Telmisartan (40mg), Chlorthalidone (6.25mg) .. . . . ... .

TELMISTRUM CH 6.25  
Telmisartan (40mg), Chlorthalidone (6.25mg)
Telmisartan combined with Chlorthalidone is another therapeutic approach for managing hypertension (high blood pressure), similar in concept to Telmisartan combined with Hydrochlorothiazide (HCTZ), but with a different diuretic component. This combination leverages the benefits of an angiotensin II receptor blocker (ARB) with a thiazide-like diuretic to effectively lower blood pressure through complementary mechanisms. Here's an overview of each component and the rationale for their combination:

Telmisartan
Class: Angiotensin II Receptor Blocker (ARB)
Mechanism of Action: Telmisartan blocks the action of angiotensin II, a substance that narrows blood vessels, thereby relaxing and widening the blood vessels. This results in lowered blood pressure and reduced strain on the heart.
Indications: Primarily used to treat high blood pressure, Telmisartan can also be used to reduce the risk of stroke, heart attack, and death from cardiovascular causes in patients who are at risk.
Chlorthalidone
Class: Thiazide-like Diuretic
Mechanism of Action: Chlorthalidone works by increasing the excretion of sodium and water through the kidneys, which reduces the volume of fluid in the blood vessels and decreases blood pressure. It's considered more potent and has a longer duration of action compared to traditional thiazide diuretics like HCTZ.
Indications: Used for the management of hypertension, Chlorthalidone is also effective in reducing the risk of cardiovascular events in patients with high blood pressure.
TELMISTRUM CH 6.25  

Synergistic Effect: TELMISTRUM CH 6.25 
provides a potent antihypertensive effect by targeting different aspects of blood pressure regulation. This can lead to more significant reductions in blood pressure compared to monotherapy, especially in patients whose blood pressure is not adequately controlled by a single agent.
Advantages over Telmisartan + HCTZ: Chlorthalidone has been shown in some studies to be more effective at reducing cardiovascular events compared to HCTZ. Its longer half-life can provide more sustained blood pressure control over 24 hours.
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