ST-GLIPTIN M 100/ 500

ST-Gliptin M 100/500 is a fixed-dose combination tablet that puts two well-established diabetes medicines into one tablet. Each works in a different way, so together they address more than one cause of high blood sugar.

Sitagliptin blocks an enzyme called DPP-4. This keeps your natural incretin hormones active for longer after meals. The pancreas then releases more insulin when blood sugar rises, and the liver releases less sugar. Because it works in a glucose-dependent way, it has a low tendency to cause hypoglycemia (low blood sugar) on its own.

Metformin hydrochloride is the most widely used first-line diabetes medicine worldwide. It lowers the amount of sugar the liver produces and helps muscles and tissues respond better to insulin. It generally does not cause weight gain, and in many people it is weight-neutral or modestly weight-lowering.

Why combine them? Type 2 diabetes involves insulin resistance, a declining insulin response and excess sugar from the liver, all at once. Metformin tackles the liver and insulin resistance, while sitagliptin supports the insulin response after meals. Many patients on metformin alone need a second medicine over time, and a single tablet means fewer pills to carry and remember.

Product at a glance: ST-Gliptin M 100/500 is a tablet containing sitagliptin and metformin hydrochloride for adults with type 2 diabetes, taken with meals as prescribed. It is marketed by Steris Healthcare Pvt. Ltd. (Jaipur, India), WHO-GMP and ISO certified, in packs of 15 tablets.

Product Information

Why Is ST-Gliptin M 100/500 Important?

India has one of the largest populations of people with diabetes in the world, and many more have pre-diabetes. Diabetes is a lifelong, progressive condition. Over time, blood sugar often becomes harder to control with a single medicine. Persistently high sugar can quietly damage:

• Eyes (diabetic retinopathy and vision loss)
• Kidneys (diabetic nephropathy)
• Nerves (neuropathy, with tingling, numbness and foot ulcers)
• Heart and blood vessels (heart attack, stroke, poor circulation)
• Wound healing and resistance to infection

Good control early, and keeping it steady, is the most effective way to lower these risks. Combination therapy is a recognised approach when one medicine is not enough, and it can help patients reach their HbA1c targets without a rapid jump in the number of tablets.

Why a fixed-dose tablet helps in real life: many Indian patients take medicines for blood pressure, cholesterol and other conditions as well. A long list of tablets makes missed doses more likely. Combining two diabetes medicines into one tablet can make the routine simpler and support adherence, which is often the biggest factor in long-term control.

Why this matters for Indian patients and clinics: diabetologists, physicians and general practitioners need dependable, GMP-manufactured combination tablets, and pharmacies and hospitals need consistent supply for chronic-therapy patients.

Key Benefits 

• Two complementary actions in one tablet: metformin reduces liver sugar output and insulin resistance, while sitagliptin boosts the post-meal insulin response.
• Improves HbA1c and blood sugar: helps lower both fasting and after-meal sugar when used with diet and exercise.
• Low risk of hypoglycemia on its own: both components act mainly when sugar is high, although the risk rises if combined with insulin or a sulfonylurea.
• Generally weight-neutral: it does not usually cause weight gain.
• Fewer tablets: a single combined tablet can simplify the regimen and help adherence.
• Long clinical track record: both ingredients are widely studied and used.
• Can be part of a larger plan: doctors may add other medicines as needed.
• Made under WHO-GMP and ISO standards: assured manufacturing quality from Steris Healthcare.

Precautions Before Taking 

Tell your doctor before starting if you:

• Have kidney disease. Metformin is cleared by the kidneys and can build up. This product is not suitable when eGFR is below 30. Kidney function should be tested before starting and at least yearly (more often if reduced).
• Have liver disease, heavy alcohol use or heart or lung problems causing low oxygen. These raise the risk of lactic acidosis, a rare but serious condition.
• Have a history of pancreatitis. Sitagliptin has been linked to inflammation of the pancreas. Stop and call your doctor if you get severe, persistent stomach pain that may spread to the back.
• Have heart failure or are at risk of it. Report breathlessness, ankle swelling or sudden weight gain.
• Take insulin or a sulfonylurea (such as glimepiride). Combining them raises the risk of low blood sugar, and your doctor may lower their dose.
• Are allergic to sitagliptin, metformin or similar medicines. Serious reactions are possible.
• Take an ACE inhibitor. The chance of face or throat swelling (angioedema) may be higher.
• Have type 1 diabetes or ketoacidosis. This medicine is not for you.
• Are pregnant, planning pregnancy or breastfeeding. Check with your doctor first.

Possible Side Effects

Many people take this combination without problems. The most common effects are stomach-related and often settle in the first weeks, particularly when the tablet is taken with food.

Common:

• Nausea, vomiting
• Diarrhea or loose stools
• Stomach pain, bloating or gas
• Loss of appetite
• Metallic taste
• Headache
• Runny or stuffy nose, sore throat
• Low blood sugar, mainly when combined with insulin or a sulfonylurea

Less common:

• Constipation
• Swelling of the hands or feet
• Dizziness
• Joint or muscle pain
• Itching or skin rash
• Low vitamin B12 with long-term use

Frequently Asked Questions

1. Where can I buy sitagliptin and metformin hydrochloride tablets online?
Sitagliptin and metformin hydrochloride tablets can be purchased online through licensed pharmacies in India, subject to prescription requirements. Before purchasing, verify the product name, strengths, manufacturer, pack size, expiry date, and authenticity.

2. What is the price of sitagliptin and metformin hydrochloride tablets?
The price may vary depending on the brand, strength, manufacturer, pack size, pharmacy, and applicable offers or taxes. For the current price, contact the pharmacy or Steris Healthcare directly.

3. Can I order sitagliptin and metformin hydrochloride tablets online?
Yes, these tablets may be ordered online through a licensed pharmacy when a valid prescription is provided where required. The pharmacy may verify the prescription before processing the order.

4. Is sitagliptin and metformin hydrochloride tablets available from Steris Healthcare?
Availability depends on current stock and distribution. To confirm whether the required sitagliptin and metformin hydrochloride formulation is available from Steris Healthcare, contact the company directly with the required strengths and pack-size details.

5. What is sitagliptin and metformin hydrochloride tablets used for?
Sitagliptin and metformin hydrochloride tablets are used to help control blood glucose levels in adults with type 2 diabetes mellitus. Sitagliptin is a DPP-4 inhibitor, while metformin helps reduce glucose production by the liver and improves the body's response to insulin. The combination is generally used along with diet and exercise as prescribed.

6. What is the composition of sitagliptin and metformin hydrochloride tablets?
The tablets contain sitagliptin and metformin hydrochloride as active pharmaceutical ingredients. The exact strength of each ingredient depends on the specific formulation and should be confirmed on the product packaging or prescription.

7. Is a prescription required?
Yes. Sitagliptin and metformin hydrochloride combination tablets are prescription medicines and should be used under the supervision of a qualified healthcare professional. Do not start, stop, or change the dose without medical advice.

8. How should sitagliptin and metformin hydrochloride tablets be taken?
Take the tablets exactly as prescribed by your doctor. They are generally taken with meals to help reduce stomach-related side effects, but the exact dosing schedule depends on the formulation and individual treatment plan. Swallow extended-release tablets whole if prescribed; do not crush or chew them.

9. What should I know before buying sitagliptin and metformin hydrochloride tablets?
Before buying, verify the exact strengths, formulation, manufacturer, pack size, expiry date, and authenticity. Tell your doctor if you have kidney or liver problems, a history of pancreatitis, heart failure, or if you consume excessive alcohol. Metformin may rarely cause lactic acidosis, particularly in people with significant kidney impairment. Your doctor may monitor kidney function during treatment.

10. How can I order sitagliptin and metformin hydrochloride tablets online?
To order online, choose a licensed pharmacy, provide a valid prescription when requested, verify the product name, strengths, formulation, pack size, and manufacturer, and complete the pharmacy's ordering and payment process. For information about availability and ordering from Steris Healthcare, contact the company directly.