Managing Type 2 Diabetes with Gliclazide (40mg) and Metformin (500mg)

Introduction

GLICLAGLAZE M 40 is an oral antidiabetic medication containing a combination of Gliclazide (40mg) and Metformin (500mg). It is widely used in the management of Type 2 Diabetes Mellitus (T2DM) to control blood sugar levels and prevent complications associated with diabetes.

Gliclazide belongs to the sulfonylurea class of medications, which stimulates insulin secretion, while Metformin is a biguanide that enhances insulin sensitivity and reduces glucose production in the liver. Together, they provide effective glycemic control, reducing the risk of diabetic complications such as neuropathy, nephropathy, and cardiovascular diseases.

Key Ingredients

1. Gliclazide (40mg)

Gliclazide is a second-generation sulfonylurea that promotes the release of insulin from pancreatic beta cells. It works by binding to sulfonylurea receptors on these cells, leading to increased insulin secretion. Additionally, Gliclazide has antioxidant properties that help protect blood vessels from diabetes-related damage.

2. Metformin (500mg)

Metformin is a first-line medication for Type 2 Diabetes. It primarily works by:

• Reducing hepatic glucose production (gluconeogenesis).

• Enhancing peripheral insulin sensitivity, allowing muscles to use glucose effectively.

• Decreasing intestinal glucose absorption, reducing postprandial (after meal) blood sugar spikes.

• Aiding in weight management, which is beneficial for overweight diabetic patients.

How GLICLAGLAZE M 40 Works?

The combination of Gliclazide and Metformin offers a dual-action mechanism for diabetes control:

• Gliclazide stimulates the pancreas to release more insulin, helping reduce blood sugar levels.

• Metformin decreases the amount of glucose produced by the liver and increases insulin sensitivity in body tissues.

This combination is effective for individuals whose diabetes is not adequately controlled with diet, exercise, or monotherapy with either drug alone.

Uses of GLICLAGLAZE M 40

GLICLAGLAZE M 40 is primarily used for:

• Managing Type 2 Diabetes Mellitus (T2DM)

• Improving insulin sensitivity and reducing insulin resistance

• Lowering fasting and postprandial blood sugar levels

• Reducing the risk of diabetes-related complications

• Helping with weight management in obese diabetic patients

Dosage and Administration

Recommended Dosage:

• Usual dose: One tablet twice daily (morning and evening) or as directed by a doctor.

• Maximum dose: Should not exceed the prescribed limit as per medical advice.

How to Take It?

• Take GLICLAGLAZE M 40 with meals to reduce the risk of stomach upset.

• Swallow the tablet whole with water; do not crush or chew.

• Maintain a consistent schedule for better blood sugar control.

Missed Dose:

• If a dose is missed, take it as soon as remembered.

• If it's close to the next dose, skip the missed dose and continue with the regular schedule.

• Do not double the dose to make up for a missed one.

Overdose:

• Overdosing can cause hypoglycemia (low blood sugar), leading to symptoms like sweating, dizziness, shakiness, confusion, and fainting.

• In case of severe hypoglycemia, seek immediate medical attention.

Side Effects of GLICLAGLAZE M 40

Like any medication, GLICLAGLAZE M 40 may cause side effects, though not everyone experiences them.

Common Side Effects:

• Hypoglycemia (low blood sugar) – dizziness, sweating, hunger, confusion

• Nausea and vomiting

• Diarrhea or stomach discomfort

• Metallic taste in the mouth

• Mild weight loss

Serious Side Effects (Seek Immediate Medical Help):

• Severe hypoglycemia (confusion, fainting, seizures)

• Lactic acidosis (associated with Metformin) – symptoms include muscle pain, breathing difficulty, extreme fatigue

• Severe allergic reactions – swelling of the face, rash, difficulty breathing

• Liver or kidney dysfunction – yellowing of skin/eyes (jaundice), dark urine

Precautions and Warnings

Who Should Not Take GLICLAGLAZE M 40?

• Individuals with Type 1 Diabetes (insulin-dependent diabetes)

• Patients with severe kidney or liver disease

• Those allergic to Gliclazide, Metformin, or sulfonylureas

• People with diabetic ketoacidosis (DKA)

• Pregnant or breastfeeding women (unless prescribed by a doctor)

Special Precautions:

• Monitor blood sugar levels regularly to avoid hypoglycemia or hyperglycemia.

• If undergoing surgery or any major medical treatment, consult a doctor before continuing this medication.

• Limit alcohol consumption as it can increase the risk of lactic acidosis with Metformin.

• Maintain a balanced diet and regular exercise routine for optimal diabetes management.

Drug Interactions

Certain medications may interact with GLICLAGLAZE M 40, affecting its efficacy or increasing side effects.

Medications That May Interact:

• Other antidiabetic drugs (e.g., insulin, gliptins) – may cause excessive hypoglycemia.

• Beta-blockers (e.g., propranolol, atenolol) – can mask hypoglycemia symptoms.

• Corticosteroids (e.g., prednisone) – may increase blood sugar levels.

• Diuretics (e.g., thiazides, furosemide) – can reduce Metformin effectiveness.

• Alcohol – increases the risk of lactic acidosis.

What to Do?

• Always inform your doctor about any other medications or supplements you are taking.

• Avoid self-medication without consulting a healthcare provider.

Lifestyle Tips for Better Diabetes Management

Dietary Recommendations:

• Opt for high-fiber foods (whole grains, vegetables, legumes).

• Limit refined sugars and carbohydrates.

• Consume lean proteins (chicken, fish, tofu) for stable energy levels.

• Stay hydrated with water and avoid sugary beverages.

Exercise Guidelines:

• Engage in at least 30 minutes of moderate exercise daily (walking, cycling, swimming).

• Strength training helps improve insulin sensitivity.

• Avoid exercising on an empty stomach to prevent hypoglycemia.

Monitoring Blood Sugar:

• Check fasting and postprandial glucose levels regularly.

• Keep a record of diet, medication intake, and sugar levels for better management.

Conclusion

GLICLAGLAZE M 40, containing Gliclazide (40mg) and Metformin (500mg), is an effective combination therapy for Type 2 Diabetes Mellitus. It enhances insulin secretion, reduces glucose production, and improves insulin sensitivity, helping to maintain stable blood sugar levels.

For best results, follow a prescribed dosage, maintain a healthy diet and exercise routine, and monitor blood sugar levels regularly. Always consult a healthcare professional before starting or modifying any diabetes treatment plan.

About The Author

STERIS HEALTHCARE PVT LTD

Steris Healthcare Pvt Ltd, known as Sterispharma, was founded in February 2018 by a team of experienced professionals in the pharmaceutical industry. Headquartered in Navi Mumbai, the company holds certifications from WHO, GMP, and ISO, reflecting its dedication to maintaining high standards of quality and safety. Sterispharma’s mission is to provide affordable, high-quality medications across India, strictly adhering to WHO guidelines. With the convenience of an online pharmacy, customers can easily order medicines with home delivery options.

For further information 

Email: info@sterispharma.com / contact@sterispharma.com

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