Pregabalin and Nortriptyline Tablets Uses in Neuropathic Pain & Fibromyalgia

PREGABRIAL NT is a clinically established combination therapy designed for patients suffering from chronic neuropathic pain. Formulated with Pregabalin 75 mg and Nortriptyline 10 mg, the tablet offers dual-action relief by targeting damaged nerves and stabilizing pain-signalling pathways. Neuropathic pain can arise due to diabetes, nerve injuries, viral infections, or chronic conditions such as fibromyalgia. PREGABRIAL NT helps reduce burning sensations, tingling, muscle stiffness, and radiating pain that affect daily life.

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What is PREGABRIAL NT?

PREGABRIAL NT is a prescription medication formulated to control nerve-related (neuropathic) pain. The combination of Pregabalin and Nortriptyline is widely recommended when single-drug therapy does not provide adequate relief. The two medicines complement each other by reducing nerve sensitivity, calming hyperactive nerve cells, and improving overall pain tolerance. This ensures a more stable and long-lasting therapeutic effect compared to monotherapy.

Composition of PREGABRIAL NT

Each film-coated tablet contains:

• Pregabalin – 75 mg

• Nortriptyline – 10 mg

Both ingredients work through different mechanisms, ensuring effective nerve-pain management.

How PREGABRIAL NT Works

1. Pregabalin 75 mg

Pregabalin is known for its role in controlling nerve excitability. It binds to specific calcium channels in the central nervous system, thereby reducing the release of chemicals responsible for sending pain signals.
Its functions include:

• Reducing symptoms of nerve irritation

• Controlling burning, stabbing, or shooting pain

• Stabilizing nerve activity

• Improving sleep in patients experiencing chronic discomfort

2. Nortriptyline 10 mg

Nortriptyline is a tricyclic antidepressant with proven benefits in neuropathic pain. It enhances levels of norepinephrine and serotonin—neurotransmitters that regulate pain pathways.
It helps by:

• Improving mood and reducing anxiety associated with chronic pain

• Enhancing the effectiveness of Pregabalin

• Modulating pain signals at the spinal and brain level

• Supporting better sleep quality

Together, the combination works synergistically to offer comprehensive relief from neuropathic pain.

Uses of PREGABRIAL NT

PREGABRIAL NT is widely prescribed for several nerve-damage-related conditions, including:

1. Diabetic Neuropathy

Common among long-term diabetic patients, diabetic neuropathy causes burning, tingling, numbness, and nerve pain in the legs and hands. PREGABRIAL NT effectively reduces these symptoms.

2. Post-Herpetic Neuralgia

This is the long-lasting nerve pain that persists after a shingles infection. The combination helps patients achieve sustained relief from stabbing or throbbing pain.

3. Fibromyalgia

People with fibromyalgia often experience widespread chronic pain. This tablet helps reduce nerve sensitivity and muscle discomfort.

4. Sciatica & Radiculopathy

Pain radiating from the lower back to the legs, caused by nerve compression, can be well-managed with this combination.

5. Trigeminal Neuralgia

A severe facial pain condition. This medicine helps reduce the frequency and intensity of pain attacks.

6. General Neuropathic Pain

PREGABRIAL NT is effective for nerve pain caused by injuries, vitamin deficiencies, alcohol-induced nerve damage, or chronic nerve inflammation.

Benefits of PREGABRIAL NT

1. Dual Mechanism for Stronger Relief

The combination of Pregabalin and Nortriptyline ensures faster and more extended relief than either drug alone.

2. Improves Sleep Quality

Neuropathic pain often affects sleep. Both ingredients help induce restful sleep, enhancing overall wellbeing.

3. Reduces Sensory Nerve Symptoms

Burning, tingling, numbness, and pin-prick sensations reduce significantly with regular use.

4. Enhances Mood & Mental Stability

Chronic pain can affect mood. Nortriptyline supports emotional balance, reducing anxiety and irritability.

5. Suitable for Long-Term Pain Management

Safe and effective for prolonged use under medical supervision.

6. Helps Improve Daily Functioning

Patients often notice improved mobility, comfort, and energy for regular activities.

Dosage & Administration

• Generally, doctors recommend one tablet once daily, preferably at bedtime.

• Dosage may vary based on the patient’s condition, severity of symptoms, and response to therapy.

• Tablets should be swallowed whole with water.

• Consistency is essential for desired results.

• Do not stop taking the medication abruptly; dose reduction should be supervised by a healthcare professional.

Side Effects of PREGABRIAL NT

Common and mild side effects include:

• Drowsiness

• Dizziness

• Dry mouth

• Constipation

• Blurred vision

• Increased appetite or weight

• Mild swelling in hands or feet

• Difficulty concentrating

These effects usually subside as the body adapts. Serious side effects are rare but require prompt medical attention.

Precautions & Warnings

1. Avoid Alcohol

Alcohol may worsen dizziness and drowsiness.

2. Use Cautiously in Kidney Patients

Dose adjustment may be necessary due to reduced drug clearance.

3. Pregnancy & Breastfeeding

Should be taken only if clearly needed and prescribed by a clinician.

4. Avoid Driving or Heavy Machinery

The medicine may reduce alertness.

5. Mental Health Monitoring

Patients with a history of depression should be monitored.

6. Drug Interactions

Inform your doctor if using antacids, antihistamines, antidepressants, or diabetes medicines.

Why Choose PREGABRIAL NT?

• Strong combination formula trusted for neuropathic pain

• Manufactured under high-quality standards

• Supports better sleep and improved physical comfort

• Suitable for chronic nerve pain conditions

• Provides faster, long-lasting symptomatic relief

• Recommended by healthcare professionals across India

How Long Does It Take to Show Results?

Most patients experience noticeable relief within 1–2 weeks, while full therapeutic benefit may take 4–6 weeks. Consistent use enhances long-term outcomes.

Lifestyle Support Along with PREGABRIAL NT

To maximize benefits, doctors often recommend:

• Maintaining optimal blood sugar levels

• Physiotherapy for improving nerve and muscle strength

• Adequate hydration

• Avoiding smoking and alcohol

• Consuming a balanced diet rich in B vitamins

These supportive measures help accelerate recovery and reduce flare-ups of neuropathic pain.

Storage Information

• Store below 25°C in a cool, dry place.

• Keep out of reach of children.

• Protect from moisture and direct sunlight.

Conclusion

PREGABRIAL NT (Pregabalin 75 mg + Nortriptyline 10 mg) offers a reliable and comprehensive solution for managing chronic neuropathic pain. With its dual-action mechanism, the tablet reduces nerve sensitivity, stabilizes mood, and enhances sleep quality, making daily life more comfortable for patients. Whether the pain arises from diabetes, nerve injury, shingles, or chronic nerve disorders, PREGABRIAL NT provides consistent and long-lasting relief when used under medical guidance.