Teneligliptin 20mg, Pioglitazone 15mg & Extended Release Metformin Hydrochloride 500mg ..

Type 2 Diabetes Mellitus (T2DM) is one of the most rapidly growing chronic health conditions in India, affecting millions of people across urban and rural populations. Poor glycaemic control can lead to serious complications such as heart disease, kidney damage, nerve problems, and vision loss. Effective diabetes management often requires combination therapy that targets multiple pathways involved in glucose regulation.

TENELIGOLD PM 500 is a scientifically formulated oral anti-diabetic medicine containing Teneligliptin 20 mg, Pioglitazone 15 mg, and Extended Release Metformin Hydrochloride 500 mg. This triple-drug combination is designed to provide comprehensive blood sugar control by improving insulin sensitivity, reducing glucose production, and enhancing insulin secretion.

Prescribed widely by diabetologists and physicians in India, TENELIGOLD PM 500 helps patients achieve better glycaemic control with improved treatment adherence. This article provides a complete overview of TENELIGOLD PM 500 uses, benefits, mechanism of action, dosage, side effects, precautions, interactions, and clinical importance.

Composition of TENELIGOLD PM 500

Each tablet of TENELIGOLD PM 500 contains:

• Teneligliptin – 20 mg

• Pioglitazone – 15 mg

• Metformin Hydrochloride (Extended Release) – 500 mg

This balanced combination addresses insulin resistance, beta-cell dysfunction, and excessive glucose production.

Understanding the Components of TENELIGOLD PM 500

Teneligliptin 20 mg – DPP-4 Inhibitor

Teneligliptin belongs to the class of DPP-4 inhibitors. It works by increasing levels of incretin hormones, which:

• Stimulate insulin secretion in a glucose-dependent manner

• Suppress glucagon release

• Reduce post-meal blood sugar spikes

• Lower risk of hypoglycaemia

Teneligliptin is well-suited for Indian patients due to its metabolic stability and cardiovascular safety profile.

Pioglitazone 15 mg – Insulin Sensitizer

Pioglitazone is a thiazolidinedione (TZD) that improves insulin sensitivity by acting on adipose tissue, muscle, and liver.

Key benefits include:

• Enhanced glucose uptake by cells

• Reduced insulin resistance

• Improved lipid profile

• Long-term beta-cell protection

Metformin Hydrochloride ER 500 mg – Biguanide

Metformin is the first-line therapy for Type 2 Diabetes. The extended-release formulation offers sustained action with improved gastrointestinal tolerance.

Metformin works by:

• Reducing hepatic glucose production

• Improving peripheral insulin sensitivity

• Decreasing intestinal glucose absorption

• Supporting weight neutrality or mild weight loss

Uses of TENELIGOLD PM 500 Tablet

TENELIGOLD PM 500 is indicated for:

1. Type 2 Diabetes Mellitus

• For patients with inadequate glycaemic control on single or dual oral anti-diabetic therapy

• Helps control both fasting and postprandial blood glucose levels

2. Diabetes with Insulin Resistance

• Pioglitazone improves insulin sensitivity

• Especially useful in overweight or obese patients with high insulin resistance

3. Long-Term Glycaemic Management

• Helps reduce HbA1c levels

• Prevents long-term microvascular and macrovascular complications

Benefits of TENELIGOLD PM 500

TENELIGOLD PM 500 offers multiple clinical and patient-centric benefits:

• Comprehensive blood glucose control

• Improves insulin sensitivity and beta-cell function

• Reduces post-meal glucose spikes

• Extended-release metformin improves GI tolerance

• Low risk of hypoglycaemia when used appropriately

• Convenient once-daily dosing

• Improves patient compliance

How TENELIGOLD PM 500 Works (Mechanism of Action)

TENELIGOLD PM 500 works through three complementary mechanisms:

1. Enhanced Insulin Secretion

Teneligliptin increases incretin hormones, leading to glucose-dependent insulin release.

2. Improved Insulin Sensitivity

Pioglitazone activates PPAR-γ receptors, making body tissues more responsive to insulin.

3. Reduced Glucose Production

Metformin ER reduces hepatic glucose output and improves peripheral glucose uptake.

Together, these actions result in stable, sustained glycaemic control throughout the day.

Dosage and Administration

Recommended Dosage

• One tablet once daily, usually taken with the main meal

• Dosage should be individualized based on blood glucose levels and patient response

Administration Guidelines

• Swallow tablet whole; do not crush or chew

• Take at the same time each day

• Follow dietary and lifestyle advice prescribed by your doctor

Regular blood sugar monitoring is essential.

Side Effects of TENELIGOLD PM 500

Most patients tolerate TENELIGOLD PM 500 well. However, some side effects may occur.

Common Side Effects

• Nausea

• Diarrhoea

• Abdominal discomfort

• Headache

• Mild weight gain (pioglitazone-related)

Less Common Side Effects

• Peripheral edema

• Dizziness

• Fatigue

Rare but Serious Side Effects

• Hypoglycaemia (rare unless combined with other agents)

• Fluid retention or heart failure risk (pioglitazone)

• Lactic acidosis (very rare, metformin-related)

• Liver enzyme elevation

Seek medical attention if serious symptoms appear.

Precautions and Warnings

Before starting TENELIGOLD PM 500, inform your doctor if you have:

• Heart failure or fluid retention

• Liver or kidney disease

• History of bladder cancer

• Alcohol use disorder

• Severe infections or dehydration

Important Safety Advice

• Not recommended in severe renal impairment

• Regular monitoring of kidney and liver function is advised

• Avoid excessive alcohol intake

Drug Interactions

TENELIGOLD PM 500 may interact with:

• Insulin or sulfonylureas

• Diuretics

• Corticosteroids

• Thyroid medications

• Certain antibiotics and antifungals

Always disclose all medicines and supplements to your healthcare provider.

Use in Special Populations

Elderly Patients

Use with caution; renal function monitoring is essential.

Pregnancy and Breastfeeding

Not recommended unless clearly prescribed by a doctor.

Patients with Kidney Disease

Dose adjustment or alternative therapy may be required.

Lifestyle Measures Along with TENELIGOLD PM 500

For best results, medicine should be combined with:

• Balanced diabetic diet

• Regular physical activity

• Weight management

• Smoking cessation

• Regular blood sugar and HbA1c monitoring

Why Choose TENELIGOLD PM 500 from Steris Healthcare?

Steris Healthcare is committed to delivering high-quality, reliable, and patient-focused pharmaceutical solutions.

Key Advantages

• Scientifically balanced triple-drug combination

• Extended-release metformin for better tolerance

• Manufactured under strict quality standards

• Trusted by physicians and diabetologists across India

• Designed for long-term diabetes management

Storage Instructions

• Store at room temperature

• Protect from moisture and heat

• Keep out of reach of children

• Do not use after expiry date

Importance of Early and Effective Diabetes Control

Uncontrolled diabetes can lead to:

• Cardiovascular disease

• Kidney failure

• Neuropathy

• Retinopathy

• Reduced life expectancy

Combination therapies like TENELIGOLD PM 500 help achieve early, sustained glycaemic control, reducing long-term complications.

Conclusion

TENELIGOLD PM 500 Tablet, containing Teneligliptin 20 mg, Pioglitazone 15 mg, and Metformin Hydrochloride ER 500 mg, is a comprehensive and effective oral anti-diabetic therapy for patients with Type 2 Diabetes Mellitus. By targeting multiple defects in glucose metabolism, it helps achieve stable blood sugar control, improves insulin sensitivity, and enhances patient adherence.

Frequently Asked Questions 

Is TENELIGOLD PM 500 suitable for long-term use?

Yes, when taken under medical supervision with regular monitoring.

Does TENELIGOLD PM 500 cause weight gain?

Pioglitazone may cause mild weight gain, but metformin helps balance this effect.

Can TENELIGOLD PM 500 replace insulin?

It is used before insulin in many patients but does not replace insulin in advanced diabetes.

Is this medicine safe for heart patients?

Use cautiously in patients with heart failure; doctor supervision is required.

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