Nicoumalone (1mg) & NICOMALOM 1 Tablet - Steris Healthcare PVT LTD………

Introduction

Nicoumalone, also known as acenocoumarol, is a vitamin K antagonist and oral anticoagulant used to prevent and treat blood clots. It is structurally and functionally similar to warfarin and is widely prescribed in India for long-term anticoagulation therapy.

Nicoumalone 1 mg Tablet Uses

NICOMALOM 1 is used to:

• Prevent deep vein thrombosis (DVT)

• Prevent pulmonary embolism (PE)

• Manage atrial fibrillation with a risk of embolism

• Prevent systemic thromboembolism in patients with prosthetic heart valves

• Treat and prevent recurrent thrombotic events

Nicoumalone tablets are essential for patients at high risk of clot-related complications, especially post-surgery or in chronic heart conditions.

Nicoumalone Mechanism of Action

Nicoumalone acts by:

• Inhibiting vitamin K epoxide reductase, an enzyme needed for synthesizing clotting factors II, VII, IX, and X.

• This leads to the reduction of active clotting proteins, impairing blood coagulation.

It does not dissolve existing clots but prevents new clots from forming or existing ones from growing.

Nicoumalone Dosage and Administration

• Initial dose: Usually 2–4 mg daily, adjusted based on INR (International Normalized Ratio) values.

• Maintenance dose: Typically ranges between 1–8 mg per day.

• NICOMALOM 1 mg may be used alone or in combination to titrate precise dosage.

Dosage is individualized based on INR monitoring. Never self-adjust the dose.

Monitoring and INR Target

• INR must be regularly monitored.

  • Target INR:

    • 2.0–3.0 for most conditions

    • 2.5–3.5 for mechanical heart valves

Nicoumalone Side Effects

Common Side Effects:

• Bleeding gums

• Easy bruising

• Nosebleeds

• Hematuria (blood in urine)

• Gastrointestinal discomfort

Serious Side Effects (Seek medical attention):

• Hemorrhage (internal or external)

• Blood in stools or vomit

• Severe headache or dizziness

• Rash, fever, or liver enzyme elevations (rare)

Precautions and Warnings

• Contraindicated in:

  • Active bleeding

  • Pregnancy (teratogenic)

  • Severe liver or kidney disease

  • Recent major surgery

• Caution in:

  • Elderly patients

  • Patients with uncontrolled hypertension

• Avoid major dietary changes in vitamin K-rich foods (e.g., spinach, broccoli).

Drug Interactions

Nicoumalone interacts with many drugs, including:

• Antibiotics (increase INR)

• NSAIDs (increase bleeding risk)

• Antifungals

• Thyroid hormones

• Phenytoin, carbamazepine (may lower INR)

 Always inform your doctor about all the medications and supplements you take.

Storage Instructions

• Store in a cool, dry place below 25°C

• Protect from moisture and direct sunlight

• Keep out of reach of children

FAQs About Nicoumalone 1 mg (NICOMALOM 1)

1. What is NICOMALOM 1 used for?

NICOMALOM 1 is used to prevent and treat blood clots in conditions like DVT, PE, atrial fibrillation, and mechanical heart valves.

2. How is the dose of Nicoumalone determined?

The dose is determined based on INR blood tests, which reflect how thin your blood is. It is adjusted frequently to maintain the therapeutic range.

3. Can I take NICOMALOM with food?

Yes, it can be taken with or without food. However, consistency in diet is key, especially with foods rich in vitamin K.

4. What should I avoid while taking Nicoumalone?

Avoid NSAIDs, alcohol, and sudden dietary changes. Also, consult your doctor before starting any new medication.

5. Is Nicoumalone safe during pregnancy?

No. Nicoumalone is teratogenic and should not be used during pregnancy. It may cause fetal bleeding and birth defects.

Conclusion

NICOMALOM 1 (Nicoumalone 1 mg tablet) is a trusted, cost-effective oral anticoagulant widely used in managing clotting disorders. With regular INR monitoring and proper dosage, it ensures safe and effective long-term prevention of thromboembolic events. Always follow your doctor’s guidance closely to avoid complications.

About The Company

Steris Healthcare Pvt Ltd, widely recognized as Sterispharma, was established in February 2018 by a team of seasoned experts from the pharmaceutical sector. Based in Navi Mumbai, the company is proudly certified by WHO, GMP, and ISO, underscoring its unwavering commitment to quality and patient safety. Sterispharma is driven by a mission to make affordable, premium-quality medicines accessible throughout India, adhering strictly to WHO-recommended standards. Through its user-friendly online pharmacy platforms, customers can effortlessly order medications with home delivery services.

Sterispharma boasts an extensive portfolio of healthcare solutions, ranging from treatments for rare diseases to essential everyday healthcare needs. Their comprehensive product lineup addresses multiple therapeutic areas including Cardiology, Asthma, Respiratory Disorders, Nasal Care, Diabetes, Endocrinology, Gastroenterology, Orthopedics, Anti-infective/Antibiotic Therapy, General Medicine, Urology, Neurology, Nephrology, Oncology, Gynecology, Pediatrics, Dental Care, and Dermatology. Medications are easily available for online purchase through their official websites — Sterisonline, Sterisindia, and Sterispharma — offering a seamless and reliable healthcare experience.

For further information 

Email: info@sterispharma.com / contact@sterispharma.com

Call/WhatsApp: 8209542042 , 8824175417

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