SILODOSIA M 25

SILODOSIA M 25 is a specialized oral medication combining two active ingredients: Mirabegron 25mg and Silodosin 8mg. This combination tablet is formulated to provide an effective therapeutic approach for men experiencing lower urinary tract symptoms associated with benign prostatic hyperplasia (BPH) coupled with overactive bladder (OAB). Mirabegron 25mg works by relaxing the bladder muscles to reduce urgency and frequency, while Silodosin 8mg relaxes the muscles in the prostate and bladder neck to improve urine flow and reduce urinary retention. Together, these agents provide comprehensive symptom relief with improved bladder control and reduced discomfort. This medication is especially beneficial for patients struggling with the complex symptoms of BPH aggravated by OAB.

What is SILODOSIA M 25?

SILODOSIA M 25 is a combination tablet containing Mirabegron 25mg and Silodosin 8mg, designed to address urinary system disorders. Mirabegron acts on beta-3 adrenergic receptors in the bladder to relax detrusor muscles, reducing the urgency and frequency of urination. Silodosin is an alpha-1 adrenergic receptor antagonist that relaxes muscles in the prostate and bladder neck, easing urine passage. The combination targets both bladder overactivity and prostate enlargement to offer enhanced symptom management.

Uses of SILODOSIA M 25:

• Management of symptoms related to benign prostatic hyperplasia (BPH), such as difficulty in urination, weak urine stream, and straining.

• Relief from overactive bladder (OAB) symptoms, including frequent urination, urgency, nocturia (nighttime urination), and urinary incontinence.

• Improvement of urinary flow by relaxing prostate and bladder muscles to ease discomfort and reduce obstruction.

• Reduction in episodes of urinary urgency and urge incontinence associated with OAB.

• Enhancing the quality of life for patients suffering from BPH complicated by OAB.
  All these benefits are achieved as SILODOSIA M 25 combines the efficacy of Mirabegron 25mg and Silodosin 8mg to manage symptoms of benign prostatic hyperplasia (BPH) complicated by overactive bladder (OAB).

Side Effects of SILODOSIA M 25:

• Dizziness and lightheadedness, especially upon standing suddenly.

• Nasal congestion or runny nose.

• Headache and dry mouth.

• Constipation and nausea.

• Abnormal ejaculation, such as retrograde ejaculation.

• Increased heart rate (tachycardia) and palpitations.

• Urinary tract infections in some cases.

• Orthostatic hypotension (drop in blood pressure on standing).
  Most side effects are mild and tend to improve with continued use; however, patients experiencing severe or persistent symptoms should consult their healthcare provider promptly.

Precautions Before Using SILODOSIA M 25:

• Inform your doctor if you have liver or kidney impairment, cardiovascular diseases, or a history of low blood pressure. Dose adjustments may be necessary.

• Avoid sudden changes in posture to prevent dizziness or fainting episodes.

• Not recommended for use in women or children.

• Inform your physician if you are about to undergo cataract surgery, as Silodosin may cause complications during the procedure.

• If you experience symptoms such as severe headaches, chest pain, or sudden vision changes, seek medical attention immediately.

• Avoid driving or operating heavy machinery if you feel dizzy or less alert after taking the medication.

• Maintain regular follow-up appointments for monitoring blood pressure and symptom progress.

Drug Interactions – What Drugs Interact with SILODOSIA M 25?

• Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole) and inducers may alter the effectiveness of Mirabegron and Silodosin.

• Antipsychotic drugs such as thioridazine, and antiarrhythmic medications like flecainide and propafenone, can interact and potentially increase side effects.

• Blood thinners such as dabigatran may interact, requiring monitoring.

• Drugs used to treat depression (e.g., desipramine, imipramine) and HIV (ritonavir) may affect SILODOSIA M 25 efficacy.

• Combination with other alpha-blockers (like doxazosin, prazosin) can increase the risk of low blood pressure.

• Use caution with medications that cause urinary retention, like amitriptyline, as combined use may raise this risk.

• Alcohol interactions are not well established but should be avoided or discussed with a healthcare professional.
  Inform your healthcare provider about all medications and supplements you are taking to avoid potentially harmful interactions.

SILODOSIA M 25, combining Mirabegron 25mg and Silodosin 8mg, offers an effective pharmaceutical solution to handle complex urinary symptoms by targeting both prostate and bladder muscle relaxation. This helps men better manage symptoms of benign prostatic hyperplasia (BPH) complicated by overactive bladder (OAB), improving comfort and urinary function under medical supervision.