TRIGLICLAGLAZE 30

TRIGLICLAGLAZE 30 is a powerful oral antidiabetic medication formulated with a combination of three well-established agents: Gliclazide, Pioglitazone, and Metformin. This triple-action therapy is designed for the effective management of type 2 diabetes mellitus in patients who require comprehensive glycemic control. By targeting multiple pathways of glucose metabolism, TRIGLICLAGLAZE 30 helps reduce blood sugar levels, improve insulin sensitivity, and enhance overall metabolic health.

What is TRIGLICLAGLAZE 30?

TRIGLICLAGLAZE 30 is an advanced fixed-dose combination tablet used in the treatment of type 2 diabetes mellitus. It integrates three active components:

• Gliclazide: A sulfonylurea that increases insulin secretion from the pancreas.

• Pioglitazone: A thiazolidinedione that improves the body’s response to insulin and reduces insulin resistance.

• Metformin: A biguanide that lowers glucose production in the liver and improves glucose uptake by muscles.

Together, these ingredients help maintain optimal blood glucose levels and delay complications related to uncontrolled diabetes.

Uses of TRIGLICLAGLAZE 30

TRIGLICLAGLAZE 30 is used for:

• Managing type 2 diabetes mellitus, especially in adults whose blood glucose levels are inadequately controlled with diet, exercise, and monotherapy

• Reducing insulin resistance

• Controlling fasting and postprandial blood sugar

• Delaying diabetes-related complications such as neuropathy, nephropathy, and retinopathy

• Improving overall glycemic control in combination with lifestyle changes

Side Effects of TRIGLICLAGLAZE 30

Like all medicines, TRIGLICLAGLAZE 30 may cause some side effects, although not everyone gets them. Common and less common side effects may include:

• Hypoglycemia (low blood sugar), especially when meals are skipped

• Gastrointestinal disturbances like nausea, vomiting, or diarrhea

• Weight gain (primarily due to Pioglitazone or Gliclazide)

• Headache or dizziness

• Edema or fluid retention

• Muscle pain or fatigue

• Rarely, lactic acidosis (a serious condition related to Metformin overdose)

Precautions Before Using TRIGLICLAGLAZE 30

Before starting this medication, it is important to inform your doctor about any of the following:

• If you have a history of heart failure, liver disease, or kidney dysfunction

• If you drink alcohol regularly, as it increases the risk of lactic acidosis with Metformin

• If you are pregnant, planning to become pregnant, or breastfeeding

• If you are undergoing surgery or procedures that require fasting

• If you have any allergies to sulfonylureas, thiazolidinediones, or biguanides

• If you have a history of bladder cancer (related to Pioglitazone)

Regular monitoring of blood sugar, liver function, and kidney function is advised during treatment.

Drug Interactions: What Drugs Interact with TRIGLICLAGLAZE 30?

Several drugs can interact with Gliclazide, Pioglitazone, and Metformin, altering their effects or increasing side effect risks. These include:

• Other antidiabetic medications (insulin, sulfonylureas, etc.), which can increase the risk of hypoglycemia

• Diuretics (e.g., furosemide), which may affect blood glucose control

• Beta-blockers, which can mask symptoms of hypoglycemia

• Corticosteroids and oral contraceptives, which may increase blood sugar levels

• Iodinated contrast agents (used in radiographic imaging) with Metformin may increase the risk of lactic acidosis

• ACE inhibitors or ARBs, which may enhance the hypoglycemic effect

• Antifungal agents and antibiotics like fluconazole or ciprofloxacin, which can alter drug metabolism

Always inform your doctor about all the medications and supplements you are taking to avoid harmful interactions.

Conclusion

TRIGLICLAGLAZE 30 is a comprehensive solution for managing type 2 diabetes in patients requiring multifaceted glucose control. With its triple-action formula of Gliclazide, Pioglitazone, and Metformin, it targets insulin secretion, sensitivity, and glucose production—offering a balanced approach to diabetes care. Regular monitoring, a proper diet, exercise, and adherence to the prescribed dose will help you get the best out of this medication.