Cinacalcet 30 mg Tabs

Introduction

CINASELECT 30 is a Cinacalcet (30mg) tablet that belongs to the class of calcimimetics. It is primarily used for managing secondary hyperparathyroidism in patients with chronic kidney disease (CKD) undergoing dialysis. Additionally, it is prescribed for treating parathyroid carcinoma and severe hypercalcemia in patients with primary hyperparathyroidism who cannot undergo parathyroid surgery. By effectively lowering parathyroid hormone (PTH) levels, CINASELECT 30 plays a crucial role in maintaining calcium-phosphorus balance and preventing complications such as bone disorders and cardiovascular risks.

Key Ingredients

• Cinacalcet Hydrochloride (30mg) – A calcimimetic agent that modulates calcium-sensing receptors in the parathyroid gland, reducing PTH secretion and regulating calcium levels in the blood.

• Excipients – Include lactose monohydrate, povidone, croscarmellose sodium, magnesium stearate, and other inactive ingredients that support tablet formulation and stability.

Uses of CINASELECT 30

CINASELECT 30 is primarily used for the treatment of:

1. Secondary Hyperparathyroidism (SHPT) – Common in patients with CKD on dialysis, leading to excessive PTH production, bone weakness, and cardiovascular complications.

2. Parathyroid Carcinoma – A rare endocrine malignancy associated with severe hypercalcemia.

3. Primary Hyperparathyroidism (PHPT) – In cases where surgery is not a viable option, CINASELECT 30 helps control high calcium levels.

How Does CINASELECT 30 Work?

Cinacalcet acts as a calcimimetic agent by increasing the sensitivity of calcium-sensing receptors (CaSR) in the parathyroid gland. This leads to a decrease in PTH secretion, subsequently reducing serum calcium and phosphate levels. The modulation of PTH levels plays a significant role in minimizing complications such as bone mineral disorders, vascular calcification, and cardiovascular disease.

Dosage and Administration

• Initial Dose: The usual starting dose of CINASELECT 30 is 30 mg once daily with food.

• Titration: The dosage is gradually increased every 2 to 4 weeks, based on PTH, calcium, and phosphate levels. The typical maintenance dose ranges from 30 mg to 180 mg per day.

• Administration: Tablets should be taken whole with food to enhance absorption and minimize gastrointestinal side effects.

• Missed Dose: If a dose is missed, it should be taken as soon as remembered unless it is close to the next scheduled dose.

Side Effects of CINASELECT 30

While CINASELECT 30 is generally well-tolerated, some patients may experience side effects, including:

Common Side Effects:

• Nausea and Vomiting – Most frequently reported, especially during initial therapy.

• Dizziness – Can occur due to a decrease in calcium levels.

• Diarrhea – Mild gastrointestinal discomfort.

• Muscle Cramps – Related to calcium level alterations.

• Fatigue – Due to metabolic changes caused by reduced PTH levels.

Serious Side Effects (Rare but Severe):

• Hypocalcemia (Low Calcium Levels):

  • Tingling sensations in fingers and lips

  • Muscle spasms or twitching

  • Seizures in extreme cases

• QT Prolongation:

  • Can lead to irregular heart rhythms

  • More common in patients with existing cardiac conditions

• Gastrointestinal Bleeding:

  • Uncommon but may occur in patients with a history of ulcers

Precautions and Warnings

Before using CINASELECT 30, it is essential to consider the following precautions:

• Hypocalcemia Risk: Monitor serum calcium levels regularly to prevent hypocalcemic complications.

• Seizure History: Patients with a history of seizures should use CINASELECT 30 with caution, as severe hypocalcemia can increase seizure risk.

• Cardiovascular Conditions: Individuals with QT prolongation or existing heart diseases should undergo ECG monitoring while on this medication.

• Gastrointestinal Disorders: Patients with a history of peptic ulcers or GI bleeding should use this medication with caution.

• Liver Impairment: Dose adjustments may be required for patients with liver dysfunction.

• Pregnancy & Breastfeeding: Use only if prescribed by a healthcare provider, as safety data in pregnant or lactating women is limited.

Drug Interactions

CINASELECT 30 may interact with several medications, including:

• Ketoconazole, Itraconazole, Fluconazole: Increase Cinacalcet levels, requiring dose adjustments.

• Rifampin & Phenytoin: Reduce Cinacalcet levels, potentially decreasing effectiveness.

• Calcium Supplements & Vitamin D: May be necessary to counteract hypocalcemia but should be monitored carefully.

• Beta-Blockers & Antiarrhythmic Drugs: CINASELECT 30 can affect heart rhythm, requiring ECG monitoring.

Price and Availability in India

The Cinacalcet 30mg price varies based on the brand, pharmacy, and location. On average, it costs ₹800 to ₹1,500 per strip of 10 tablets. It is available at major online and offline pharmacies across India.

Storage Instructions

• Store at room temperature (20°C to 25°C).

• Keep away from moisture, heat, and direct sunlight.

• Store in the original blister pack to maintain tablet stability.

• Keep out of reach of children and pets.

Frequently Asked Questions (FAQs)

1. How long does it take for CINASELECT 30 to show results?
It usually takes several weeks to see a significant reduction in PTH levels. Regular monitoring is necessary to assess effectiveness.

2. Can I stop taking CINASELECT 30 if my symptoms improve?
No. CINASELECT 30 should be taken continuously as per your doctor's instructions, as stopping it abruptly may cause rebound hyperparathyroidism.

3. Is CINASELECT 30 safe for long-term use?
Yes, but regular monitoring of calcium, phosphate, and PTH levels is required to avoid complications.

4. Can CINASELECT 30 be used in children?
It is generally not recommended for pediatric use unless prescribed by a specialist.

5. What should I do if I experience severe side effects?
Seek immediate medical attention if you experience serious side effects like seizures, severe muscle spasms, or irregular heartbeats.

Conclusion

CINASELECT 30 (Cinacalcet 30mg) is a highly effective medication for managing secondary hyperparathyroidism, parathyroid carcinoma, and primary hyperparathyroidism in cases where surgery is not an option. By regulating PTH secretion and maintaining calcium balance, it helps prevent severe complications such as bone mineral disorders and cardiovascular issues. However, regular monitoring, adherence to dosage, and awareness of potential side effects are essential to maximize its benefits.

If you are prescribed CINASELECT 30, follow your doctor’s advice, undergo periodic lab tests, and report any unusual symptoms immediately. This medication plays a crucial role in improving the quality of life for patients dealing with parathyroid disorders.

About The Author

STERIS HEALTHCARE PVT LTD

Steris Healthcare Pvt Ltd, known as Sterispharma, was founded in February 2018 by a team of experienced professionals in the pharmaceutical industry. Headquartered in Navi Mumbai, the company holds certifications from WHO, GMP, and ISO, reflecting its dedication to maintaining high standards of quality and safety. Sterispharma’s mission is to provide affordable, high-quality medications across India, strictly adhering to WHO guidelines. With the convenience of an online pharmacy, customers can easily order medicines with home delivery options.

For further information 

Email: info@sterispharma.com / contact@sterispharma.com

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