Tacrolimus 1 mg caps

Introduction

TACRENOLIME 1 is a highly specialized immunosuppressant medicine containing Tacrolimus 1 mg caps in capsule form. It is widely used in organ transplant patients to prevent organ rejection and in certain autoimmune diseases when other treatments are ineffective.

Manufactured under stringent standards by Steris Healthcare, TACRENOLIME 1 ensures consistent bioavailability, reliable immunosuppression, and reduced organ rejection risk.

Composition

• Active Ingredient: Tacrolimus 1 mg

• Form: Capsule

• Brand Name: TACRENOLIME 1

• Manufacturer: Steris Healthcare Pvt. Ltd.

What is Tacrolimus 1 mg Used For?

Tacrolimus 1 mg capsules are prescribed for:

• Prevention of organ rejection in:

  • Kidney transplant

  • Liver transplant

  • Heart transplant

• Treatment of autoimmune diseases, such as:

  • Severe atopic dermatitis (off-label)

  • Ulcerative colitis (off-label)

  • Lupus nephritis

  • Rheumatoid arthritis (off-label)

It is often used in combination with corticosteroids and other immunosuppressants like mycophenolate mofetil or azathioprine.

How Tacrolimus Works (Mechanism of Action)

Tacrolimus is a calcineurin inhibitor that:

1. Suppresses T-lymphocyte activation, which is crucial in immune responses leading to organ rejection.

2. Inhibits interleukin-2 (IL-2) production, thus reducing the immune system’s attack on transplanted organs or healthy tissues in autoimmune diseases.

This helps in prolonging graft survival and minimizing inflammation in autoimmune conditions.

Dosage of Tacrolimus 1 mg

TACRENOLIME 1 should be taken on an empty stomach (1 hour before or 2 hours after food) to ensure optimal absorption. Blood level monitoring is essential to maintain therapeutic range.

Tacrolimus 1 mg Side Effects

Common Side Effects:

• Tremors

• Headache

• Nausea

• Diarrhea

• Increased blood sugar

• High blood pressure

• Kidney dysfunction

Serious Side Effects:

• Infections (due to immunosuppression)

• Neurotoxicity

• Liver enzyme abnormalities

• Risk of malignancy (rare with long-term use)

Immediate medical attention is required if severe infection, fever, vision changes, or unusual fatigue occurs.

Precautions & Warnings

• Regular monitoring of tacrolimus blood levels is crucial.

• Monitor kidney function, liver enzymes, blood pressure, and glucose during therapy.

• Avoid grapefruit juice – it increases tacrolimus levels.

• Not recommended during pregnancy or lactation unless clearly needed.

Drug Interactions

Avoid combining tacrolimus with:

• Ketoconazole, Itraconazole

• Erythromycin, Clarithromycin

• Rifampin, Phenytoin

• Cyclosporine (avoid dual calcineurin inhibitors)

• NSAIDs (increase kidney risk)

Always consult your doctor for drug adjustment or substitution.

Why Choose TACRENOLIME 1 by Steris Healthcare?

TACRENOLIME 1 offers accurate dosing, pharmaceutical-grade stability, and extended shelf life, making it one of the most reliable tacrolimus capsules in India.