Amisulpride CR 400 mg Tablet: View Uses, Benefits, Side Effects, and More.

AMIPULSIDE CR 400 is a high-quality antipsychotic medication formulated with Amisulpride 400 mg in a controlled-release (CR) tablet. Developed to offer extended therapeutic action, this medication belongs to the atypical antipsychotic class and is primarily prescribed for the treatment of schizophrenia—a chronic and often disabling mental health condition.

With its targeted action on dopamine D2 and D3 receptors, AMIPULSIDE CR 400 helps manage both the positive and negative symptoms of schizophrenia, such as hallucinations, delusions, emotional flatness, and social withdrawal. The CR formulation ensures consistent drug levels throughout the day, enhancing compliance and symptom control.

Let’s explore the full potential of AMIPULSIDE CR 400, including its uses, benefits, dosage, side effects, precautions, and more.

What is AMIPULSIDE CR 400?

AMIPULSIDE CR 400 is a prescription antipsychotic tablet containing Amisulpride 400 mg in a controlled-release format. Amisulpride works by selectively inhibiting dopamine receptors, particularly D2 and D3 subtypes in the brain. These receptors are believed to be overactive in schizophrenia, leading to symptoms like hallucinations and delusions.

Unlike older antipsychotics, Amisulpride offers a balanced approach, effectively treating both the positive symptoms (like aggression, delusions, and hallucinations) and negative symptoms (such as apathy, anhedonia, and emotional withdrawal) of schizophrenia.

AMIPULSIDE CR 400 is ideal for long-term use as it provides steady drug levels, minimizing dosage fluctuations and improving patient outcomes.

Uses of AMIPULSIDE CR 400

The primary use of AMIPULSIDE CR 400 is the treatment of schizophrenia, especially in cases where consistent, controlled medication delivery is critical. It can be used as both an acute and maintenance therapy for individuals at various stages of the illness.

Key Indications:

Management of acute schizophrenia episodes

Long-term treatment of chronic schizophrenia

Improvement in positive symptoms (hallucinations, paranoia, delusions)

Relief from negative symptoms (lack of motivation, poor emotional expression, withdrawal)

Preventing relapse and stabilizing mood

Amisulpride’s dual mechanism of action makes it a valuable medication for patients who require continuous antipsychotic support.

How Does AMIPULSIDE CR 400 Work?

Amisulpride, the active ingredient in AMIPULSIDE CR 400, exerts its antipsychotic effects by blocking dopamine D2 and D3 receptors in the mesolimbic pathway of the brain—regions associated with mood, motivation, and psychotic symptoms.

By regulating dopamine transmission:

It reduces overactivity that leads to hallucinations and delusions

It enhances dopamine activity in underactive areas, improving motivation and social behavior

The controlled-release formulation ensures prolonged drug release, providing 24-hour symptom coverage, reducing the risk of relapse, and improving adherence.

Benefits of AMIPULSIDE CR 400

When used appropriately and under medical supervision, AMIPULSIDE CR 400 offers several clinical advantages:

Comprehensive Symptom Relief

It addresses both positive and negative symptoms of schizophrenia, something many older antipsychotics fail to achieve.

Improved Medication Compliance

The once-daily controlled-release tablet simplifies dosing schedules, encouraging better patient adherence.

Fewer Extrapyramidal Side Effects

Compared to typical antipsychotics, Amisulpride shows a lower incidence of movement disorders, especially at lower doses.

Fast Onset of Action

Many patients report early symptom improvement, sometimes within the first 1–2 weeks of treatment.

Better Social Functioning

By managing negative symptoms, AMIPULSIDE CR 400 can improve social interaction, motivation, and quality of life.

Side Effects of AMIPULSIDE CR 400

While AMIPULSIDE CR 400 (Amisulpride 400 mg) is effective, some individuals may experience side effects. These are typically dose-dependent and can range from mild to serious.

Common Side Effects:

Drowsiness or insomnia

Weight gain

Increased prolactin levels (may cause menstrual changes, breast tenderness)

Anxiety or agitation

Tremors, restlessness, or muscle rigidity (extrapyramidal symptoms)

Less Common But Serious Side Effects:

Abnormal heart rhythms (QT prolongation)

Seizures

Neuroleptic Malignant Syndrome (NMS) – rare but potentially life-threatening

Liver enzyme elevation

Increased blood sugar levels (hyperglycemia)

Important: If any of these symptoms persist or worsen, it is essential to consult a healthcare provider immediately.

Precautions Before Using AMIPULSIDE CR 400

Before starting treatment with AMIPULSIDE CR 400, your healthcare provider will evaluate your overall health status. The following factors should be discussed:

Pre-existing heart conditions (especially arrhythmias)

Liver or kidney disorders

History of seizures or epilepsy

Diabetes or metabolic syndrome

History of breast cancer or hormone-sensitive tumors

Electrolyte imbalances (low potassium or magnesium)

Alcohol or substance abuse

Pregnancy or breastfeeding status

Elderly patients, particularly those with dementia-related psychosis, should use this medication cautiously due to a higher risk of stroke and mortality.

Drug Interactions: What to Avoid with AMIPULSIDE CR 400

Amisulpride may interact with several other medications, affecting its efficacy or increasing the risk of side effects.

Dosage and Administration of AMIPULSIDE CR 400

AMIPULSIDE CR 400 is available as a controlled-release tablet, typically taken once daily, with or without food. Dosage will depend on the severity of symptoms, patient response, and doctor's recommendation.
 

Typical Dosage Guidelines:

Acute schizophrenia: Start with a lower dose (e.g., 200–400 mg), adjusted based on response

Maintenance therapy: Often 400 mg once daily or as directed

Maximum dose: Should not exceed the prescribed limit without medical supervision