Tenofovir Alafenamide 25 mg Tablet – Uses, Benefits, Dosage, Side Effects & Safety.

What is Tenofovir Alafenamide?

Tenofovir alafenamide is an antiviral medication (AF) to treat chronic (long term) hepatitis B virus (HBV) infection. It is prescribed medication for the treatment of HIV-1 infection and chronic Hepatitis B virus (HBV) infection It belongs to the class of nucleotide reverse transcriptase inhibitors (NRTIs), which work by blocking the replication of viral genetic material, thereby reducing the viral load in the body.

Compared to older Tenofovir formulations, such as Tenofovir Disoproxil Fumarate (TDF), TAF offers enhanced kidney safety and improved bone health, making it a preferred option for long-term therapy.

The medication is approved for use in adults and adolescents weighing at least 35 kg, often as part of combination therapy with other antiviral drugs.  

Uses of Tenofovir Alafenamide 25 mg Tablet

Tenofovir Alafenamide is primarily used for:

1. Chronic Hepatitis B Treatment: Helps reduce the viral load and slows the progression of liver disease. Tenofovir Alafenamide works by blocking the replication of the hepatitis B virus. This action helps reduce the viral load, control liver inflammation, and prevent long-term liver damage such as cirrhosis or liver failure. By targeting the virus within liver cells, it supports overall liver health and slows disease progression.

2. HIV Management (in combination therapy): Sometimes used as part of antiretroviral therapy (ART) in adults. Tenofovir Alafenamide (TAF) is also available in fixed-dose combination pills, often paired with emtricitabine (FTC) to simplify treatment and enhance antiviral effectiveness.

3. Prevention of Liver Complications: Reduces the risk of liver cirrhosis, liver failure, and hepatocellular carcinoma in chronic HBV patients.

4. Improving Immune Function: Helps in stabilizing immune responses in HBV-infected individuals.

How Tenofovir Alafenamide Works

Tenofovir Alafenamide 25 mg Tablet is a prodrug of Tenofovir. Once ingested, it is converted into the active form tenofovir diphosphate inside infected cells. This active compound:

• Inhibits reverse transcriptase, an enzyme the virus uses to replicate its genetic material.

• Prevents the virus from multiplying, reducing the viral load in the blood.

• Helps the immune system control the infection and prevents liver damage over time.

Because TAF is active at lower doses in target cells, it offers less systemic exposure, making it safer for kidneys and bones compared to TDF.

How to Take Tenofovir Alafenamide 25 mg

• Take one tablet daily, preferably with food to improve absorption.

• Swallow the tablet whole with a glass of water; do not crush or chew it.

• Follow your doctor’s instructions regarding dosage and duration.

• Do not stop the medication on your own without consulting your healthcare provider.  

What Are the Benefits of Tenofovir Alafenamide?

Tenofovir Alafenamide (TAF) is a modern antiretroviral medication primarily used in the treatment of HIV and chronic hepatitis B infections. One of the key benefits of TAF is its ability to effectively suppress viral replication, helping patients achieve and maintain an undetectable viral load. By controlling the virus in the body, it reduces the risk of disease progression and transmission, allowing individuals to lead healthier, more active lives.  

Another significant advantage of Tenofovir Alafenamide is its improved safety profile compared to older formulations like Tenofovir Disoproxil Fumarate (TDF). TAF is administered at a lower dose and is better absorbed by the cells where it is needed, which helps minimize potential side effects on the kidneys and bones. This makes it a preferred choice for long-term therapy, especially in patients who may be at risk of renal impairment or bone density loss. 

Additionally, TAF offers convenience and adherence benefits. Its once-daily dosing regimen is simple, which improves compliance and reduces the chances of missed doses. Combined with its effectiveness and safety, these advantages make Tenofovir Alafenamide a highly reliable option for managing chronic viral infections. Overall, TAF provides a balanced approach that supports both viral suppression and patient well-being over the long term.

Side Effects of Tenofovir Alafenamide 25 mg Tablet

While generally well-tolerated, some users may experience:

• Nausea

• Headache

• Fatigue

• Abdominal pain or discomfort

• Dizziness

• Diarrhea

• Insomnia

• Weight loss

• Increased liver enzymes (rare)

• Rash or mild skin reactions

Note: Serious side effects are rare. Kidney or bone problems are less common than with older Tenofovir formulations. Report any unusual symptoms to your doctor immediately. 

Why Choose Steris Healthcare for Tenofovir Alafenamide 25 mg Tablet?  

Steris Healthcare's Tenofovir Alafenamide 25 mg tablets offer a modern, effective solution for managing chronic hepatitis B (HBV) and HIV-1 infections. This formulation is designed to suppress viral replication, thereby reducing the risk of liver damage and enhancing patient quality of life. 

A key advantage of Steris Healthcare's Tenofovir Alafenamide is its improved safety profile. Compared to older formulations, it has a reduced risk of kidney and bone toxicity, making it a preferable choice for long-term therapy. Additionally, the once-daily dosing regimen promotes better adherence and consistent viral suppression. 

Steris Healthcare is committed to quality and patient care. Their Tenofovir Alafenamide tablets are manufactured under stringent quality controls, ensuring efficacy and safety. By choosing Steris Healthcare, patients and healthcare providers can trust in a reliable partner dedicated to improving health outcomes.  

Frequently Asked Questions:  

1. What is Tenofovir Alafenamide 25 mg used for? 

Tenofovir Alafenamide 25 mg is primarily used to treat chronic hepatitis B virus (HBV) infection in adults. It helps reduce the viral load, control liver inflammation, and prevent progression to liver cirrhosis, liver failure, or liver cancer. In some cases, it is also used as part of HIV combination therapy for viral suppression. 

2. What class is Tenofovir Alafenamide?
Tenofovir Alafenamide belongs to the class of nucleotide reverse transcriptase inhibitors (NRTIs). These drugs work by blocking viral replication, preventing the virus from multiplying within the body. 

3. What is Tenofovir Alafenamide?
Tenofovir Alafenamide (TAF) is an antiviral prodrug that converts into its active form tenofovir diphosphate inside infected cells. It is a modern version of Tenofovir with improved safety for kidneys and bones while maintaining strong antiviral activity against HBV and HIV. 

4. How long should I take Tenofovir for Hepatitis B?
Tenofovir is usually taken long-term, often for several years or indefinitely. Do not stop without your doctor’s guidance to avoid viral rebound.

5. How long does Tenofovir stay in your body?
TAF is quickly absorbed, but its active form stays in cells for several days, allowing once-daily dosing. Effects decline after stopping the medication.

6. What vitamins should you avoid if you have Hepatitis B?
Avoid high doses of Vitamin A, and Vitamin B3 (niacin), and unnecessary iron supplements, as they can stress the liver. Always consult your doctor before taking any supplements.