SILDOSIA M 50

Urinary problems such as frequent urination, urgency, weak urine flow, and difficulty in bladder emptying are increasingly common among adult and elderly men. These symptoms often arise due to conditions like Benign Prostatic Hyperplasia (BPH) and Overactive Bladder (OAB), which significantly affect quality of life if left untreated. Modern medical management focuses on relieving symptoms, improving bladder control, and restoring patient comfort without compromising safety.

SILDOSIA M 50 Tablets is an advanced combination therapy containing Mirabegron 50 mg (Extended Release) and Silodosin 8 mg, formulated to provide comprehensive relief from lower urinary tract symptoms (LUTS). This dual-action medicine is designed to target both bladder overactivity and prostate-related urinary obstruction, making it a preferred choice for physicians managing complex urinary disorders.

Manufactured with stringent quality standards by Steris Healthcare Pvt. Ltd., SILDOSIA M 50 offers effective symptom control, better urinary flow, and long-lasting comfort for patients dealing with chronic urinary conditions.

Composition

Each tablet of SILDOSIA M 50 contains:

• Mirabegron 50 mg (Extended Release)

• Silodosin 8 mg

This carefully balanced formulation ensures sustained therapeutic action with improved patient compliance.

How SILDOSIA M 50 Works (Mechanism of Action)

Mirabegron 50 mg ER

Mirabegron is a β3-adrenergic receptor agonist. It works by relaxing the detrusor muscle of the bladder during the storage phase of the urinary cycle. This relaxation increases bladder capacity and reduces involuntary bladder contractions, thereby decreasing urgency, frequency, and urge incontinence.

The extended-release formulation ensures steady drug levels throughout the day, minimizing fluctuations and improving tolerability.

Silodosin 8 mg

Silodosin is a highly selective alpha-1A adrenergic receptor blocker. It relaxes the smooth muscles of the prostate and bladder neck, allowing urine to flow more easily. This action significantly reduces symptoms like:

• Difficulty in starting urination

• Weak urine stream

• Incomplete bladder emptying

• Straining during urination

Together, these two medicines provide dual relief—improving bladder storage and urine flow simultaneously.

Uses of SILDOSIA M 50 Tablets

SILDOSIA M 50 is commonly prescribed for the management of:

• Benign Prostatic Hyperplasia (BPH)

• Overactive Bladder (OAB)

• Lower Urinary Tract Symptoms (LUTS) in men

• Frequent urination (day and night)

• Urinary urgency and urge incontinence

• Weak urine stream

• Difficulty in bladder emptying

This combination therapy is especially useful for patients who experience both storage and voiding symptoms.

Benefits of SILDOSIA M 50

Comprehensive Symptom Control

By addressing both bladder overactivity and prostate obstruction, SILDOSIA M 50 provides broader symptom relief compared to monotherapy.

Improved Urinary Flow

Silodosin helps reduce resistance at the bladder outlet, improving urine flow and reducing discomfort.

Reduced Urinary Frequency & Urgency

Mirabegron significantly decreases sudden urges to urinate and frequent bathroom visits.

Better Quality of Life

Patients experience uninterrupted sleep, improved confidence, and enhanced daily comfort.

Once-Daily Dosing

The extended-release formulation allows convenient once-daily administration, improving adherence.

Well-Tolerated Profile

Compared to older therapies, this combination offers effective results with a lower risk of bothersome side effects.

Dosage and Administration

• The usual recommended dose is one tablet once daily, preferably at the same time each day.

• The tablet should be swallowed whole with water.

• Do not crush, chew, or break the tablet.

• Can be taken with or without food, as advised by the physician.

Dosage adjustments may be required in elderly patients or those with kidney or liver impairment. Always follow your doctor’s instructions.

Side Effects of SILDOSIA M 50

Like all medicines, SILDOSIA M 50 may cause side effects, although not everyone experiences them.

Common Side Effects

• Dizziness

• Headache

• Dry mouth

• Constipation

• Nasal congestion

• Mild increase in blood pressure

Less Common Side Effects

• Retrograde ejaculation

• Fatigue

• Palpitations

• Nausea

Rare but Serious Side Effects

• Severe allergic reactions

• Significant rise in blood pressure

• Urinary retention

Patients should seek medical attention if any unusual or persistent symptoms occur.

Warnings and Precautions

Before starting SILDOSIA M 50, inform your doctor if you have:

• Severe kidney or liver disease

• Uncontrolled hypertension

• History of urinary retention

• Cardiovascular disorders

• Known hypersensitivity to Mirabegron or Silodosin

Special Precautions

• Blood pressure should be monitored regularly.

• Use with caution in elderly patients.

• Not recommended for women and children.

• Avoid driving or operating heavy machinery if dizziness occurs.

Drug Interactions

SILDOSIA M 50 may interact with:

• Strong CYP3A4 inhibitors

• Antihypertensive medicines

• Other alpha-blockers

• Certain antifungal or antibiotic medicines

Always inform your healthcare provider about all medications and supplements you are taking.

Storage Instructions

• Store in a cool, dry place below 25°C.

• Protect from moisture and direct sunlight.

• Keep out of reach of children.

Why Choose SILDOSIA M 50 from Steris Healthcare Pvt. Ltd.?

• Manufactured under strict quality control standards

• Scientifically balanced combination therapy

• Trusted by healthcare professionals across India

• Designed for long-term urinary symptom management

• Patient-centric formulation with proven efficacy

Steris Healthcare Pvt. Ltd. is committed to delivering reliable, safe, and innovative pharmaceutical solutions that enhance patient outcomes.

Conclusion

SILDOSIA M 50 Tablets, containing Mirabegron 50 mg ER and Silodosin 8 mg, represent a modern, effective solution for men suffering from bothersome urinary symptoms associated with BPH and overactive bladder. With its dual mechanism of action, once-daily convenience, and patient-friendly safety profile, it significantly improves urinary control and overall quality of life.

Frequently Asked Questions 

Is SILDOSIA M 50 suitable for long-term use?

Yes, when taken under medical supervision, it is suitable for long-term management of urinary symptoms.

How long does it take to show results?

Most patients experience improvement within a few weeks, although full benefits may take longer.

Can SILDOSIA M 50 cure BPH?

It helps manage symptoms effectively but does not permanently cure prostate enlargement.