If you have CKD or dialysis and need a potent non-calcium phosphate binder to control high blood phosphorus levels, Sevelamer 400 mg is A phosphate-binding medication used to manage elevated blood phosphate levels (hyperphosphatemia) in patients with severe kidney disease. Controlling serum phosphate is not just about a number on a blood test – it directly protects your heart, bones and blood vessels from the serious long-term complications of hyperphosphataemia.

What Is Sevelamer 400 mg?

Sevelamer 400 mg is an oral phosphate binder containing sevelamer hydrochloride as the active ingredient. It is a non-absorbed, non-calcium, non-metal polymer that binds dietary phosphate in the gastrointestinal tract — preventing it from entering the bloodstream.

Indicated for:

• Control of hyperphosphataemia (high blood phosphate) in adult patients with chronic kidney disease (CKD)
• Patients on haemodialysis or peritoneal dialysis
• CKD patients not yet on dialysis with serum phosphate levels above target range
• Patients requiring a calcium-free phosphate binder due to hypercalcaemia risk

How Does Sevelamer 400 mg Work?

In healthy kidneys, excess phosphate from food is filtered out through urine. In CKD and dialysis patients, this filtering capacity is severely reduced — causing phosphate to accumulate in the blood (hyperphosphataemia).

Sevelamer 400 mg works through a purely mechanical, non-systemic binding process:

• Binds dietary phosphate in the gut before it is absorbed into the bloodstream
• Forms an insoluble complex with phosphate that is safely excreted in stools
• No calcium added to the body — critical for patients already at risk of vascular calcification
• Also binds bile acids — providing an additional benefit of lowering LDL cholesterol levels
• Not absorbed systemically — acts entirely within the gastrointestinal tract

This localised action makes Sevelamer 400 mg one of the safest long-term phosphate management options for dialysis patients, with no risk of calcium overload or aluminium toxicity associated with older binder types.

Dosage & How to Take Sevelamer 400 mg

Recommended Adult Dose:

• 800–1600 mg with each main meal (typically 2–4 tablets of 400 mg per meal)
• Starting dose is guided by current serum phosphate levels — your nephrologist will advise
• Dose is adjusted every 2–4 weeks based on blood phosphate test results
• Take tablets with meals — not before or after — to bind phosphate at the point of digestion

Important Instructions:

• Swallow tablets whole — do not crush, chew, or split, as the polymer matrix must remain intact to bind phosphate effectively
• Never take on an empty stomach — Sevelamer only works when dietary phosphate is present in the gut
• Maintain your prescribed low-phosphate diet alongside medication for best results
• Take other medications (especially fluoroquinolone antibiotics, levothyroxine, or ciclosporin) at least 1 hour before or 3 hours after Sevelamer to avoid interaction

Key Benefits of Sevelamer 400 mg

Who Should Use Sevelamer 400 mg?

Sevelamer 400 mg is prescribed for adults who:

• Have CKD Stage 3–5 with elevated serum phosphate levels
• Are on haemodialysis or peritoneal dialysis requiring phosphate control
• Cannot tolerate calcium-based binders due to elevated calcium or vascular calcification risk
• Need a phosphate binder that also helps manage LDL cholesterol
• Are transitioning from aluminium-based or calcium-based binders under medical supervision

Do not use if you:

• Have bowel obstruction or a history of major gastrointestinal surgery
• Have hypophosphataemia (abnormally low phosphate levels)
• Are allergic to sevelamer hydrochloride or any excipient in the formulation
• Are under 18 years of age — paediatric dosing requires specialist guidance

Common Side Effects — What to Expect

Sevelamer 400 mg is generally well tolerated given its non-systemic action. Reported side effects are mainly gastrointestinal:

• Nausea
• Vomiting
• Abdominal pain or discomfort
• Constipation or diarrhoea (usually mild)
• Dyspepsia (indigestion)

Most GI side effects improve as the body adjusts to the medication. Taking Sevelamer consistently with meals — never on an empty stomach — significantly reduces the likelihood of stomach upset.

FAQs About Sevelamer 400 mg

Q: What is Sevelamer 400 mg used for?

Sevelamer 400 mg is used to control high phosphate levels in the blood (hyperphosphataemia) in adults with chronic kidney disease, including those on haemodialysis or peritoneal dialysis. By binding dietary phosphate in the gut before it is absorbed, it helps protect the heart, bones, and blood vessels from the damaging effects of elevated phosphate.

Q: How and when should I take Sevelamer 400 mg?

Sevelamer 400 mg tablets must be taken with meals — typically 2 to 4 tablets per main meal, depending on your prescribed dose. Swallow tablets whole with water during eating. Never take them on an empty stomach, as the medication only works when food-sourced phosphate is present in the digestive tract.

Q: What is the difference between Sevelamer 400 mg and Sevelamer 800 mg?

Both strengths contain the same active ingredient — sevelamer hydrochloride. Sevelamer 800 mg tablets simply allow patients requiring higher doses to take fewer tablets per meal, improving convenience. Your nephrologist will determine the most appropriate strength based on your individual phosphate levels and meal habits.

Q: Can Sevelamer 400 mg affect other medications I take?

Yes. Sevelamer can reduce the absorption of certain medications if taken at the same time. Drugs particularly affected include fluoroquinolone antibiotics, levothyroxine, and ciclosporin. As a general rule, take all other medications at least 1 hour before or 3 hours after your Sevelamer dose to avoid interference.

Q: Does Sevelamer 400 mg lower cholesterol?

Yes, as an additional benefit. Sevelamer binds bile acids in the gut alongside phosphate, which leads to a modest but clinically meaningful reduction in LDL (bad) cholesterol. This cardiovascular benefit is particularly valuable for CKD and dialysis patients who are already at elevated risk of heart disease.

Q: Why is a calcium-free phosphate binder like Sevelamer preferred for dialysis patients?

Dialysis patients are at high risk of vascular and soft tissue calcification — a condition worsened by excess calcium intake. Calcium-based phosphate binders add calcium to the body with every dose. Sevelamer contains no calcium, making it the preferred choice for patients with elevated calcium levels, vascular calcification, or those at high cardiovascular risk.

Q: How long does it take for Sevelamer 400 mg to lower phosphate levels?

Sevelamer begins binding dietary phosphate from your very first dose, but measurable reductions in serum phosphate levels are typically assessed after 2 to 4 weeks of consistent use. Your nephrologist will monitor your blood phosphate at regular intervals and adjust your dose accordingly.

Q: Where can I buy Sevelamer 400 mg online?

You can order genuine Sevelamer 400 mg tablets safely and securely from this product page. We supply pharmacy-grade medication sourced from licensed manufacturers, with fast dispatch, discreet packaging, and a fully encrypted secure checkout on every order.

Product Information

Brand name: SAVELINER 400 (STERIS HEALTHCARE PVT LTD)

Composition Name: Sevelamer 400 mg 

Pack size: Strip of 10 tablets

Marketed By: Steris Healthcare Pvt Ltd

Regulatory standard: WHO-GMP certified

Schedule: Valid Prescription Required (prescription only) please create in this manner.