowel function and quality of life

Dosage and Administration

Recommended Dosage

The dosage depends on:

• Severity of the disease

• Phase of treatment (active disease or maintenance)

• Patient’s response to therapy

Typically, MESALMILE 500 PR is taken multiple times daily as advised by the doctor.

How to Take

• Swallow the tablet whole with water

• Do not crush, chew, or break the tablet

• Can be taken with or without food

• Take at the same time each day for best results

Never change the dose or stop the medicine abruptly without consulting your doctor.

Duration of Treatment

Ulcerative colitis is a chronic condition. MESALMILE 500 PR may be prescribed:

• For short-term use during flare-ups

• For long-term maintenance to prevent relapse

Regular follow-up and colon monitoring may be advised by your doctor.

Who Can Take MESALMILE 500 PR?

Suitable for:

• Adults diagnosed with ulcerative colitis

• Patients requiring long-term maintenance therapy

• Individuals intolerant to steroids

Not recommended for:

• Patients allergic to salicylates

• Severe kidney impairment (unless advised by a specialist)

• Children, unless specifically prescribed

Possible Side Effects

MESALMILE 500 PR is generally well tolerated.

Common Side Effects

• Nausea

• Mild abdominal discomfort

• Headache

• Flatulence

Less Common Side Effects

• Diarrhoea

• Skin rash

• Dizziness

Rare Side Effects

• Kidney function changes

• Severe allergic reactions

• Worsening of colitis symptoms

If any unusual or severe symptoms occur, medical advice should be sought immediately.

Precautions and Warnings

• Regular kidney function tests may be recommended

• Inform your doctor about liver or kidney disease

• Avoid use if allergic to aspirin or salicylates

• Maintain adequate hydration

• Do not discontinue during remission without medical advice

Use During Pregnancy and Breastfeeding

• Use during pregnancy only if clearly needed

• Breastfeeding mothers should consult a doctor

• Always inform your healthcare provider if planning pregnancy

Drug Interactions

Inform your doctor if you are taking:

• NSAIDs

• Blood thinners

• Immunosuppressants

• Other medications affecting kidney function

Lifestyle and Dietary Tips for Ulcerative Colitis Patients

Medication works best when supported by lifestyle changes:

Dietary Guidance

• Eat small, frequent meals

• Avoid spicy, oily, and processed foods

• Reduce dairy if lactose intolerant

• Increase fluid intake

• Avoid alcohol and smoking

Lifestyle Measures

• Manage stress through yoga or meditation

• Maintain a healthy sleep routine

• Follow regular medical check-ups

Why Choose MESALMILE 500 PR?

MESALMILE 500 PR stands out because:

• Proven anti-inflammatory action

• Targeted delayed-release formulation

• Suitable for chronic management

• Better safety profile compared to steroids

• Helps patients maintain normal daily life

It is a reliable option for patients seeking long-term control of ulcerative colitis.

Conclusion

MESALMILE 500 PR, containing Mesalamine Delayed Release 500 mg, is a cornerstone therapy in the management of ulcerative colitis and inflammatory bowel disease. By acting directly on the inflamed intestinal lining, it effectively controls symptoms, promotes healing, and helps maintain remission with a favourable safety profile.

Frequently Asked Questions (FAQs)

Is MESALMILE 500 PR safe for long-term use?

Yes, it is commonly used long-term to maintain remission under medical supervision.

Does it cure ulcerative colitis?

It does not cure the disease but effectively controls inflammation and prevents relapses.

Can I stop the medicine once symptoms improve?

No. Stopping abruptly may lead to relapse. Always consult your doctor.

Does it cause weight gain?

Mesalamine is not associated with weight gain.

How long does it take to show results?

Symptom improvement is usually seen within a few weeks.

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