Isosorbide Mononitrate 10 mg Tablet: Uses, Dosage, Side Effects & Precautions

Introduction

CARDULES ISMN 10 is a prescription medication that contains Isosorbide Mononitrate 10 mg, a long-acting nitrate used to prevent angina pectoris (chest pain) associated with coronary artery disease. It works by relaxing the smooth muscles in blood vessels, improving oxygen delivery to the heart and reducing cardiac workload. It is not used for acute angina attacks but for long-term prevention of anginal episodes.

Isosorbide Mononitrate Uses (CARDULES ISMN 10)

CARDULES ISMN 10 is commonly prescribed for the management and prevention of cardiovascular conditions such as:

1. Chronic Stable Angina

Used for the long-term prevention of chest pain by improving blood flow and reducing oxygen demand on the heart.

2. Variant (Prinzmetal’s) Angina

Helps manage coronary artery spasm that causes episodic chest pain, especially at rest.

3. Ischemic Heart Disease

Improves myocardial oxygenation, thus preventing angina episodes due to narrowed coronary arteries.

4. Heart Failure (Adjunct Use)

Sometimes used in combination with other heart failure medications to reduce preload and afterload, easing the workload of the heart.

Note: CARDULES ISMN 10 is not suitable for immediate relief during an angina attack. It is a preventive therapy.

How CARDULES ISMN 10 Works

Isosorbide Mononitrate acts as a prodrug for nitric oxide (NO), which activates guanylate cyclase in vascular smooth muscle. This cascade results in increased cyclic GMP levels, leading to:

• Venodilation: Reduces preload (volume of blood returning to the heart)

• Arterial dilation: Lowers afterload (resistance the heart pumps against)

• Coronary artery dilation: Increases blood flow to the heart muscle

• Reduced myocardial oxygen demand: Eases chest pain and enhances exercise tolerance

Dosage and Administration

• Timing: Doses are usually spaced 7 hours apart (e.g., morning and early afternoon) to maintain a nitrate-free interval and prevent tolerance.

• Route: Oral, with or without food.

• Do not crush or chew the tablet unless specified.

Always follow your healthcare provider’s instructions for the correct dosage and frequency.

Isosorbide Mononitrate Side Effects (CARDULES ISMN 10)

Common Side Effects:

• Headache (most common)

• Dizziness or lightheadedness

• Flushing

• Fatigue

• Nausea

Less Common but Serious Side Effects:

• Severe hypotension (low blood pressure)

• Fainting or syncope

• Reflex tachycardia (fast heartbeat)

• Worsening of angina on abrupt withdrawal

If you experience severe dizziness, chest pain, or fainting, seek immediate medical help.

Precautions and Warnings

• Tolerance Development: Continuous exposure may reduce effectiveness. Always maintain a nitrate-free interval of 10–12 hours daily.

• Avoid Abrupt Discontinuation: Gradual tapering is advised under medical supervision.

• Do Not Use With: PDE5 inhibitors (e.g., Sildenafil, Tadalafil) due to the risk of life-threatening hypotension.

• Caution In:

  • Hypovolemia

  • Severe anemia

  • Glaucoma

  • Recent stroke or traumatic brain injury

• Pregnancy Category C: Use only if clearly needed under medical advice.

Drug Interactions

Avoid combining with:

• Phosphodiesterase inhibitors: Sildenafil (Viagra), Tadalafil (Cialis), Vardenafil

• Alcohol: Increases risk of hypotension and dizziness

• Antihypertensive drugs: Monitor for excessive BP lowering

• Other Nitrates or Nitrites: Risk of cumulative vasodilation

FAQs about CARDULES ISMN 10 (Isosorbide Mononitrate 10 mg)

Q1. What is CARDULES ISMN 10 used for?

A: It is used to prevent angina pectoris by dilating blood vessels and enhancing oxygen delivery to the heart.

Q2. Can I take this medication daily?

A: Yes, but it must include a nitrate-free interval of at least 10–12 hours to prevent tolerance.

Q3. What happens if I miss a dose?

A: Take it as soon as you remember. If it’s close to your next dose, skip the missed one. Do not double dose.

Q4. Can I take CARDULES ISMN 10 with alcohol?

A: No. Alcohol can intensify dizziness and the blood pressure-lowering effects of the medicine.

Q5. Is it safe in pregnancy?

A: Use only if prescribed by a physician. It falls under Pregnancy Category C.

Conclusion

CARDULES ISMN 10 (Isosorbide Mononitrate 10 mg) is a trusted long-term treatment for preventing angina and improving cardiac function in coronary artery disease. Its mechanism targets both arterial and venous dilation, easing the workload on the heart and improving patient quality of life. Like all nitrates, proper dosing, spacing, and medical guidance are key to maximizing benefits and minimizing risks.

About The Author

STERIS HEALTHCARE PVT LTD

Steris Healthcare Pvt Ltd, known as Sterispharma, was founded in February 2018 by a team of experienced professionals in the pharmaceutical industry. Headquartered in Navi Mumbai, the company holds certifications from WHO, GMP, and ISO, reflecting its dedication to maintaining high standards of quality and safety. Sterispharma’s mission is to provide affordable, high-quality medications across India, strictly adhering to WHO guidelines. With the convenience of an online pharmacy, customers can easily order medicines with home delivery options.

For further information 

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