Teneligliptin 20mg, Pioglitazone 15mg & Extended Release Metformin Hydrochloride 500mg ..

Introduction

TENELIGOLD PM 500 stands out as an innovative solution for individuals battling type 2 diabetes. This medication combines three powerful ingredients: Teneligliptin (20mg), Pioglitazone (15mg), and Extended Release Metformin Hydrochloride (500mg). This article delves into the composition, mechanism of action, benefits, dosage guidelines, side effects, and pricing of TENELIGOLD PM 500.

Key Ingredients

Teneligliptin (20mg)

Teneligliptin is a relatively new addition to the class of medications known as Dipeptidyl Peptidase-4 (DPP-4) inhibitors. It works by increasing the levels of incretin hormones, which help regulate glucose levels in the body. By inhibiting the DPP-4 enzyme, Teneligliptin prolongs the action of incretin hormones, leading to improved insulin secretion and decreased glucagon levels.

Pioglitazone (15mg)

Pioglitazone is a member of the thiazolidinedione class of medications. It primarily enhances insulin sensitivity in muscle and adipose tissue, facilitating better glucose uptake and utilization. Additionally, Pioglitazone has been shown to have a favorable effect on lipid profiles, contributing to overall metabolic health.

Extended Release Metformin Hydrochloride (500mg)

Metformin is a cornerstone in the treatment of type 2 diabetes. The extended-release formulation allows for a gradual release of the medication, which can help in reducing gastrointestinal side effects commonly associated with immediate-release formulations. Metformin works by decreasing hepatic glucose production, improving insulin sensitivity, and enhancing peripheral glucose uptake.

Mechanism of Action

The synergistic effect of these three components in TENELIGOLD PM 500 creates a multifaceted approach to managing blood glucose levels:

• Teneligliptin increases insulin secretion in response to meals, helping to lower postprandial blood sugar levels.
• Pioglitazone enhances insulin sensitivity, allowing the body to use insulin more effectively, thus improving overall glucose metabolism.
• Extended Release Metformin Hydrochloride reduces glucose production in the liver and improves the body’s response to insulin.

Together, these actions help maintain blood glucose levels within the target range, reducing the risk of diabetes-related complications.

Key Benefits

Comprehensive Glycemic Control

TENELIGOLD PM 500 offers a robust solution for individuals struggling to achieve glycemic control through diet and exercise alone. The combination of these three medications allows for effective management of both fasting and postprandial blood glucose levels.

Weight Management

Unlike some diabetes medications that can lead to weight gain, Pioglitazone has been associated with weight neutrality or modest weight loss in some patients. This can be particularly beneficial for individuals with type 2 diabetes who are overweight or obese.

Cardiovascular Protection

Research indicates that Pioglitazone may provide cardiovascular benefits by improving lipid profiles and reducing the risk of cardiovascular events. This is crucial, as individuals with diabetes are at a higher risk for cardiovascular diseases.

Reduced Risk of Hypoglycemia

The combination of Teneligliptin and Metformin is less likely to cause hypoglycemia compared to some other diabetes medications. This makes TENELIGOLD PM 500 a safer option for patients who are at risk for low blood sugar episodes.

Dosage Guidelines

The recommended dosage of TENELIGOLD PM 500 is one tablet per day, preferably taken with food to enhance absorption and minimize gastrointestinal side effects. It's essential for patients to adhere to their healthcare provider's instructions regarding dosing and administration.

Starting Dose

For most patients, the starting dose is typically one tablet of TENELIGOLD PM 500 daily. However, healthcare providers may adjust the dosage based on individual response and tolerance.

Monitoring

Regular monitoring of blood glucose levels is crucial for patients on TENELIGOLD PM 500. Healthcare providers may recommend periodic assessments of renal function, liver enzymes, and hematological parameters to ensure safety and efficacy.

Side Effects

While TENELIGOLD PM 500 is generally well-tolerated, some individuals may experience side effects. Common side effects may include:

• Gastrointestinal disturbances (nausea, diarrhea, abdominal pain)
• Weight gain (particularly with Pioglitazone)
• Edema (swelling due to fluid retention)
• Hypoglycemia (rare, but possible when combined with other diabetes medications)

Rare but Serious Side Effects

In rare cases, more serious side effects may occur, including:

• Liver dysfunction
• Heart failure (particularly with high doses of Pioglitazone)
• Lactic acidosis (associated with Metformin, particularly in patients with renal impairment)

Patients should seek immediate medical attention if they experience symptoms of severe side effects, such as unusual swelling, rapid weight gain, or persistent abdominal pain.

Pricing and Availability

The price of TENELIGOLD PM 500 may vary based on location, pharmacy, and health insurance coverage. On average, a month's supply can cost between INR 600 to INR 1200 in India, depending on the dosage and specific pharmacy pricing. It's advisable for patients to check with their healthcare provider or pharmacist for specific pricing details and potential discounts.

Conclusion

TENELIGOLD PM 500 represents a significant advancement in the management of type 2 diabetes. With its combination of Teneligliptin (20mg), Pioglitazone (15mg), and Extended Release Metformin Hydrochloride (500mg), this medication offers a comprehensive approach to achieving glycemic control while minimizing side effects. As with any medication, patients should work closely with their healthcare providers to determine the most appropriate treatment plan based on their individual needs and health status. For those seeking effective diabetes management, TENELIGOLD PM 500 may offer the support needed to lead a healthier, more balanced life. Always consult a healthcare professional before starting any new medication or making changes to your diabetes management plan. Steris Healthcare Pvt Ltd, operating as Sterispharma since its founding by expert professionals in the pharmaceutical industry in February 2018, is based in Navi Mumbai. The company is certified by WHO, GMP, and ISO, emphasizing its commitment to quality and safety. Sterispharma focuses on providing high-quality drugs at affordable prices throughout India, adhering strictly to WHO guidelines. Offering the convenience of an online pharmacy, customers can easily purchase medicines with home delivery options available. Sterispharma's mission is to supply a broad range of healthcare products to meet the diverse needs of the medical community. From advanced treatments and medications for rare conditions to essential health necessities, Sterispharma aims to serve the extensive demands of the healthcare industry. You can order medicines from Sterispharma through their websites, Sterisonline  ,  Sterisindia and Sterispharma. Their extensive product lineup includes treatments for Cardiology, Asthma, Respiratory Issues, Nasal Conditions, Diabetes, Endocrinology, Gastroenterology, Orthopedics, Anti-infectives/Antibiotics, General Medicine, Urology, Neurology, Nephrology, Oncology, Gynecology, Pediatrics, Dental Care, and Dermatology. 

For further information 

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