SILODOSIA M 50

Silodosia M 50 is a fixed-dose combination tablet with two active ingredients that work on different parts of the same problem.

Silodosin 8 mg relaxes the muscle at the prostate and bladder neck by blocking alpha-1A receptors. This eases the voiding problems of BPH: weak stream, hesitancy, straining and incomplete emptying.

Mirabegron 50 mg ER is a beta-3 receptor agonist. It relaxes the bladder wall muscle (detrusor) during the storage phase, so the bladder holds more urine comfortably. This eases the storage problems: urgency, frequent urination, night-time urination and urge incontinence.

Many men with an enlarged prostate have both voiding and storage symptoms at the same time. Treating the outlet alone sometimes leaves the urgency and frequency behind. A combination tablet lets one daily dose address both, in line with the treatment plan your urologist decides.

Product at a glance: Silodosia M 50 is a tablet containing mirabegron 50 mg ER and silodosin 8 mg for men with BPH and overactive bladder symptoms, taken once daily after food as prescribed. It is marketed by Steris Healthcare Pvt. Ltd. (Jaipur, India), WHO-GMP and ISO certified, in packs of 10 tablets.

Product Information

Why Is Silodosia M 50 Important?

Urinary symptoms in ageing men are easy to dismiss as "normal", but they can quietly reduce quality of life:

• Broken sleep from getting up several times at night
• Urgency and leakage that make travel, work meetings, temple visits and social events stressful
• Reduced confidence and withdrawal from daily activities
• Incomplete emptying, which can raise the risk of urinary infections and bladder stones

When both an enlarged prostate and an overactive bladder are involved, a single-ingredient therapy may relieve only part of the problem. A well-chosen combination can mean fewer tablets, a simpler routine and better adherence. A simple regimen matters because BPH and OAB are long-term conditions, and treatment works only when taken regularly.

Why this matters for Indian patients and clinics: India has a large and growing population of men over 50. Urologists and physicians increasingly see mixed LUTS (lower urinary tract symptoms), and pharmacies and hospitals need dependable, GMP-manufactured combination options.

Key Benefits 

• Targets both voiding and storage symptoms: works on the weak stream and the urgency together.
• Reduces urgency and urge leakage: the mirabegron component helps the bladder store urine.
• Eases straining and incomplete emptying: the silodosin component relaxes the prostate-bladder outlet.
• May cut down night-time trips to the bathroom: supports more restful sleep.
• One tablet, once daily: convenient and helps adherence.
• No anticholinergic dry-mouth profile from the bladder component: mirabegron works through a different pathway from anticholinergic bladder medicines, so dry mouth and constipation are generally less of a concern, though they can still occur.
• Made under WHO-GMP and ISO standards: assured manufacturing quality from Steris Healthcare.

Precautions Before Taking 

Tell your doctor before starting if you:

• Have high blood pressure. Mirabegron can raise blood pressure, and it should not be used in severe uncontrolled hypertension. Check your blood pressure regularly.
• Take blood pressure medicines. Silodosin can lower blood pressure on standing, so your doctor should review your full regimen.
• Have difficulty passing urine or significant bladder outlet obstruction. Mirabegron can cause urinary retention in such patients.
• Have kidney or liver disease. Dose limits apply and this fixed-dose tablet may not be suitable.
• Have any heart rhythm problem or a history of palpitations.
• Plan cataract or glaucoma surgery. Silodosin is linked with Intraoperative Floppy Iris Syndrome (IFIS). Inform the eye surgeon.
• Have not been screened for prostate cancer. BPH and prostate cancer can cause similar symptoms and need to be ruled out.
• Are allergic to mirabegron, silodosin or any ingredient.

Possible Side Effects

Common:

• Retrograde ejaculation (little or no semen), harmless and reversible
• Dizziness
• Headache
• Raised blood pressure
• Nasal congestion, sore throat or common-cold-like symptoms
• Urinary tract infection
• Nausea, constipation or diarrhea
• Faster heartbeat (palpitations)

Less common:

• Low blood pressure on standing
• Dry mouth
• Tiredness or drowsiness
• Reduced libido or erectile difficulty
• Skin rash or itching

Frequently Asked Questions

1. Where can I buy mirabegron and silodosin online?
Mirabegron and silodosin combination medicines can be purchased online through licensed pharmacies in India, subject to prescription requirements. Check the product strength, manufacturer, pack size, expiry date, and authenticity before purchasing.

2. What is the price of mirabegron and silodosin?
The price depends on the specific strengths, brand, manufacturer, pack size, pharmacy, and applicable offers or taxes. For the current price, contact the pharmacy or Steris Healthcare directly.

3. Can I order mirabegron and silodosin online?
Yes, a mirabegron and silodosin combination may be ordered online through a licensed pharmacy when a valid prescription is provided where required. The pharmacy may verify the prescription before processing the order.

4. Is mirabegron and silodosin available from Steris Healthcare?
Availability depends on current stock and distribution. To confirm whether a mirabegron and silodosin product is currently available from Steris Healthcare, contact the company directly with the required strength and pack-size details.

5. What is mirabegron and silodosin used for?
The combination of mirabegron and silodosin may be prescribed for urinary symptoms associated with benign prostatic hyperplasia (BPH), particularly when symptoms such as frequent urination, urgency, or difficulty with urination occur. Silodosin helps relax the muscles around the prostate and bladder outlet, while mirabegron helps relax the bladder muscle and can reduce urinary urgency and frequency.

6. What is the composition of mirabegron and silodosin?
The composition contains mirabegron and silodosin as active pharmaceutical ingredients. The exact strength of each ingredient depends on the particular product formulation and should be checked on the product packaging or prescription.

7. Is a prescription required for mirabegron and silodosin?
Yes. Mirabegron and silodosin combination medicines should be used under the supervision of a qualified healthcare professional. A prescription may be required when purchasing the medicine from a licensed pharmacy.

8. How should mirabegron and silodosin be taken?
Take the medicine exactly as prescribed by your doctor. The dosage and timing depend on the specific strengths in the combination and your medical condition. Do not crush, split, or change the dosage unless your healthcare professional specifically instructs you to do so.

9. What should I know before buying mirabegron and silodosin?
Before purchasing, verify the exact strengths, manufacturer, pack size, expiry date, and prescription requirements. Inform your doctor about any other medicines you take and any existing medical conditions, particularly blood-pressure or urinary problems. Silodosin may cause dizziness or a drop in blood pressure, while mirabegron can affect blood pressure in some patients.

10. How can I order mirabegron and silodosin online?
To order the medicine online, select a licensed pharmacy, provide a valid prescription when requested, verify the product name, strengths, pack size, and manufacturer, and complete the pharmacy's ordering and payment process. For information about availability and ordering from Steris Healthcare, contact the company directly.