Olmesartan (40mg), Amlodipine (5mg), HCTZ (12.5mg)```````

Hypertension, commonly known as high blood pressure, is one of the leading causes of cardiovascular morbidity and mortality in India. With rapid urbanization, sedentary lifestyles, unhealthy dietary habits, high salt intake, obesity, stress, and genetic predisposition, the burden of hypertension continues to rise across all age groups. What makes hypertension particularly dangerous is that it often progresses silently, causing serious damage to vital organs such as the heart, brain, kidneys, and blood vessels without obvious symptoms.

For many patients, controlling blood pressure with a single antihypertensive medicine is not sufficient. Clinical evidence shows that a significant proportion of hypertensive patients require combination therapy to achieve target blood pressure levels and reduce long-term complications. Triple-combination therapies are especially beneficial for patients with moderate to severe hypertension or those who remain uncontrolled on monotherapy or dual therapy.

TRIOLMISTRUM 40 is an advanced antihypertensive formulation that combines Olmesartan Medoxomil 40 mg, Amlodipine 5 mg, and Hydrochlorothiazide (HCTZ) 12.5 mg in a single tablet. Each component works through a distinct and complementary mechanism to provide comprehensive blood pressure control. This synergistic approach not only lowers blood pressure effectively but also improves treatment adherence by reducing pill burden.

Designed for long-term management,olmesartan medoxomil and hydrochlorothiazide tablets plays a crucial role in minimizing the risk of cardiovascular events such as heart attack and stroke, while also offering renal protection when used under medical supervision.

Uses of TRIOLMISTRUM 40

TRIOLMISTRUM 40 is primarily indicated for the treatment and management of essential hypertension in adult patients who require multiple antihypertensive agents for adequate blood pressure control.

Primary Uses

• Management of moderate to severe hypertension

• Treatment of patients not adequately controlled on single or dual antihypertensive therapy

• Long-term maintenance of stable blood pressure levels

• Reduction of hypertension-related cardiovascular risks

Prevention of Hypertension-Related Complications

By maintaining blood pressure within the recommended range, olmesartan medoxomil and hydrochlorothiazide tablets uses helps reduce the risk of:

• Stroke

• Myocardial infarction (heart attack)

• Heart failure

• Chronic kidney disease

• Peripheral vascular disease

Role of Individual Components

• Olmesartan Medoxomil (40 mg): An angiotensin II receptor blocker (ARB) that prevents vasoconstriction and aldosterone secretion, leading to relaxation of blood vessels and reduced blood pressure. It also offers protective benefits for the heart and kidneys.

• Amlodipine (5 mg): A calcium channel blocker that relaxes vascular smooth muscles, improving blood flow and decreasing the workload on the heart.

• Hydrochlorothiazide (12.5 mg): A thiazide diuretic that promotes the elimination of excess salt and water from the body, reducing blood volume and lowering blood pressure.

The combined action of these three agents ensures effective, sustained, and well-balanced blood pressure control.

Benefits of TRIOLMISTRUM 40

TRIOLMISTRUM 40 offers several therapeutic and practical benefits that make it a preferred option in hypertension management.

1. Triple-Mechanism Blood Pressure Control

Targets three different physiological pathways involved in hypertension, resulting in superior and consistent blood pressure reduction.

2. Effective in Resistant Hypertension

Ideal for patients whose blood pressure remains uncontrolled with monotherapy or two-drug combinations.

3. Sustained 24-Hour Action

Provides round-the-clock blood pressure control with once-daily dosing.

4. Cardiovascular Protection

Helps reduce the risk of heart attack, stroke, and other cardiovascular events associated with uncontrolled hypertension.

5. Renal Protective Effects

Olmesartan contributes to kidney protection, especially in patients at risk of renal complications due to hypertension.

6. Reduced Fluid Retention

HCTZ helps prevent fluid overload, reducing pressure on the heart and blood vessels.

7. Improved Patient Compliance

Single-tablet combination simplifies treatment regimens and improves adherence.

8. Suitable for Long-Term Therapy

Well-tolerated formulation supports long-term use under medical supervision.

olmesartan medoxomil and hydrochlorothiazide tablets price: for price please contact at steris healthcare.

Dosage of TRIOLMISTRUM 40

The dosage of TRIOLMISTRUM 40 should be determined by a qualified healthcare professional based on the patient’s clinical condition and blood pressure response.

Recommended Dosage

• One tablet once daily, or as directed by the physician

• Can be taken with or without food

• Preferably taken at the same time each day

Administration Guidelines

• Swallow the tablet whole with water

• Do not crush, chew, or split the tablet

• Continue treatment even if blood pressure readings improve

• Combine medication with lifestyle modifications such as:

  • Reduced salt intake

  • Regular physical activity

  • Weight management

  • Stress reduction

Missed Dose

• Take the missed dose as soon as remembered

• Skip the missed dose if it is close to the next scheduled dose

• Do not take a double dose

Side Effects of TRIOLMISTRUM 40

olmesartan medoxomil and hydrochlorothiazide is generally well tolerated when taken as prescribed. However, like all medicines, it may cause side effects in some patients.

Common Side Effects

• Dizziness or light-headedness

• Headache

• Fatigue

• Increased urination

• Swelling of ankles or feet

Less Common Side Effects

• Palpitations

• Muscle cramps

• Nausea

• Dry mouth

Rare but Serious Side Effects

• Excessive lowering of blood pressure

• Electrolyte imbalance (low potassium or sodium levels)

• Changes in kidney function

• Severe allergic reactions such as rash, swelling, or difficulty breathing

Patients experiencing severe or persistent side effects should seek medical attention promptly.

Warnings

• Not recommended during pregnancy, particularly in the second and third trimesters

• Use with caution in patients with severe kidney or liver impairment

• Blood pressure may drop excessively at the start of therapy

• Regular monitoring of blood pressure, kidney function, and electrolytes is advised

• Do not discontinue the medication abruptly without medical advice

Precautions

• Inform your doctor about any history of heart, kidney, or liver disease

• Monitor blood pressure regularly at home or during follow-up visits

• Avoid excessive alcohol consumption, as it may enhance dizziness

• Maintain proper hydration, especially in hot climates

• Elderly patients may require closer monitoring

• Inform your doctor about all other medications or supplements being taken

Conclusion

TRIOLMISTRUM 40, containing Olmesartan 40 mg, Amlodipine 5 mg, and Hydrochlorothiazide 12.5 mg, is a powerful triple-combination antihypertensive therapy designed for patients who require comprehensive blood pressure control. By addressing multiple mechanisms involved in hypertension, it ensures consistent and effective reduction in blood pressure while minimizing the risk of long-term complications.

Its proven efficacy, convenience of once-daily dosing, and ability to improve patient compliance make TRIOLMISTRUM 40 a valuable choice in modern hypertension management. When combined with healthy lifestyle modifications and regular medical follow-up, it supports long-term cardiovascular health and an improved quality of life.

Frequently Asked Questions (FAQs)

Q1. What is TRIOLMISTRUM 40 used for?

TRIOLMISTRUM 40 is used to treat high blood pressure and reduce the risk of cardiovascular and renal complications.

Q2. Can TRIOLMISTRUM 40 be taken daily?

Yes, it is designed for once-daily use as prescribed by a healthcare professional.

Q3. Does TRIOLMISTRUM 40 cause frequent urination?

Yes, due to the presence of HCTZ, increased urination may occur, especially at the beginning of therapy.

Q4. Is TRIOLMISTRUM 40 safe for long-term use?

Yes, it is suitable for long-term use when taken under medical supervision with regular monitoring.

Q5. Can diabetic patients take TRIOLMISTRUM 40?

It can be prescribed to diabetic patients, but blood sugar levels and kidney function should be monitored regularly.