Perindopril & Indapamide "

Perindopril & Indapamide
PERINDPRIM PLUS  
Perindopril and indapamide are two medications commonly used to treat hypertension (high blood pressure) and other cardiovascular conditions. They are often prescribed together in a single combination tablet to enhance their effectiveness and simplify treatment for patients with hypertension.
Perindopril is an angiotensin-converting enzyme (ACE) inhibitor. ACE inhibitors work by blocking the production of angiotensin II, a hormone that causes blood vessels to narrow (constrict) and promotes the release of another hormone called aldosterone, which leads to water and salt retention. By blocking the actions of angiotensin II, perindopril helps relax and widen blood vessels, reducing blood pressure and improving blood flow. Perindopril is also used in the treatment of heart failure and to reduce the risk of cardiovascular events in certain high-risk patients.
Indapamide is a thiazide-like diuretic. Diuretics, often referred to as "water pills," help the body eliminate excess salt and water through urine. Indapamide works by promoting the excretion of sodium and water from the kidneys, which reduces the overall volume of blood and helps lower blood pressure. Additionally, indapamide may have some vasodilatory effects, meaning it can help relax and widen blood vessels.
The combination of perindopril and indapamide is often prescribed to provide complementary effects in managing hypertension. The ACE inhibitor (perindopril) helps relax blood vessels and reduce fluid retention, while the diuretic (indapamide) helps eliminate excess salt and water from the body. This combination can lead to a more significant reduction in blood pressure than either medication alone.
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