Gliclazide SR (60mg) and Metformin SR (500mg), marketed as GLICLAGLAZE MET, is a combination medication used to manage type 2 diabetes. This dual therapy leverages the benefits of both drugs to achieve better blood glucose control, particularly in patients inadequately managed on monotherapy.

How Does It Work?

• Gliclazide SR:

  • Sulfonylurea Action: Stimulates the pancreas to release more insulin.
  • Extended Release: Provides a sustained release for consistent blood sugar control throughout the day.

• Metformin SR:

  • Biguanide Action: Decreases hepatic glucose production and improves insulin sensitivity.
  • Sustained Release: Ensures gradual absorption, reducing gastrointestinal side effects.

Uses of GLICLAGLAZE MET

• Type 2 Diabetes Management: Primarily used to improve glycemic control in type 2 diabetes patients.
• Combination Therapy: Effective for patients who do not achieve adequate control with either medication alone.

What is GLICLAGLAZE MET?

• Dose and Formulation: Combines 60mg of Gliclazide SR and 500mg of Metformin SR in a single tablet.
• Administration: Typically taken once or twice daily with meals to enhance efficacy and minimize side effects.

Side Effects

• Common Side Effects:

  • Hypoglycemia, particularly when skipping meals or engaging in intense physical activity.
  • Gastrointestinal issues such as nausea, vomiting, and diarrhea.

• Rare Side Effects:

  • Lactic acidosis, a rare but serious side effect associated with Metformin.
  • Allergic reactions including rash, itching, and swelling.

Safety Information

• Contraindications: Not suitable for patients with severe renal impairment, liver disease, or heart failure.
• Precautions: Regular monitoring of blood sugar levels, renal function, and liver enzymes is recommended. Adjust dosage based on medical advice to avoid hypoglycemia and other complications.

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