OXIFYLINE PR 400 Mg : MedlinePlus Drug Information.

Introduction

Pentoxifylline 400 mg is a vasodilator and hemorheologic agent used to improve blood flow in peripheral vascular diseases. The PR (Prolonged-Release) formulation like OXIFYLINE PR 400 ensures a sustained effect throughout the day with fewer dosing intervals.It works by reducing blood viscosity, improving red blood cell flexibility, and enhancing microcirculation, especially in areas affected by poor blood flow.

Pentoxifylline 400 mg Uses

OXIFYLINE PR 400 is prescribed for conditions that involve poor blood flow or vascular insufficiency, such as:

• Intermittent claudication due to peripheral arterial disease (PAD)

• Cerebral vascular insufficiency

• Diabetic peripheral neuropathy

• Chronic occlusive arterial disease

• Vascular dementia (off-label)

• Raynaud’s disease (off-label)

Tab Pentoxifylline 400 mg uses focus on improving oxygen delivery to muscles and tissues by enhancing microcirculation.

Pentoxifylline Mechanism of Action

Pentoxifylline works by:

• Inhibiting phosphodiesterase (PDE) → increases intracellular cAMP

• Improves erythrocyte flexibility → better passage through narrowed capillaries

• Reduces platelet aggregation → improves circulation

• Decreases blood viscosity → enhances peripheral oxygenation

• Mild vasodilation → increases blood flow, especially in ischemic tissues

These combined actions lead to better oxygen delivery and reduced symptoms like pain and cramps in limbs during exercise or movement.

Pentoxifylline Dose and Administration

• Recommended dose: 400 mg two or three times daily depending on clinical need

• OXIFYLINE PR 400: One tablet twice daily after meals (morning and evening)

• Maximum dose: 1200 mg/day

• Duration: Treatment is often long-term in chronic conditions

Dosage may be adjusted in patients with renal impairment or elderly patients.

How to Take OXIFYLINE PR 400

• Take orally after meals.

• Swallow the tablet whole – do not crush or chew.

• Consistent dosing improves blood flow gradually over weeks.

Pentoxifylline 400 mg Side Effects

Common Side Effects

• Nausea

• Vomiting

• Headache

• Dizziness

• Bloating or abdominal discomfort

Less Common / Serious Side Effects

• Hypotension

• Chest pain or palpitations

• Skin rashes

• Allergic reactions (rare)

• Bleeding tendencies (especially with anticoagulants)

Stop medication and seek medical help if you notice severe dizziness, irregular heartbeat, or signs of allergy.

Precautions and Warnings

• Use cautiously in:

  • Patients with bleeding disorders

  • Post-surgical or trauma cases

  • Severe coronary artery disease

  • Liver or kidney dysfunction

• Not recommended during pregnancy or lactation unless clearly needed

• Avoid alcohol while on therapy

Drug Interactions

Pentoxifylline may interact with:

• Anticoagulants (e.g., warfarin): Increased bleeding risk

• Antihypertensive drugs: May enhance blood pressure-lowering effects

• Theophylline: May increase toxicity levels

• Ciprofloxacin: May increase serum pentoxifylline levels

Storage Instructions

• Store below 30°C in a dry, dark place

• Keep out of reach of children

• Protect from moisture and heat

FAQs About Pentoxifylline 400 mg Tablet (OXIFYLINE PR 400)

1. What is Pentoxifylline 400 used for?

It is used to improve blood flow in conditions like intermittent claudication, diabetic neuropathy, and vascular insufficiency.

2. How long should I take Pentoxifylline 400 mg?

It may take 2 to 8 weeks to notice benefits. Duration is decided by your doctor based on response and condition.

3. Can I take Pentoxifylline on an empty stomach?

No, it is best taken after meals to reduce gastrointestinal discomfort.

4. Is Pentoxifylline a blood thinner?

It is not a classic blood thinner but has mild anti-platelet effects. It improves blood flow by reducing viscosity and improving RBC flexibility.

5. Can I stop Pentoxifylline suddenly?

Do not stop suddenly without consulting your doctor, especially in chronic vascular disorders.

Conclusion

OXIFYLINE PR 400, containing Pentoxifylline 400 mg, is a trusted solution for enhancing microcirculation in patients with peripheral vascular diseases. It provides relief from leg pain, cramps, and mobility limitations due to poor blood flow. With its prolonged-release action, it ensures sustained blood flow improvement while minimizing gastrointestinal side effects.Always take this medication under proper medical guidance and report any unusual symptoms promptly.

About The Company

Steris Healthcare Pvt Ltd, widely recognized as Sterispharma, was established in February 2018 by a team of seasoned experts from the pharmaceutical sector. Based in Navi Mumbai, the company is proudly certified by WHO, GMP, and ISO, underscoring its unwavering commitment to quality and patient safety. Sterispharma is driven by a mission to make affordable, premium-quality medicines accessible throughout India, adhering strictly to WHO-recommended standards. Through its user-friendly online pharmacy platforms, customers can effortlessly order medications with home delivery services.

Sterispharma boasts an extensive portfolio of healthcare solutions, ranging from treatments for rare diseases to essential everyday healthcare needs. Their comprehensive product lineup addresses multiple therapeutic areas including Cardiology, Asthma, Respiratory Disorders, Nasal Care, Diabetes, Endocrinology, Gastroenterology, Orthopedics, Anti-infective/Antibiotic Therapy, General Medicine, Urology, Neurology, Nephrology, Oncology, Gynecology, Pediatrics, Dental Care, and Dermatology. Medications are easily available for online purchase through their official websites — Sterisonline, Sterisindia, and Sterispharma — offering a seamless and reliable healthcare experience.

For further information 

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