RIZONITIME 5

RIZONITIME 5 is a fast-acting formulation of Rizatriptan Benzoate 5 mg, designed as an orally disintegrating tablet (ODT) to provide convenient and effective relief from acute migraine attacks. Manufactured with high-quality standards, this formulation dissolves quickly on the tongue, making it suitable for patients who struggle with swallowing tablets during intense migraine phases accompanied by nausea or vomiting.

Rizatriptan belongs to the triptan class of medicines, which are known for their targeted mechanism of action on serotonin (5-HT1B/1D) receptors. By narrowing dilated blood vessels in the brain and blocking pain pathways, RIZONITIME 5 offers rapid relief and helps patients return to normal activities sooner.

This product has been curated keeping in mind the specific healthcare needs of the Indian population, ensuring reliability, safety, and clinical effectiveness.

What is RIZONITIME 5 Used For? (Uses)

RIZONITIME 5 is indicated for:

• Acute treatment of migraine attacks, with or without aura

• Relief from migraine-associated symptoms such as:

  • Throbbing head pain

  • Nausea or vomiting

  • Sensitivity to sound (phonophobia)

  • Sensitivity to light (photophobia)

• Rapid onset relief where swallowing tablets becomes difficult

• Patients needing portable and easy-to-take migraine medication

It is not intended for prevention of migraines and should be taken only when an attack begins.

How RIZONITIME 5 Works – Mechanism of Action

Rizatriptan is a selective 5-HT1B/1D receptor agonist.
The key benefits of its mechanism include:

1. Constriction of cranial blood vessels, reducing the vascular dilation that triggers migraine pain.

2. Blocking release of neuropeptides, which are responsible for inflammation and pain around brain tissues.

3. Interrupting pain signals within the central nervous system.

Due to its ODT format, RIZONITIME 5 is absorbed efficiently through the oral mucosa, which can result in earlier onset of action compared to traditional tablets.

Key Benefits of RIZONITIME 5

1. Fast-Acting Relief

The orally disintegrating formulation offers quick absorption, allowing many patients to feel relief sooner.

2. Suitable for Patients with Nausea

Migraine patients often struggle to swallow tablets. RIZONITIME 5 solves this problem by dissolving instantly on the tongue.

3. Portable & Convenient

No need for water. Patients can carry RIZONITIME 5 anywhere, making it ideal for sudden migraine episodes at work, travel, or outdoors.

4. Targeted Mechanism

The targeted effect on serotonin receptors minimizes unnecessary systemic exposure, enhancing effectiveness.

5. Helps Restore Function

By reducing pain and associated symptoms quickly, patients can resume daily routines faster.

Before Using RIZONITIME 5

1. Consult Your Healthcare Provider

This medication is available only when recommended by a doctor. A diagnosis of migraine is essential to ensure safe use.

2. Medical History Considerations

Tell your doctor if you have or have ever had:

• Heart disease

• Irregular heartbeat

• High blood pressure

• Stroke or transient ischemic attacks

• Blood circulation disorders

• High cholesterol

• Diabetes

• Liver or kidney issues

Patients with a history of cardiovascular problems must use RIZONITIME 5 with extreme caution.

Allergies

Avoid RIZONITIME 5 if you are allergic to:

• Rizatriptan Benzoate

• Any triptan medication

• Ingredients in the orally disintegrating tablet

Symptoms of allergy may include:

• Rash

• Swelling of lips or face

• Difficulty breathing

• Severe dizziness

Seek emergency help in such cases.

Pediatric Use

• RIZONITIME 5 may be used in children above 6 years, but the dosage must be strictly guided by a pediatric neurologist.

• The ODT format is particularly beneficial for children who may struggle with swallowing.

Geriatric Use

• Patients above 65 years may have reduced organ function and increased cardiovascular risks.

• A lower starting dose or additional monitoring may be required.

• Use only after medical assessment of heart health.

Use During Breastfeeding

• Rizatriptan may pass into breast milk.

• Doctors may advise expressing and discarding breast milk for up to 24 hours after taking a dose.

• Always discuss with the treating physician.

Drug Interactions

RIZONITIME 5 may interact with:

1. Other Migraine Medicines

• Ergotamine

• Dihydroergotamine

• Other triptans

A minimum 24-hour gap is required between these medicines and Rizatriptan.

2. Antidepressants

• SSRIs

• SNRIs

• MAO inhibitors

Risk of serotonin syndrome increases.

3. Beta-Blockers (especially Propranolol)

Propranolol increases the concentration of Rizatriptan. Dose adjustments may be needed.

4. Herbal Products

St. John’s Wort may alter drug levels. Always inform your doctor about all supplements.

Other Interactions

• Alcohol may worsen migraine symptoms and reduce drug effectiveness.

• Smoking may increase vascular complications in migraine patients.

• High-caffeine beverages can intensify migraines in some people.

Other Medical Problems

Tell your doctor if you have:

• Heart disease

• Angina

• Peripheral vascular disease

• Uncontrolled hypertension

• Severe liver impairment

• Kidney problems

• Atypical or hemiplegic migraines

• Basilar migraines

Rizatriptan is not recommended for these conditions.

Proper Use of RIZONITIME 5

How to Take the Orally Disintegrating Tablet

1. Make sure your hands are dry.

2. Peel the blister pack — do not push the tablet through the foil.

3. Place the tablet on your tongue.

4. It dissolves within seconds without water.

5. Take the dose as soon as you feel migraine symptoms starting.

Important Guidelines

• Do not take it for routine headache types such as tension headache or cluster headache.

• If your migraine does not improve with the first dose, consult your doctor before taking another dose.

• Never exceed the daily maximum dosage.

Dosage Information

Adult Dose

• Usual dose: 5 mg at onset of migraine

• A second dose may be taken after 2 hours, if needed

• Maximum per day: 15 mg unless otherwise directed

Pediatric Dose

• Determined strictly by the treating physician

• Generally lower than adult doses

Geriatric Dose

• Usually initiated at lower strength due to increased sensitivity

Missed Dose

• This medicine is taken only when migraine symptoms occur, so there is no routine dosing schedule.

• If you miss taking it at the onset, take it as soon as symptoms become noticeable.

Storage Instructions

• Store in a cool, dry place below 25°C

• Keep blister packs intact until use

• Keep away from children

• Do not use damaged or open blister packs

Precautions

• Do not drive or operate machinery after taking the tablet if you feel dizzy or drowsy

• Avoid overusing migraine medications to prevent medication-overuse headache

• Inform your doctor if migraines become more frequent or severe

• Avoid taking multiple migraine medicines on the same day unless prescribed

• Stay hydrated and avoid known migraine triggers

Possible Side Effects

Side effects are generally mild and temporary. Common reactions include:

Common Side Effects

• Dizziness

• Sleepiness

• Fatigue

• Dry mouth

• Tingling sensation

• Warmth or flushing

Less Common but Serious

• Tightness in chest or throat

• Irregular heartbeat

• Severe stomach pain

• Vision changes

Seek immediate medical care if these occur.

Conclusion

RIZONITIME 5 (Rizatriptan Benzoate Orally Disintegrating Tablets 5 mg) is a trusted, fast-acting, and convenient treatment option for acute migraine attacks. Designed for comfort, portability, and rapid action, it helps patients regain control over their day even during sudden migraine episodes.