CIDINITAB CT

CIDINITAB CT is used to treat essential hypertension in adults. Hypertension is a chronic condition. It usually causes no symptoms, yet over the years it quietly damages the heart, brain, kidneys and eyes. In India, hypertension is among the most common long-term conditions seen in routine clinical practice. A large share of patients need two or more medicines to reach their target blood pressure.

This tablet combines two medicines that lower blood pressure by different routes. Cilnidipine relaxes and widens the blood vessels. Chlorthalidone helps the body remove excess salt and water through urine, which reduces the volume of fluid in the circulation. Because they act through complementary mechanisms, the combination often lowers blood pressure more effectively than either drug alone. It also lets the patient take one tablet instead of two, which makes it easier to follow the treatment daily.

Doctors usually consider this combination when blood pressure remains above target on monotherapy, or when a patient is likely to need both a vasodilator and a diuretic from the start. The decision to start, switch or stop belongs to your doctor, who will weigh your BP readings, kidney function, blood sugar, electrolytes and other medicines.

How the two ingredients work

• Cilnidipine (10 mg): a dihydropyridine calcium channel blocker that blocks L-type calcium channels in vascular smooth muscle, so arteries relax and peripheral resistance falls. It also blocks N-type calcium channels on sympathetic nerve endings. This reduces the release of norepinephrine, so there is generally less reflex increase in heart rate than with some other drugs of its class.
• Chlorthalidone (12.5 mg): a thiazide-like diuretic that acts on the distal convoluted tubule of the kidney and reduces sodium and chloride reabsorption. It has a long duration of action, so a single daily dose can give round-the-clock effect.

Product Information

Why Is CIDINITAB CT Important?

Uncontrolled high blood pressure is one of the leading modifiable risk factors for stroke, heart attack, heart failure, kidney disease and vision loss. The aim of treatment is not simply to make a number look better on a reading. It is to keep blood pressure in the target range every day, for years, so that organ damage is prevented.

Many people find this difficult for three reasons:

1. One medicine is often not enough. Clinical experience and treatment guidelines recognise that a significant proportion of hypertensive patients need combination therapy to reach target.
2. Pill burden affects adherence. The more tablets a person has to remember, the greater the chance of missed doses. A fixed-dose combination reduces this burden.
3. Hypertension is silent. Because patients often feel well, they may stop medicines on their own. Regular, uninterrupted therapy is what protects the heart, brain and kidneys.

CIDINITAB CT addresses these problems with a once-daily, two-in-one approach built around two well-understood drug classes. Cilnidipine’s dual channel action has been associated with a lower tendency to cause ankle swelling than some other calcium channel blockers. Chlorthalidone’s long half-life supports steady BP control, including the early-morning hours when cardiovascular risk is highest.

A tablet alone is not the whole answer. Reducing salt intake, staying physically active, keeping a healthy weight, limiting alcohol, quitting tobacco and managing stress all add to the effect of medication. Home BP monitoring and regular follow-up visits help your doctor adjust treatment safely.

Key Benefits 

• Dual-mechanism blood pressure control: vasodilation from cilnidipine plus fluid and salt reduction from chlorthalidone act together for a stronger BP-lowering effect than either component alone.
• Convenient once-daily dosing: one tablet replaces two separate medicines, which supports consistent use.
• Long-acting, 24-hour coverage: chlorthalidone’s long duration of action and cilnidipine’s sustained effect help maintain control between doses.
• Sympathetic nervous system modulation: cilnidipine’s N-type channel blockade may help limit reflex tachycardia (a rise in heart rate that can follow vasodilation).
• Better tolerability profile on swelling: cilnidipine is generally associated with less pedal (ankle) edema than some other dihydropyridines, and the diuretic component may further help with fluid balance.
• May support organ protection: sustained BP control lowers long-term strain on the heart, brain and kidneys. Cilnidipine has also been studied for effects on the kidneys and for lowering protein loss in urine in certain patients.
• Lower pill burden and cost of therapy: a single combination tablet can be simpler and more economical than buying two separate brands.
• Quality-assured manufacture: produced by Steris Healthcare Pvt. Ltd., a WHO-GMP and ISO-certified pharmaceutical manufacturer based in Jaipur, Rajasthan.

Precautions Before and While Taking 

• Take it only on prescription. Do not start, stop or change the dose on your own. Stopping abruptly can cause BP to rise again.
• Tell your doctor about your full medical history, especially kidney disease, liver disease, gout, diabetes, heart failure, low blood pressure, aortic stenosis, or any history of allergy to sulfonamide-type medicines.
• Pregnancy and breastfeeding: inform your doctor if you are pregnant, planning pregnancy or breastfeeding. Diuretics and antihypertensives need careful risk-benefit assessment, and this medicine should be used only if your doctor considers it clearly necessary.
• Do not use if you are allergic to cilnidipine, chlorthalidone, other thiazide or sulfonamide-derived medicines, or any ingredient of the tablet.
• Avoid in severe kidney impairment or anuria (no urine output), as chlorthalidone may be ineffective or harmful in these conditions.
• Monitor electrolytes and kidney function. Your doctor may advise periodic blood tests for sodium, potassium, calcium, uric acid, creatinine and blood sugar, particularly in older adults and those on long-term therapy.
• Watch for dehydration. Vomiting, diarrhoea, heavy sweating or poor fluid intake can increase the risk of low blood pressure and electrolyte imbalance. Contact your doctor if this happens.
• Diabetes: chlorthalidone may slightly raise blood glucose. People with diabetes should monitor sugar levels and report any change.
• Gout: thiazide-like diuretics can raise uric acid and may trigger gout attacks in susceptible people.
• Drug interactions: tell your doctor about all medicines and supplements you take, particularly:
  • other blood pressure medicines (additive BP lowering)
  • lithium (levels may rise to toxic range)
  • NSAIDs such as diclofenac or ibuprofen (can reduce the effect and affect the kidneys)
  • digoxin (low potassium can increase digoxin toxicity)
  • antidiabetic drugs and insulin (dose adjustment may be needed)
  • CYP3A4 inhibitors or inducers such as ketoconazole, erythromycin, rifampicin, carbamazepine or cimetidine (can change cilnidipine levels)
• Grapefruit juice: avoid large quantities, as it can increase blood levels of cilnidipine.
• Alcohol: may enhance the BP-lowering effect and cause dizziness. Limit or avoid it.
• Driving and machinery: dizziness can occur, especially at the start of treatment or after a dose change. Avoid driving or operating machinery until you know how the tablet affects you.
• Rise slowly from a sitting or lying position to reduce the chance of lightheadedness.
• Surgery: inform your surgeon or anaesthetist that you take this medicine before any procedure.
• Missed dose: take it as soon as you remember, unless it is nearly time for the next dose. Never double up.
• Storage: keep below 25 °C in a cool, dry place, away from light and out of the reach of children. [PLACEHOLDER: confirm storage statement from approved label.]

Possible Side Effects 

Not everyone experiences side effects, and most are mild and settle as the body adjusts. Tell your doctor if any of these persist or bother you.

Common side effects

• Headache
• Dizziness or lightheadedness
• Flushing or a feeling of warmth
• Palpitations or a feeling of rapid heartbeat
• Tiredness or weakness
• Increased urination, especially in the first days
• Nausea or mild stomach upset
• Muscle cramps (may reflect low potassium or sodium)
• Mild ankle or foot swelling

Less common side effects

• Low blood pressure, especially on standing
• Low potassium (hypokalaemia), low sodium (hyponatraemia) or low magnesium
• Raised uric acid, which may trigger gout
• Raised blood sugar or cholesterol levels
• Dry mouth and thirst
• Skin rash, itching or sensitivity to sunlight
• Constipation or diarrhoea
• Gum swelling (gingival hyperplasia), reported with calcium channel blockers

Frequently Asked Questions 

1. What is the price of cilnidipine and chlorthalidone tablets in India?

The price of cilnidipine and chlorthalidone tablets in India depends on the brand, strength, pack size, and manufacturer. Check the product packaging or contact the supplier for the latest price and availability.

2. Where can I buy cilnidipine chlorthalidone tablets?

Cilnidipine chlorthalidone tablets may be available through licensed pharmacies and authorized pharmaceutical suppliers in India. Verify the product composition, manufacturer, and prescription requirements before purchasing.

3. Which tablet contains cilnidipine and chlorthalidone?

Several branded formulations may contain cilnidipine and chlorthalidone in combination. Check the product label to confirm that both ingredients and their respective strengths match the prescribed medicine.

4. What is cilnidipine chlorthalidone tablet used for?

Cilnidipine and chlorthalidone tablets are used to manage high blood pressure (hypertension). Cilnidipine helps relax blood vessels, while chlorthalidone is a diuretic that helps the body remove excess salt and water. Use this combination only under medical supervision.

5. What is the composition of cilnidipine chlorthalidone tablets?

The composition consists of cilnidipine and chlorthalidone. A formulation may contain cilnidipine 10 mg and chlorthalidone 12.5 mg, but strengths can vary by brand. Always confirm the exact composition on the product label.

6. Is cilnidipine with chlorthalidone available in India?

Cilnidipine and chlorthalidone combination formulations may be available in India through pharmaceutical manufacturers and licensed pharmacies. Availability depends on the brand, dosage strength, and location.

7. How much does cilnidipine 10 mg with chlorthalidone 12.5 mg cost?

The price of cilnidipine 10 mg with chlorthalidone 12.5 mg varies by brand, pack size, and manufacturer. Contact a licensed pharmacy or the relevant supplier to confirm the current MRP and selling price.

8. Which manufacturer makes cilnidipine chlorthalidone tablets?

Different pharmaceutical companies may manufacture or market cilnidipine chlorthalidone tablets in India. Check the packaging for the manufacturer's name, marketer details, and applicable quality information before purchasing.

9. How can I order cilnidipine chlorthalidone tablets from a pharmaceutical supplier?

To order cilnidipine chlorthalidone tablets, contact a licensed pharmaceutical supplier, confirm the required strength and pack size, request a quotation, and verify the supplier's credentials. Follow applicable prescription and pharmaceutical purchasing regulations.

10. Do I need a prescription to buy cilnidipine chlorthalidone tablets?

Yes, these blood-pressure medicines should be used under a doctor's supervision and may be subject to prescription requirements. Consult a qualified healthcare professional before starting, stopping, or changing the dose.