BOSENTIME 62.5:Uses & Side effects and Precuations,Benefits and more..

Introduction

BOSENTIME 62.5 is a prescription medicine that contains Bosentan 62.5 mg, a dual endothelin receptor antagonist. It is primarily used in the treatment of Pulmonary Arterial Hypertension (PAH) — a progressive condition characterized by high blood pressure in the arteries of the lungs. Bosentan helps lower blood pressure in the lungs, improving the ability to exercise and slowing disease progression.

Composition of BOSENTIME 62.5

Each BOSENTIME 62.5 tablet contains:

• Bosentan 62.5 mg – an endothelin receptor antagonist

• Excipients – q.s.

• Dosage Form – Oral, film-coated tablet

Medical Uses of BOSENTIME 62.5

BOSENTIME 62.5 is indicated for:

• Pulmonary Arterial Hypertension (PAH) – WHO Group I

  • Improves exercise capacity

  • Slows disease progression

  • Enhances quality of life in patients with NYHA Functional Class II and III symptoms

• Systemic Sclerosis-associated Digital Ulcers (in some cases, off-label use)

Always use this medication under the supervision of a certified healthcare professional.

How BOSENTIME 62.5 (Bosentan 62.5 mg) Works

Bosentan acts as a dual endothelin receptor antagonist (ERA) that blocks the action of endothelin-1 (ET-1), a potent vasoconstrictor that narrows blood vessels and increases blood pressure. By blocking both ETA and ETB receptors, Bosentan promotes vasodilation and reduces pulmonary arterial pressure, thereby improving heart function and patient mobility.

Dosage and Administration

Initial Dose:

• 62.5 mg twice daily for the first 4 weeks

Maintenance Dose:

• After 4 weeks, increased to 125 mg twice daily, as tolerated

Route of Administration: Oral
Timing: With or without food

Note: Dosage adjustments may be required based on liver function, weight, or concurrent medications.

Side Effects of BOSENTIME 62.5

Common side effects:

• Headache

• Flushing

• Ankle swelling (peripheral edema)

• Nasal congestion

• Respiratory tract infection

• Abnormal liver function tests

Serious side effects (seek immediate medical help):

• Elevated liver enzymes or liver injury

• Hemoglobin level reduction

• Hypotension

• Anemia

Regular monitoring of liver function tests (LFTs) and hemoglobin levels is recommended during treatment.

Precautions and Warnings

1. Liver Toxicity: Monitor LFTs before and during treatment. Discontinue if ALT/AST >3x ULN with symptoms.

2. Pregnancy Risk (Category X): Contraindicated in pregnancy. Requires negative pregnancy test and effective contraception during and after therapy.

3. Hematological Effects: May cause anemia—monitor hemoglobin levels.

4. Drug Interactions: Avoid co-administration with cyclosporine A and glyburide due to increased risk of hepatotoxicity.

5. Pulmonary Veno-Occlusive Disease (PVOD): Not recommended in such cases.

Drug Interactions

Bosentan may interact with:

• Cyclosporine A – increased risk of liver injury

• Rifampin – may reduce bosentan levels

• Hormonal Contraceptives – decreased efficacy; use dual contraception

• Warfarin and other anticoagulants – monitor INR

Contraindications

• Pregnancy

• Liver impairment or elevated liver enzymes (>3x ULN)

• Hypersensitivity to Bosentan or any excipients

• Concurrent use with cyclosporine A or glyburide

Storage Instructions

• Store below 30°C in a dry place

• Protect from light and moisture

• Keep out of reach of children

Frequently Asked Questions (FAQs)

Q1. What is BOSENTIME 62.5 used for?

A: It is used for treating Pulmonary Arterial Hypertension (PAH) to improve exercise capacity and delay disease progression.

Q2. Can BOSENTIME 62.5 be taken during pregnancy?

A: No, Bosentan is contraindicated in pregnancy due to high teratogenic risk.

Q3. How long should I take BOSENTIME 62.5?

A: The duration depends on the condition and your doctor’s recommendation. Regular monitoring is essential.

Q4. Does BOSENTIME 62.5 affect the liver?

A: Yes, it may cause liver toxicity. Regular liver function tests are mandatory.

Q5. Can I use birth control pills while on BOSENTIME 62.5?

A: Hormonal contraceptives may be ineffective with Bosentan. Use an additional or alternative contraceptive method.

Conclusion

BOSENTIME 62.5 (Bosentan 62.5 mg tablet) plays a crucial role in the treatment of Pulmonary Arterial Hypertension, offering improved exercise tolerance and quality of life. However, it requires careful monitoring of liver function, blood counts, and strict pregnancy prevention measures. As a potent endothelin receptor antagonist, it must be used only under expert medical supervision.

About The Company

Steris Healthcare Pvt Ltd, widely recognized as Sterispharma, was established in February 2018 by a team of seasoned experts from the pharmaceutical sector. Based in Navi Mumbai, the company is proudly certified by WHO, GMP, and ISO, underscoring its unwavering commitment to quality and patient safety. Sterispharma is driven by a mission to make affordable, premium-quality medicines accessible throughout India, adhering strictly to WHO-recommended standards. Through its user-friendly online pharmacy platforms, customers can effortlessly order medications with home delivery services.

Sterispharma boasts an extensive portfolio of healthcare solutions, ranging from treatments for rare diseases to essential everyday healthcare needs. Their comprehensive product lineup addresses multiple therapeutic areas including Cardiology, Asthma, Respiratory Disorders, Nasal Care, Diabetes, Endocrinology, Gastroenterology, Orthopedics, Anti-infective/Antibiotic Therapy, General Medicine, Urology, Neurology, Nephrology, Oncology, Gynecology, Pediatrics, Dental Care, and Dermatology. Medications are easily available for online purchase through their official websites — Sterisonline, Sterisindia, and Sterispharma — offering a seamless and reliable healthcare experience.

For further information 

Email: info@sterispharma.com / contact@sterispharma.com

Call/WhatsApp: 8209542042 , 8824175417

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