Isosorbide Mononitrate 20 mg Tablet: Uses, Dosage, Side Effects & Benefits – CARDULES ISMN 20

Introduction

CARDULES ISMN 20 contains Isosorbide Mononitrate 20 mg, a long-acting nitrate used primarily to prevent angina pectoris (chest pain) in patients with coronary artery disease. It works by relaxing and dilating blood vessels, thereby improving blood flow to the heart and reducing its oxygen demand.Unlike nitroglycerin or isosorbide dinitrate, Isosorbide Mononitrate is not used for acute angina attacks, but for long-term prevention.

Isosorbide Mononitrate 20 mg Uses

CARDULES ISMN 20 is used in the treatment of:

• Chronic Stable Angina: Reduces frequency and severity of chest pain episodes.

• Variant Angina (Prinzmetal’s): Offers vascular relaxation in spastic coronary vessels (under specialist guidance).

• Coronary Artery Disease: Improves oxygen supply-demand balance in the myocardium.

• Heart Failure (Adjunctive Use): Sometimes prescribed with other medications to reduce cardiac workload.

• Post-MI Cardiac Recovery: Used to stabilize blood flow and prevent recurrent ischemic episodes.

How CARDULES ISMN 20 Works

Isosorbide Mononitrate releases nitric oxide (NO), which activates guanylate cyclase and increases cyclic GMP levels. This results in:

• Vasodilation of veins and arteries

• Reduced preload and afterload

• Decreased myocardial oxygen consumption

• Enhanced coronary perfusion

Being long-acting, it maintains a steady nitrate level in the blood and provides 24-hour angina prevention when dosed appropriately.

Dosage & Administration

• Typical Adult Dose: One tablet (20 mg) once or twice daily, or as directed by the physician.

• Administration: Take orally, preferably in the morning and early afternoon (to avoid tolerance).

• Important: Maintain a nitrate-free interval of 10–12 hours in a 24-hour period to prevent tolerance.

Side Effects of Isosorbide Mononitrate 20 mg

Common Side Effects:

• Headache (initial and common side effect)

• Lightheadedness or dizziness

• Flushing

• Nausea

• Fatigue

• Low blood pressure

Rare but Serious:

• Severe hypotension

• Fainting (syncope)

• Increased heart rate (reflex tachycardia)

• Worsening angina if tolerance develops

Precautions and Warnings

• Do not use for acute angina attacks—not a rescue medication.

• Avoid in severe hypotension, hypovolemia, or acute myocardial infarction without stability.

• Use with caution in:

  • Patients with severe anemia

  • Individuals with increased intracranial pressure

  • Pregnant or breastfeeding women (use only if prescribed)

• Do not stop medication suddenly; taper off gradually under medical supervision.

Drug Interactions

Avoid co-administration with:

• PDE5 inhibitors (e.g., Sildenafil, Tadalafil, Vardenafil) – can cause life-threatening hypotension

• Alcohol – may enhance blood pressure-lowering effects

• Other antihypertensives – monitor BP closely

Frequently Asked Questions (FAQs)

Q1. What is the use of Isosorbide Mononitrate 20 mg?
A1. It is used to prevent chest pain (angina) by improving blood flow and reducing strain on the heart.

Q2. Can I use CARDULES ISMN 20 for sudden chest pain?
A2. No. It is meant for preventive use only. Use a fast-acting nitrate (like nitroglycerin) for acute attacks.

Q3. What time of day should I take CARDULES ISMN 20?
A3. Preferably in the morning and, if a second dose is prescribed, in the early afternoon, to maintain a nitrate-free interval overnight.

Q4. Is it safe to take CARDULES ISMN 20 with Sildenafil (Viagra)?
A4. No. The combination can lead to a dangerous drop in blood pressure.

Q5. What should I do if I forget a dose?
A5. Take it as soon as you remember, but skip it if it's close to your next dose. Do not double up.

Conclusion

CARDULES ISMN 20 (Isosorbide Mononitrate 20 mg) is a trusted medication for the long-term prevention of angina in patients with cardiovascular diseases. Its once- or twice-daily regimen, when managed with proper intervals, offers consistent protection against chest pain episodes and improves heart function. Always use under a physician's supervision for safe and effective results.

About The Author

STERIS HEALTHCARE PVT LTD

Steris Healthcare Pvt Ltd, known as Sterispharma, was founded in February 2018 by a team of experienced professionals in the pharmaceutical industry. Headquartered in Navi Mumbai, the company holds certifications from WHO, GMP, and ISO, reflecting its dedication to maintaining high standards of quality and safety. Sterispharma’s mission is to provide affordable, high-quality medications across India, strictly adhering to WHO guidelines. With the convenience of an online pharmacy, customers can easily order medicines with home delivery options.

For further information 

Email: info@sterispharma.com / contact@sterispharma.com

Call/WhatsApp: 8209542042 , 8824175417

BUY NOW