Calcium Polystyrene Sulphonate Powder: Mechanism of Action and Side Effects.

Introduction

Polystern Sachet contains Calcium Polystyrene Sulphonate Powder, a widely used medication for managing hyperkalemia (high potassium levels). This ion-exchange resin plays a vital role in maintaining electrolyte balance in patients suffering from chronic kidney disease (CKD), acute renal failure, Addison’s disease, or medication-induced potassium retention.Hyperkalemia is a potentially life-threatening condition that can cause cardiac arrhythmias, muscle paralysis, and even sudden cardiac arrest. Calcium Polystyrene Sulphonate removes excess potassium from the body by exchanging calcium ions for potassium ions in the intestines, preventing severe complications.

Key Ingredient: Calcium Polystyrene Sulphonate

The active ingredient in Polystern Sachet is Calcium Polystyrene Sulphonate, a cation-exchange resin from the sulfonated polystyrene group. It has a strong affinity for potassium and is highly effective in lowering potassium levels in the blood.

Key Properties:

• Cation-exchange resin that replaces potassium with calcium in the gastrointestinal tract

• Works primarily in the large intestine

• Gradually reduces potassium levels over several hours

• Can be administered orally or rectally (enema) for severe cases

• Commonly used for chronic kidney disease (CKD), dialysis patients, and hyperkalemia caused by medications

Uses of Polystern Sachet

Polystern Sachet is prescribed primarily for managing hyperkalemia in various medical conditions, including:

1. Chronic Kidney Disease (CKD)

Patients with CKD have reduced potassium excretion, leading to dangerously high potassium levels. Calcium Polystyrene Sulphonate gradually removes potassium, preventing further complications.

2. Acute Kidney Injury (AKI)

In cases of sudden kidney failure, potassium excretion is compromised. This medication helps prevent severe hyperkalemia-related complications.

3. Hyperkalemia Due to Medications

Certain drugs, such as ACE inhibitors, potassium-sparing diuretics, NSAIDs, and beta-blockers, increase potassium levels. Polystern Sachet counteracts this potassium buildup.

4. Addison’s Disease

In Addison’s disease, the adrenal glands fail to produce enough hormones, causing excess potassium retention. Polystern Sachet helps regulate potassium levels in such cases.

5. Heart Conditions & Arrhythmias

High potassium levels can trigger dangerous arrhythmias and cardiac issues. This powder is used as a preventive measure for heart patients.

6. Post-Dialysis Potassium Management

Patients on dialysis may experience potassium fluctuations. Polystern Sachet helps maintain safe potassium levels between dialysis sessions.

7. Liver Cirrhosis with Hyperkalemia

Liver disease can lead to electrolyte imbalances, including hyperkalemia. This medication helps regulate potassium levels in such conditions.

Dosage & Administration

The dosage of Polystern Sachet depends on hyperkalemia severity, kidney function, and the patient’s overall health condition. It should always be taken under medical supervision.

Recommended Dosage:

• Adults: 15 g (one sachet) 1 to 4 times daily

• Children: 0.5 g per kg of body weight 1 to 4 times daily

• Neonates (Newborns): 0.5 g per kg divided into multiple doses

How to Use:

• The powder should be mixed with water or soft food like yogurt or honey before consumption.

• Take this medicine 1-3 hours before or after meals for maximum effectiveness.

• For severe cases, it can be administered rectally (enema) under medical supervision.

Key Benefits of Polystern Sachet

1. Effective Potassium Reduction

• Helps maintain safe potassium levels in patients with kidney disease.

• Prevents life-threatening cardiac arrhythmias due to hyperkalemia.

2. Non-Sodium Formula

• Unlike Sodium Polystyrene Sulfonate, which can increase sodium levels and worsen hypertension, Calcium Polystyrene Sulphonate does not contribute to sodium overload.

3. Easy to Use & Convenient

• Available in sachet form, making it easy to mix and consume.

• Can be administered orally or rectally.

4. Helps Avoid Emergency Dialysis

• Provides an alternative to dialysis in mild to moderate hyperkalemia cases.

Side Effects of Polystern Sachet

While Polystern Sachet is generally safe, some patients may experience side effects.

Common Side Effects:

• Constipation

• Loss of appetite

• Mild nausea

• Abdominal discomfort

Rare but Serious Side Effects:

• Severe hypokalemia (too low potassium levels)

• Electrolyte imbalances (especially with prolonged use)

• Intestinal obstruction or necrosis (very rare but serious)

• Hypercalcemia (high calcium levels in the blood)

Warning: If you experience irregular heartbeat, muscle weakness, or confusion, seek immediate medical attention.

Precautions & Warnings

Who Should Avoid Polystern Sachet?

• Patients with hypokalemia (low potassium levels)

• Individuals with severe constipation or bowel obstruction

• People with hypercalcemia or conditions like hyperparathyroidism

• Patients on calcium supplements (may lead to excessive calcium levels)

Drug Interactions

Polystern Sachet may interact with:

• Digoxin (heart medication)

• Antacids & laxatives (can affect resin absorption)

• Lithium & thyroid medications

• Calcium supplements (risk of hypercalcemia)

Always inform your doctor about any other medications before using this sachet.

Conclusion

Polystern Sachet, containing Calcium Polystyrene Sulphonate Powder, is a vital medication for hyperkalemia management, especially in patients with kidney disease and heart conditions. Its non-sodium formula makes it safer for individuals prone to hypertension and fluid retention.While effective, it should always be used under medical supervision to avoid complications like electrolyte imbalances and severe constipation. Regular monitoring of potassium, calcium, and sodium levels is recommended during treatment.If you or a loved one has been prescribed Polystern Sachet, ensure proper dosage adherence and dietary modifications to maximize its benefits and prevent potential side effects. Always consult a doctor before making any changes to your treatment plan.

About The Author

STERIS HEALTHCARE PVT LTD

Steris Healthcare Pvt Ltd, known as Sterispharma, was founded in February 2018 by a team of experienced professionals in the pharmaceutical industry. Headquartered in Navi Mumbai, the company holds certifications from WHO, GMP, and ISO, reflecting its dedication to maintaining high standards of quality and safety. Sterispharma’s mission is to provide affordable, high-quality medications across India, strictly adhering to WHO guidelines. With the convenience of an online pharmacy, customers can easily order medicines with home delivery options.

For further information 

Email: info@sterispharma.com / contact@sterispharma.com

Call/WhatsApp: 8209542042 , 8824175417

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