Pregabalin  75 mg ' ' ' ' ' ' ''

Pregabalin  75 mg

PREGABRIAL 75

Pregabalin is a medication primarily used to treat neuropathic pain, epilepsy, generalized anxiety disorder (GAD), and fibromyalgia. It belongs to the class of medications known as gabapentinoids, which work by modulating calcium channels in the central nervous system.

Here are some key points about pregabalin:

1. Mechanism of Action: Pregabalin binds to the alpha-2-delta subunit of voltage-gated calcium channels in the central nervous system. This action reduces the release of neurotransmitters such as glutamate, norepinephrine, and substance P, thereby reducing the excitability of neurons.

2. Medical Uses:

   • Neuropathic pain: Pregabalin is FDA-approved for the treatment of neuropathic pain associated with diabetic peripheral neuropathy, postherpetic neuralgia, and spinal cord injury.
   • Epilepsy: It is used as an adjunctive therapy for partial onset seizures in adults.
   • Generalized Anxiety Disorder (GAD): Pregabalin is approved for the treatment of GAD in several countries.
   • Fibromyalgia: It is also used to manage fibromyalgia, a condition characterized by widespread musculoskeletal pain, fatigue, and sleep disturbances.