ST GLIPTIN 3D 1000

What Is ST GLIPTIN 3D 1000?

Type 2 diabetes is a long-term condition in which the body does not make or use insulin well enough to keep blood glucose in a healthy range. Most people need more than one medicine over time, because the condition tends to progress and different drugs address different causes. Fixed-dose combination tablets like ST GLIPTIN 3D 1000 bring three medicines into one tablet so that a person who has already been prescribed all three does not need to manage three separate strips.

Product Information

Detail	Information
Brand name	ST GLIPTIN 3D 1000
Composition	Sitagliptin [REVIEWER: confirm strength per label] + Metformin Hydrochloride 1000 mg + Pioglitazone [REVIEWER: confirm strength per label]
Dosage form	Tablet
Pack size	Pack of 15 tablets
Manufacturer / marketer	Steris Healthcare Pvt. Ltd.
Drug classes	DPP-4 inhibitor + biguanide + thiazolidinedione
Therapeutic area	Type 2 diabetes mellitus
Schedule	Schedule H – prescription only
Storage	Store in a cool, dry place away from light and moisture, out of reach of children [REVIEWER: confirm temperature statement against approved label]
MRP	[REVIEWER: insert approved MRP for pack of 15]
Target market	India

Clinical Indications

Condition	How the combination is used
Type 2 diabetes mellitus (adults)	As an adjunct to diet and exercise, when blood sugar is not adequately controlled and the doctor chooses a three-drug regimen
Patients already stable on the three separate components	As a convenient single-tablet alternative, at the doctor's discretion

The combination is not intended for type 1 diabetes or for diabetic ketoacidosis.

How ST GLIPTIN 3D 1000 Works

Each ingredient targets a different mechanism, which is why combinations can work better than a single drug alone.

Sitagliptin – the incretin supporter. After you eat, your gut releases hormones called incretins (GLP-1 and GIP) that tell the pancreas to release insulin and tell the liver to make less glucose. An enzyme called DPP-4 breaks these hormones down quickly. Sitagliptin blocks DPP-4, so incretin levels stay active longer. Because this effect depends on glucose levels, sitagliptin on its own has a low tendency to cause hypoglycaemia.

Metformin – the liver and gut regulator. Metformin mainly reduces the amount of glucose the liver releases into the blood and improves how muscle and fat tissue respond to insulin. It also slightly reduces glucose absorption from the gut. It does not push the pancreas to release extra insulin, which is why it does not usually cause low blood sugar when used alone.

Pioglitazone – the insulin sensitiser. Pioglitazone activates PPAR-gamma receptors, mainly in fat tissue, which helps muscle, fat and liver cells respond better to the insulin the body already makes. This effect builds over several weeks rather than appearing immediately.

Key Benefits of the Combination

• Three complementary mechanisms in one tablet, covering post-meal glucose, fasting glucose and insulin resistance
• Simpler routine: one tablet instead of three can help with adherence, which matters in a long-term condition
• Low intrinsic hypoglycaemia risk from these three components when used without insulin or a sulfonylurea, although the risk rises when combined with other glucose-lowering drugs
• Quality-assured manufacturing by a WHO-GMP and ISO-certified manufacturer
• Pack of 15 suited to a short supply cycle while the doctor reviews response and tolerance

Side Effects

Most people tolerate this combination, but each component has known effects.

Common (usually mild and often settle over time)

• Nausea, diarrhoea, stomach discomfort or loss of appetite (mainly from metformin)
• Headache, sore throat or runny nose
• Swelling of the feet or ankles (fluid retention, linked to pioglitazone)
• Weight gain (linked to pioglitazone)

Serious – contact your doctor promptly

• Shortness of breath, rapid weight gain, or marked swelling, which can signal heart failure
• Severe, persistent stomach pain with or without vomiting, which can signal pancreatitis (sitagliptin)
• Unusual muscle pain, weakness, fast breathing, drowsiness or feeling very unwell, which can signal lactic acidosis (rare, linked to metformin)
• Yellowing of the skin or eyes, dark urine or unusual tiredness, which can signal liver problems
• Severe or persistent joint pain
• Blistering skin reactions or signs of a serious allergic reaction
• Bone pain or a new fracture
• Changes in vision or blood in the urine

Substitutes and Related Options

Substitutes depend on which components and strengths your doctor wants. Do not switch products yourself.

Option	What it contains	Note
ST GLIPTIN 3D 1000 (Steris Healthcare)	Sitagliptin + Metformin 1000 mg + Pioglitazone	Single three-drug tablet
Other sitagliptin + metformin + pioglitazone fixed-dose tablets	Same three salts, different brand or strength	Confirm strengths match your prescription
Sitagliptin + metformin tablet, plus a separate pioglitazone tablet	Same drugs, two products	More tablets to manage
Sitagliptin, metformin and pioglitazone as three separate tablets	Same drugs, three products	Allows individual dose changes

Precautions and Warnings

Tell your doctor before starting if any of these apply to you:

• Heart failure or a history of it. Pioglitazone can cause fluid retention and is generally not used in advanced heart failure.
• Kidney disease. Metformin and sitagliptin both depend on kidney function, and the dose may need to change or the medicine may be unsuitable.
• Liver disease or raised liver enzymes.
• History of pancreatitis, bladder problems or blood in the urine, or fractures and bone weakness.
• Pregnancy, planning pregnancy or breastfeeding. Doctors usually switch to a different plan.
• Heavy alcohol use. It increases the risk of lactic acidosis and low blood sugar.
• Planned surgery, CT scans or X-rays using contrast dye. Metformin may need to be paused; your doctor will advise.
• Other glucose-lowering drugs, especially sulfonylureas such as gliclazide, or insulin, which raise the chance of hypoglycaemia.
• Vitamin B12. Long-term metformin use can lower B12; your doctor may check it periodically.

Why Choose ST GLIPTIN 3D 1000 from Steris Healthcare? 

Steris Healthcare Pvt. Ltd. manufactures pharmaceutical and nutraceutical products in India under WHO-GMP and ISO-certified quality systems. For a long-term medicine like a diabetes combination tablet, consistent quality and reliable supply matter as much as the molecule itself.

• Manufacturer-direct information: product details come from Steris Healthcare's own portfolio
• Clear pack size: pack of 15 tablets
• Prescription-compliant supply: dispensed against a valid prescription
• Support for pharmacies and distributors: bulk and B2B enquiries are handled through the Steris contact numbers below

How to Check Price and Order

1. Keep a valid prescription ready that names a sitagliptin, metformin and pioglitazone combination at the strengths your doctor chose.
2. Visit sterisonline.com and search for ST GLIPTIN 3D 1000, then use Check Price on the product page.
3. Or contact Steris Healthcare by phone or email using the details at the bottom of this page to ask about price, availability and delivery.
4. Pharmacies and distributors: ask about bulk supply and trade terms through the same contacts.
5. At delivery, check the brand name, strength, batch number and expiry date against your prescription.

Lifestyle Tips While Using Diabetes Medicines

A tablet works best alongside daily habits. Choose a balanced plate with plenty of vegetables, pulses and whole grains, and keep refined sugar and sugary drinks low. Aim for regular physical activity as your doctor allows, check your glucose as advised, look after your feet, and keep up with eye, kidney and heart check-ups. If you feel dizzy, shaky or sweaty, check your glucose and follow your doctor's hypoglycaemia plan.

Conclusion

ST GLIPTIN 3D 1000 brings sitagliptin, metformin 1000 mg and pioglitazone together in one tablet for adults with type 2 diabetes whose doctor has chosen a three-drug approach. Its strength lies in combining three different mechanisms, but it also carries real cautions, particularly around the heart, kidneys, liver and hypoglycaemia when other drugs are added. Use it only as prescribed, keep your follow-up tests, and report warning symptoms early. To check the price or ask about availability, use sterisonline.com or the Steris Healthcare contacts below.

Frequently Asked Questions 

1. Can you take sitagliptin and pioglitazone together?

Yes, doctors do prescribe sitagliptin and pioglitazone together for type 2 diabetes, because they work in different ways: sitagliptin prolongs incretin activity while pioglitazone improves insulin sensitivity. ST GLIPTIN 3D 1000 adds metformin as a third component. The combination should only be used on a doctor's advice, with attention to heart, liver and kidney health.

2. Should I take metformin 1000 mg?

Whether metformin 1000 mg suits you is a decision for your doctor. It depends on your blood sugar, kidney function and how well you tolerate metformin, since it is usually started low and increased gradually to limit stomach upset. ST GLIPTIN 3D 1000 contains 1000 mg of metformin hydrochloride per tablet, so it is meant for people whose doctor has already settled on that metformin amount. Do not adjust the dose yourself.

3. How does pioglitazone metformin work?

Pioglitazone and metformin both reduce insulin resistance but in different ways. Pioglitazone makes muscle, fat and liver cells respond better to insulin, while metformin lowers the amount of glucose released by the liver and improves insulin response in tissues. Used together, they tackle high blood sugar from two directions without directly forcing the pancreas to release more insulin.

4. How do sitagliptin, metformin and pioglitazone work together in ST GLIPTIN 3D 1000?

Sitagliptin keeps incretin hormones active so insulin is released appropriately after meals and glucagon is reduced. Metformin reduces glucose production by the liver. Pioglitazone improves how cells use insulin. Combining the three covers post-meal glucose, fasting glucose and insulin resistance in one tablet.

5. Can I use gliclazide and metformin together?

Gliclazide and metformin are commonly prescribed together, because gliclazide stimulates insulin release and metformin lowers liver glucose output. The main concern is low blood sugar from gliclazide. If you already take gliclazide and your doctor prescribes ST GLIPTIN 3D 1000, tell them, because adding more glucose-lowering drugs may call for a dose review of the gliclazide to reduce hypoglycaemia risk.

6. What is ST GLIPTIN 3D 1000 used for?

It is used in adults with type 2 diabetes mellitus, alongside diet and exercise, when a doctor decides that a combination of sitagliptin, metformin and pioglitazone is appropriate. It is not for type 1 diabetes or diabetic ketoacidosis.

7. What is the composition of ST GLIPTIN 3D 1000?

Each tablet contains sitagliptin, metformin hydrochloride 1000 mg and pioglitazone. [REVIEWER: insert sitagliptin and pioglitazone strengths from the approved label.] It is a tablet in a pack of 15.

8. Is a prescription required for ST GLIPTIN 3D 1000?

Yes. It is a Schedule H medicine and should be taken only on the prescription of a registered medical practitioner.

9. How should I take ST GLIPTIN 3D 1000?

Take it exactly as your doctor prescribed, swallowed whole with water, usually with or after a meal to reduce stomach upset. Take it at the same time each day and do not change the dose on your own. [REVIEWER: confirm timing against the approved label.]

10. What are the common side effects of ST GLIPTIN 3D 1000?

Common effects include nausea, diarrhoea, stomach discomfort, headache, swelling of the ankles or feet and weight gain. Many digestive effects ease with time. Report persistent or troublesome symptoms to your doctor.

11. What serious side effects should I watch for?

Seek medical help for shortness of breath or rapid swelling, severe stomach pain, yellowing of the skin or eyes, unusual muscle pain with fast breathing and drowsiness, severe joint pain, a serious skin or allergic reaction, bone pain or fracture, or blood in the urine.

12. Can ST GLIPTIN 3D 1000 cause low blood sugar?

The three components alone have a low tendency to cause hypoglycaemia, but the risk rises if you also take insulin or a sulfonylurea such as gliclazide, skip meals, drink alcohol or exercise heavily. Know the symptoms (shakiness, sweating, dizziness, hunger, confusion) and follow your doctor's plan.

13. Who should not take ST GLIPTIN 3D 1000?

People with type 1 diabetes or ketoacidosis, heart failure, severe kidney impairment, active liver disease, or allergy to any ingredient should not use it unless the doctor has decided otherwise. Tell your doctor if you are pregnant, planning pregnancy or breastfeeding.

14. Is ST GLIPTIN 3D 1000 safe for the heart and kidneys?

Pioglitazone can cause fluid retention and is generally avoided in heart failure, and metformin and sitagliptin depend on kidney function. Your doctor will check your heart and kidney status before and during treatment. Report swelling, breathlessness or reduced urine output promptly.

15. Can I drink alcohol while taking ST GLIPTIN 3D 1000?

Heavy or binge drinking is best avoided, as alcohol increases the risk of lactic acidosis with metformin and can cause low blood sugar. Ask your doctor what is safe for you.

16. What is the price of ST GLIPTIN 3D 1000 in India?

The price depends on the approved MRP for the pack of 15 tablets. [REVIEWER: insert MRP.] Use Check Price on sterisonline.com or contact Steris Healthcare for current price and availability.

17. Where can I buy ST GLIPTIN 3D 1000 online?

Check price and availability on sterisonline.com or contact Steris Healthcare Pvt. Ltd. on +91 8824175417 or +91 9982524671, or by email. A valid prescription is required.

18. Is ST GLIPTIN 3D 1000 available from Steris Healthcare for pharmacies and distributors?

Yes, trade and bulk enquiries can be made through the Steris Healthcare contacts below. Prescription-medicine supply follows applicable regulations.

19. What should I do if I miss a dose?

Take it as soon as you remember, unless the next dose is nearly due. Do not take a double dose to catch up.

20. How should I store ST GLIPTIN 3D 1000?

Keep it in a cool, dry place away from light and moisture, and out of reach of children. [REVIEWER: confirm against the approved label.]