Cinitapride (1mg)

Introduction

CT PRIDE 1 is a specialized gastroprokinetic agent containing Cinitapride 1 mg, designed to provide effective and well-tolerated relief from symptoms of gastric motility disorders. Cinitapride enhances the natural movement of the gastrointestinal tract, thereby relieving bloating, early satiety, postprandial fullness, nausea, and vomiting.In today’s clinical settings, functional gastrointestinal complaints like non-ulcer dyspepsia, GERD, and diabetic gastroparesis are increasingly common. CT PRIDE 1 provides a targeted, low-dose solution that optimizes gastric emptying without affecting gastric acid secretion.

Composition

Each film-coated tablet contains:

• Cinitapride (as hydrogen tartrate) – 1 mg

Mechanism of Action

Cinitapride works through dual action:

• 5-HT4 receptor agonist: Stimulates serotonin receptors in the enteric nervous system, enhancing acetylcholine release that promotes gastric and intestinal motility.

• 5-HT2 receptor antagonist: Inhibits receptors responsible for nausea and vomiting, giving it antiemetic properties.

This makes CT PRIDE 1 uniquely suited for managing both upper GI motility disorders and central nausea symptoms.

Clinical Indications

CT PRIDE 1 is indicated for the symptomatic treatment of:

• Functional dyspepsia

• Gastroesophageal reflux disease (GERD)

• Diabetic gastroparesis

• Non-ulcer dyspepsia

• Post-surgical gastric stasis

• Nausea and vomiting (functional or drug-induced)

• Delayed gastric emptying in Parkinson’s disease or chronic illnesses

Key Clinical Benefits

• Enhances GI motility without altering acid secretion

• Reduces bloating, fullness, belching, and flatulence

• Effective in reducing regurgitation and post-meal heaviness

• Helps in diabetic and idiopathic gastroparesis

• Can be co-administered with PPIs or H2 blockers

• Beneficial in functional gastrointestinal disorders (FGID) where no structural cause is found

• Well-tolerated with low central nervous system side effects

Dosage and Administration

Adults:

• 1 mg tablet three times daily

• Administer 15–30 minutes before meals

Children:

• Use only if prescribed by a physician (limited pediatric data)

Elderly:

• Start at a lower dose if necessary; monitor closely for side effects

Pharmacological Highlights

• Bioavailability: Rapidly absorbed orally

• Peak plasma time: 1 to 1.5 hours

• Half-life: Approximately 4–6 hours

• Metabolism: Hepatic

• Excretion: Primarily via urine

Safety Profile

CT PRIDE 1 is generally well-tolerated. Possible mild side effects may include:

• Headache

• Mild sedation or dizziness

• Dry mouth or abdominal cramps (rare)

• Diarrhea or restlessness in sensitive individuals

Contraindications:

• Intestinal obstruction or perforation

• Active GI bleeding

• Parkinson’s disease (use cautiously)

• Pregnancy and lactation unless clearly needed

Drug Interactions

• Use with anticholinergics or narcotics may reduce prokinetic effect

• Avoid with other serotonergic drugs without medical supervision

• Monitor with antidepressants or antipsychotics for additive CNS effects

Frequently Asked Questions (FAQs)

Q1. Is Cinitapride safe for long-term use?
Yes, under medical supervision, CT PRIDE 1 can be used for long-term symptomatic relief in functional GI disorders with low risk of dependence.

Q2. Can CT PRIDE 1 be used in GERD with PPI failure?
Absolutely. CT PRIDE 1 complements proton pump inhibitors by improving gastric emptying and reducing reflux symptoms, especially in PPI non-responders.

Q3. Is it effective in diabetic patients?
Yes, CT PRIDE 1 is commonly used to manage diabetic gastroparesis, which results from autonomic neuropathy affecting gastric motility.

Q4. Can CT PRIDE 1 help with post-meal bloating and heaviness?
Yes. Its prokinetic effect significantly reduces early satiety, postprandial bloating, and gas accumulation.

Q5. Is it sedating? Can I drive while taking it?
CT PRIDE 1 has minimal central effects. However, if you experience drowsiness, avoid driving or operating machinery.

Summary

CT PRIDE 1 (Cinitapride 1 mg) offers a focused, effective solution for patients experiencing upper GI motility dysfunction, acid reflux, and non-specific dyspeptic symptoms. Its dual action makes it stand out among prokinetics, combining enhanced gastric motility with anti-nausea benefits.With CT PRIDE 1, patients experience faster gastric emptying, reduced symptoms, and improved quality of life.

About The Author

STERIS HEALTHCARE PVT LTD

Steris Healthcare Pvt Ltd, known as Sterispharma, was founded in February 2018 by a team of experienced professionals in the pharmaceutical industry. Headquartered in Navi Mumbai, the company holds certifications from WHO, GMP, and ISO, reflecting its dedication to maintaining high standards of quality and safety. Sterispharma’s mission is to provide affordable, high-quality medications across India, strictly adhering to WHO guidelines. With the convenience of an online pharmacy, customers can easily order medicines with home delivery options.

For further information 

Email: info@sterispharma.com / contact@sterispharma.com

Call/WhatsApp: 8209542042 , 8824175417

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