REVOSTATIN EZ 40

Revostatin EZ 40 is a fixed-dose combination of two cholesterol-lowering medicines in one tablet. It sits at the top of the Revostatin EZ range (10, 20 and 40), where the number refers to the rosuvastatin strength. Ezetimibe stays at 10 mg, the standard daily dose.

The two ingredients work at different points in the cholesterol cycle:

• Rosuvastatin acts in the liver. It blocks HMG-CoA reductase, the enzyme that makes cholesterol. The liver then removes more LDL from the blood.
• Ezetimibe acts in the small intestine. It blocks the NPC1L1 transporter, which cuts the amount of dietary and bile cholesterol that gets absorbed.

Using both lowers LDL further than raising a statin dose alone usually does. Ezetimibe typically adds roughly 15 to 20% extra LDL reduction on top of a statin.

Where does the 40 mg strength fit? Rosuvastatin 40 mg is reserved for patients who still have LDL above target on 20 mg, and who have been judged suitable for it. Doctors weigh kidney function, thyroid status, age, ethnicity, other medicines and muscle-related history before using it. Many patients reach their goal on the 10 or 20 strengths, and the 40 version is the exception, not the rule.

It is manufactured by Steris Healthcare Pvt. Ltd., Jaipur, a WHO-GMP and ISO certified pharmaceutical company.

Product Information

Why Is Revostatin EZ 40 Important?

Some people carry cholesterol levels or risk profiles where a mild or moderate treatment will not do the job.

1. Very high risk needs very low LDL. Patients with a previous heart attack or stroke, multiple blocked arteries, diabetes with organ damage, or familial hypercholesterolaemia (inherited very high cholesterol) are often given stricter LDL goals than the general population.

2. Inherited cholesterol disorders are under-recognised. In familial hypercholesterolaemia, LDL is high from birth and artery damage can begin in young adulthood. Intensive combination therapy is often required, usually under a cardiologist or lipid specialist.

3. India's early heart disease burden. Coronary artery disease tends to occur about a decade earlier in South Asians. Combined with a common pattern of high triglycerides and small dense LDL particles, this makes tight lipid control especially valuable.

4. Evidence supports lower LDL. Trials such as IMPROVE-IT showed that adding ezetimibe to a statin lowered cardiovascular events in high-risk patients. In general, the lower the LDL achieved safely, the greater the protection.

5. One tablet supports consistency. Replacing two separate tablets with one can make long-term adherence easier, and adherence is what protects your arteries.

An important safety point for Indian patients: Blood levels of rosuvastatin are noticeably higher in people of Asian ancestry. Because of this, the 40 mg strength needs particular care, and labelling in several countries restricts or advises against it in Asian patients. Your doctor will decide if this strength is appropriate for you. Never move up to the 40 mg strength on your own.

Key Benefits 

• Intensive LDL lowering. The highest statin strength plus ezetimibe supports the greatest LDL reduction in this range.
• Two-way action. It reduces both cholesterol production in the liver and absorption in the gut.
• Helps very-high-risk patients approach strict targets. This includes people with established heart disease, prior stroke or familial hypercholesterolaemia.
• Supports long-term artery protection. Sustained low LDL reduces plaque build-up over time.
• One tablet instead of two. A simpler routine once the doses are established.
• Trusted manufacturing. Produced by Steris Healthcare under WHO-GMP standards.

Uses of Revostatin EZ 40

Your doctor may consider this tablet:

• For primary hypercholesterolaemia or mixed hyperlipidaemia that has not reached target on lower strengths
• For patients with very high cardiovascular risk who need intensive LDL reduction
• For selected patients with familial hypercholesterolaemia, under specialist guidance
• As a convenient replacement for taking rosuvastatin 40 mg and ezetimibe 10 mg as separate tablets, once the doses are established

A lipid profile, liver function test and kidney function test are normally checked before and during treatment.

Precautions: What to Know Before Taking 

Because this is the highest strength, precautions matter more here than with the lower versions.

Do not take this medicine if you:

• Are pregnant, planning pregnancy or breastfeeding
• Have active liver disease or unexplained, persistently raised liver enzymes
• Are allergic to rosuvastatin, ezetimibe or any ingredient in the tablet
• Are taking cyclosporine

This strength is generally not suitable, or needs special specialist judgement, if you:

• Have moderate to severe kidney impairment
• Have an underactive thyroid that is not controlled
• Have a personal or family history of muscle disorders
• Have had muscle problems with another statin or fibrate
• Drink alcohol heavily
• Are of Asian ancestry, because rosuvastatin exposure is higher
• Take fibrates (especially gemfibrozil) or other interacting medicines

Side Effects 

Many people take this combination without trouble. Side effects are usually mild, but the chance of some effects, especially muscle-related ones and protein in the urine, rises with higher statin strengths.

Common:

• Headache
• Muscle aches or pain (myalgia)
• Abdominal pain
• Diarrhoea or constipation
• Nausea
• Tiredness

Less common:

• Dizziness
• Joint pain
• Skin rash or itching
• Raised liver enzymes on a blood test
• Slight rise in blood sugar
• Protein in the urine (more frequent at higher doses)

Frequently Asked Questions

Where can I buy Rosuvastatin and Ezetimibe Tablets online?
You can buy Rosuvastatin and Ezetimibe Tablets online through a licensed pharmacy or authorized pharmaceutical supplier, subject to prescription requirements and product availability.

What is the price of Rosuvastatin and Ezetimibe Tablets?
The price may vary depending on the rosuvastatin and ezetimibe strengths, brand, pack size, seller, and applicable charges. Check the current product listing for the latest price.

Can I order Rosuvastatin and Ezetimibe Tablets online?
Yes, Rosuvastatin and Ezetimibe Tablets can generally be ordered online through an authorized pharmacy or pharmaceutical supplier when available. A valid prescription may be required.

Is Rosuvastatin and Ezetimibe Tablets available from Steris Healthcare?
Availability of Rosuvastatin and Ezetimibe Tablets from Steris Healthcare depends on the current product range and stock. Check the relevant product listing or contact Steris Healthcare for current availability.

What are Rosuvastatin and Ezetimibe Tablets used for?
Rosuvastatin and Ezetimibe Tablets are used to help lower elevated cholesterol levels, particularly LDL cholesterol. Rosuvastatin reduces cholesterol production in the liver, while ezetimibe reduces cholesterol absorption in the intestine.

What is the composition of Rosuvastatin and Ezetimibe Tablets?
Rosuvastatin and Ezetimibe Tablets contain rosuvastatin and ezetimibe as active ingredients. The exact strength of each ingredient depends on the specific formulation and should be verified on the product packaging.

Is a prescription required?
Yes, Rosuvastatin and Ezetimibe Tablets are prescription medicines and should be used under the supervision of a qualified healthcare professional.

How should Rosuvastatin and Ezetimibe Tablets be taken?
Take Rosuvastatin and Ezetimibe Tablets exactly as prescribed by your doctor. They are generally taken orally once daily, with or without food. Follow the prescribed dose and do not change or stop treatment without medical advice.

What should I know before buying Rosuvastatin and Ezetimibe Tablets?
Before buying, verify the strengths of rosuvastatin and ezetimibe, dosage form, pack size, manufacturer or marketer, expiry date, and storage instructions. Inform your doctor about liver or kidney problems, muscle-related conditions, pregnancy, allergies, and all medicines or supplements you are taking.

How can I order Rosuvastatin and Ezetimibe Tablets online?
To order Rosuvastatin and Ezetimibe Tablets online, select the required strength and pack size from an authorized pharmacy or supplier, provide a valid prescription if required, and complete the applicable payment and delivery process.