Obeticholic acid 5 mg mono cartoon
Oct 19, 2022
OB-COLLAR 5: Obeticholic Acid (5mg) – Complete Overview
OB-COLLAR 5 is a prescription medication that contains Obeticholic Acid (5mg) as its active ingredient. Obeticholic Acid is a bile acid analog and a farnesoid X receptor (FXR) agonist, primarily used in the treatment of certain liver diseases, particularly Primary Biliary Cholangitis (PBC) and non-alcoholic steatohepatitis (NASH). This medication is designed to help manage liver dysfunction, improve liver function tests, and reduce inflammation in patients with chronic liver diseases.
What is OB-COLLAR 5?
OB-COLLAR 5 is a drug formulated with Obeticholic Acid (5mg) that helps improve liver function in conditions like PBC and NASH. It works by modulating the farnesoid X receptor (FXR), a receptor that plays a key role in regulating bile acid synthesis, transport, and liver function. Through activation of FXR, Obeticholic Acid helps to control liver damage and reduce inflammation, making it an effective treatment option for liver-related conditions.
Key Features and Ingredients
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Active Ingredient: Obeticholic Acid (5mg) is the key active compound in OB-COLLAR 5, which works by stimulating the farnesoid X receptor (FXR), a nuclear receptor found in the liver and intestine that regulates the balance of bile acids and metabolic pathways related to liver function.
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Mechanism of Action: By activating FXR, Obeticholic Acid reduces bile acid synthesis and enhances the transport of bile acids in the liver, leading to an improvement in liver function. It also helps reduce liver inflammation and fibrosis, which are common in chronic liver diseases.
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Formulation: OB-COLLAR 5 typically comes in a tablet form, where each tablet contains 5mg of Obeticholic Acid, and the recommended dosage is determined by the healthcare provider.
Uses of OB-COLLAR 5
OB-COLLAR 5 is primarily prescribed for the following liver-related conditions:
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Primary Biliary Cholangitis (PBC):
- PBC is an autoimmune liver disease that leads to the gradual destruction of bile ducts in the liver, resulting in bile buildup, liver inflammation, fibrosis, and potential cirrhosis. Obeticholic Acid helps reduce bile acid buildup, alleviate inflammation, and slow the progression of the disease.
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Non-Alcoholic Steatohepatitis (NASH):
- NASH is a more advanced form of non-alcoholic fatty liver disease (NAFLD), where fat builds up in the liver, causing inflammation, liver cell damage, and fibrosis. Obeticholic Acid helps improve liver function by reducing inflammation, liver damage, and fibrosis associated with NASH.
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Liver Fibrosis and Cirrhosis:
- In patients with liver fibrosis or cirrhosis, Obeticholic Acid can help slow disease progression by reducing inflammation and liver fibrosis, thus improving overall liver health.
How Does OB-COLLAR 5 Work?
Obeticholic Acid works by activating the farnesoid X receptor (FXR) in the liver, which regulates the synthesis and transport of bile acids. FXR activation leads to:
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Decreased Bile Acid Synthesis: By decreasing the synthesis of bile acids in the liver, Obeticholic Acid helps reduce the buildup of toxic bile acids, which can cause liver damage in diseases like PBC and NASH.
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Improved Bile Acid Transport: It helps enhance the transport of bile acids in the liver, reducing bile acid accumulation and thus decreasing liver inflammation and fibrosis.
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Reduced Inflammation and Fibrosis: The activation of FXR by Obeticholic Acid helps reduce the inflammatory response in the liver and prevents further damage to liver cells, reducing the risk of fibrosis and cirrhosis.
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Improved Liver Function: By improving bile acid regulation, Obeticholic Acid helps maintain normal liver function, which can reduce the symptoms associated with chronic liver diseases.
Benefits of OB-COLLAR 5
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Improvement in Liver Function:
- OB-COLLAR 5 helps regulate bile acid production, reducing the toxic effects of excess bile acids in the liver. This leads to improved liver function and a decrease in liver-related symptoms, such as fatigue and jaundice.
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Reduction in Liver Inflammation:
- Obeticholic Acid is known to reduce inflammation in the liver, which is a key factor in the progression of diseases like PBC and NASH. By reducing liver inflammation, it helps slow disease progression.
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Prevention of Liver Fibrosis:
- OB-COLLAR 5 helps reduce liver fibrosis (scarring), a common complication in chronic liver diseases. This can prevent the progression to cirrhosis and improve long-term liver health.
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Slowing Down Disease Progression:
- By regulating bile acid levels and reducing inflammation, Obeticholic Acid slows the progression of PBC and NASH, which can lead to liver failure if untreated.
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Well-Tolerated in Patients:
- Clinical studies have shown that Obeticholic Acid is generally well-tolerated, with manageable side effects. This makes it a viable treatment option for individuals with chronic liver conditions.
How to Use OB-COLLAR 5
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Dosage: The typical dose of OB-COLLAR 5 is 5mg once daily, but the exact dosage and frequency should be determined by your healthcare provider based on your condition and response to treatment.
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Administration: OB-COLLAR 5 should be taken orally, usually with or without food. Take the tablet as prescribed, and do not crush or chew it. Swallow the tablet whole with a glass of water.
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Monitor Liver Function: Since Obeticholic Acid affects liver function, it is important to monitor liver enzymes and other liver-related parameters regularly during treatment to ensure optimal therapeutic response and safety.
Possible Side Effects of OB-COLLAR 5
While OB-COLLAR 5 is generally well tolerated, some people may experience side effects, including:
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Fatigue: A common side effect that can occur during treatment with Obeticholic Acid.
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Abdominal Discomfort or Pain: Some individuals may experience discomfort, bloating, or pain in the abdominal region.
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Itching (Pruritus): Itching is a known side effect, particularly in patients with liver diseases like PBC. This may be related to the reduction in bile acid buildup.
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Elevated Liver Enzymes: In some cases, Obeticholic Acid can cause a temporary increase in liver enzymes, which requires close monitoring by a healthcare provider.
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Headache: Some individuals may experience mild headaches during treatment.
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Diarrhea: In rare cases, patients may experience gastrointestinal issues such as diarrhea.
If you experience any severe side effects, such as severe abdominal pain, yellowing of the skin or eyes, or unexplained weight loss, contact your healthcare provider immediately.
Precautions and Warnings
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Pregnancy and Breastfeeding: The safety of Obeticholic Acid during pregnancy and breastfeeding is not well established. It should only be used during pregnancy if the benefits outweigh the risks. Consult your doctor before using OB-COLLAR 5 if you are pregnant or breastfeeding.
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Liver Impairment: OB-COLLAR 5 is contraindicated in patients with decompensated cirrhosis (severe liver impairment) or advanced liver disease. It should be used with caution in patients with moderate liver impairment.
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Kidney Impairment: There is no specific warning for kidney impairment, but it’s always important to discuss any kidney-related concerns with your healthcare provider.
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Drug Interactions: OB-COLLAR 5 may interact with other medications, particularly those that affect liver enzymes. Inform your doctor about any other medications or supplements you are taking.
FAQ Section
Q1: What conditions does OB-COLLAR 5 treat?
OB-COLLAR 5 is primarily used to treat Primary Biliary Cholangitis (PBC) and Non-Alcoholic Steatohepatitis (NASH), two chronic liver diseases that involve inflammation and damage to the liver.
Q2: How long does it take for OB-COLLAR 5 to work?
The response time to Obeticholic Acid can vary. Patients may start experiencing improvements in liver function tests and reduction in symptoms within several weeks of starting treatment, but it can take longer for some individuals.
Q3: Can OB-COLLAR 5 be used for other liver diseases?
While OB-COLLAR 5 is primarily used for PBC and NASH, it may be prescribed off-label for other liver conditions under a doctor’s supervision.
Q4: Is OB-COLLAR 5 safe for long-term use?
Yes, OB-COLLAR 5 can be used long-term for chronic liver diseases, but regular monitoring of liver function is essential to ensure safety and effectiveness during treatment.
Q5: Can I stop taking OB-COLLAR 5 if I feel better?
It’s important to continue taking OB-COLLAR 5 as prescribed by your doctor, even if you feel better, to manage your liver disease. Consult your doctor before discontinuing or altering your medication.
Conclusion
OB-COLLAR 5 (Obeticholic Acid 5mg) is an effective medication for managing chronic liver diseases such as Primary Biliary Cholangitis (PBC) and Non-Alcoholic Steatohepatitis (NASH). By targeting the farnesoid X receptor (FXR), it helps regulate bile acid synthesis, reduce liver inflammation, and improve overall liver function. Regular monitoring and doctor consultations are necessary to ensure optimal use and to avoid potential side effects.
About The Author
Steris Healthcare Pvt Ltd, known as Sterispharma, was founded in February 2018 by a team of experienced professionals in the pharmaceutical industry. Headquartered in Navi Mumbai, the company holds certifications from WHO, GMP, and ISO, reflecting its dedication to maintaining high standards of quality and safety. Sterispharma’s mission is to provide affordable, high-quality medications across India, strictly adhering to WHO guidelines. With the convenience of an online pharmacy, customers can easily order medicines with home delivery options.
For further information
Email: info@sterispharma.com / contact@sterispharma.com
Call/WhatsApp: 8209542042 , 8824175417
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