TOLVAPTORIS 15

TOLVAPTORIS 15 is an advanced prescription medication containing Tolvaptan 15 mg, a selective vasopressin V2-receptor antagonist. It is primarily used in the treatment of hyponatremia (low blood sodium levels) in patients with conditions such as syndrome of inappropriate antidiuretic hormone secretion (SIADH) and congestive heart failure. TOLVAPTORIS 15 is also indicated for managing autosomal dominant polycystic kidney disease (ADPKD) to slow the progression of kidney function decline.

This medication is designed for hospital and specialist use under the supervision of a healthcare provider, offering targeted action with a clear therapeutic benefit in fluid balance and renal function.

Key Ingredient:

• Tolvaptan 15 mg:
  Tolvaptan is a vasopressin receptor antagonist, specifically targeting V2 receptors in the kidneys. By inhibiting vasopressin action, it promotes free water excretion (aquaresis) without causing significant loss of sodium or other electrolytes, making it highly effective in treating euvolemic and hypervolemic hyponatremia.

Key Benefits of TOLVAPTORIS 15:

• Effectively treats clinically significant hyponatremia associated with SIADH, cirrhosis, or heart failure

• Helps restore serum sodium levels safely and gradually

• Used as part of treatment in ADPKD to slow the rate of kidney function decline

• Promotes free water excretion without disturbing electrolyte balance

• Oral tablet form ensures convenient administration under medical supervision

• A well-researched option with proven efficacy in fluid and electrolyte disorders

How Does It Work?

Tolvaptan works by blocking vasopressin V2 receptors in the renal collecting ducts. Vasopressin (antidiuretic hormone) normally promotes water retention in the kidneys. By antagonizing this action, Tolvaptan allows increased excretion of free water (aquaresis) while retaining sodium and other essential electrolytes. This mechanism helps correct low sodium levels without causing dehydration or electrolyte disturbances.

In ADPKD, Tolvaptan reduces cyst growth and preserves kidney function by modulating the cAMP pathway, influenced by vasopressin signaling.

Directions for Use:

• TOLVAPTORIS 15 should only be used under the guidance of a registered medical practitioner.

• The dosage and duration are determined based on the patient’s condition, sodium levels, and overall fluid status.

• Tablets are typically taken once daily, with or without food.

• Adequate fluid intake must be maintained to avoid dehydration.

• Monitoring of serum sodium and liver function is essential during therapy.

Side Effects:

Like all medications, TOLVAPTORIS 15 may cause some side effects. Common or possible side effects include:

• Increased thirst or dry mouth

• Frequent urination (due to aquaresis)

• Fatigue or dizziness

• Nausea

• Elevated liver enzymes (requires monitoring)

• Dehydration if fluid intake is not maintained

• Headache

Patients must be monitored closely, particularly during initial treatment days, to avoid overcorrection of sodium levels or hepatic side effects.