TELMISTRUM TRIO 6.25

TELMISTRUM TRIO 6.25 combines Telmisartan (40mg), Cilnidipine (10mg), and Chlorthalidone (6.25mg) into a single daily fixed-dose triple combination tablet. Manufactured by Steris Healthcare Pvt. Ltd. in 10-tablet strips, it provides comprehensive blood pressure control for patients with resistant or difficult-to-manage hypertension.

Why Choose TELMISTRUM TRIO 6.25?

Managing essential hypertension often requires targeting multiple physiological pathways simultaneously. When monotherapy or dual-drug combinations fail to reach target blood pressure goals, triple therapy with telmisartan 40 mg, cilnidipine 10 mg and chlorthalidone 6.25 mg provides powerful, complementary control.

• Targeted Synergy: Unites three distinct classes of anti-hypertensive agents—an ARB, a dual L/N-type calcium channel blocker, and a long-acting thiazide-like diuretic.

• Single-Pill Convenience: Replaces three individual prescription medications with one pill, simplifying daily regimens and improving long-term adherence.

• Organ Protection: Supports cardiovascular health while protecting renal structures and vascular endothelium from long-term pressure damage.

• Balanced Tolerability: Formulated with low-dose Chlorthalidone (6.25mg) and N-type calcium-blocking Cilnidipine (10mg) to minimize common side effects like ankle swelling, reflex tachycardia, and severe electrolyte depletion.

Mechanism of Action

1. Telmisartan (40mg) – Angiotensin II Receptor Blocker (ARB)

Telmisartan selectively displaces Angiotensin II from its $AT_1$ receptor binding sites in vascular smooth muscle and adrenal glands. By blocking $AT_1$ receptors, it stops hormone-induced vasoconstriction, decreases total peripheral resistance, and inhibits aldosterone release (reducing fluid retention). Telmisartan features an extensive 24-hour elimination half-life, ensuring smooth nocturnal and early-morning blood pressure control.

2. Cilnidipine (10mg) – Dual L-Type and N-Type Calcium Channel Blocker (CCB)

Unlike traditional calcium channel blockers like Amlodipine (which primarily block L-type channels), Cilnidipine inhibits both L-type and N-type voltage-gated calcium channels:

• L-type Channel Blockade: Relaxes vascular smooth muscle cells in peripheral arteries, producing direct vasodilation and lower systemic pressure.

• N-type Channel Blockade: Suppresses sympathetic nerve terminals, controlling norepinephrine release. This prevents reflex tachycardia (racing heart) and dilates efferent renal arterioles, significantly reducing intraglomerular pressure and lower-limb ankle edema.

3. Chlorthalidone (6.25mg) – Thiazide-like Diuretic

Chlorthalidone acts on the distal convoluted tubule of the nephron to inhibit sodium ($\text{Na}^+$) and chloride ($\text{Cl}^-$) reabsorption. It increases sodium and water excretion, reducing extracellular fluid and plasma volume. Chlorthalidone offers a much longer duration of action (up to 48–72 hours) and higher potency than hydrochlorothiazide (HCTZ), keeping blood pressure stable with a low 6.25mg dose.

Indications & Dosage Guidelines

Approved Clinical Indications

• Management of Stage 2 Essential Hypertension in adult patients.

• Treatment of resistant hypertension uncontrolled by dual anti-hypertensive combination therapies.

• Patients who develop peripheral edema or reflex tachycardia on standard L-type calcium channel blocker regimens.

How to Take

• Dosage: As directed by your treating physician (typically 1 tablet once daily).

• Administration: Swallow the tablet whole with a full glass of water. Do not crush, break, or chew it.

• Food Effect: Can be taken with or without food, though taking it at the same time each day (preferably in the morning) yields the best results.

• Diuretic Timing: Taking your morning dose helps prevent nighttime trips to the bathroom.

Safety Profile & Precautions

While TELMISTRUM TRIO 6.25 is generally well tolerated, patients should be aware of key safety guidelines:

Common Mild Side Effects

• Dizziness or lightheadedness when rising quickly (postural hypotension)

• Mild fatigue or drowsiness

• Increased urinary frequency during the first few weeks

• Headaches or mild gastrointestinal upset

Contraindications & Warnings

• Pregnancy Warning: Contraindicated during pregnancy. Drugs affecting the renin-angiotensin system (like Telmisartan) can cause severe fetal injury or death when used during the second and third trimesters.

• Lactation: Nursing mothers should consult their physician, as therapy may require discontinuation or switching to alternative treatments.

• Electrolyte Monitoring: Periodic blood tests are recommended to monitor serum potassium, sodium, and renal function parameters (uric acid, creatinine).

• Liver & Kidney Impairment: Requires cautious administration and tailored dosage monitoring in patients with biliary obstructive disorders or severe renal dysfunction.

Authentic Quality 

TELMISTRUM TRIO 6.25 is manufactured under strict WHO-GMP-certified guidelines by Steris Healthcare Pvt. Ltd. Each 10-tablet strip is sealed in light-resistant, moisture-proof blister packaging to maintain chemical stability, dosage accuracy, and therapeutic potency.

Frequently Asked Questions

Where can I buy Telmisartan 40 mg, Cilnidipine 10 mg and Chlorthalidone 6.25 mg online?

You can buy Telmisartan 40 mg, Cilnidipine 10 mg and Chlorthalidone 6.25 mg online through a licensed pharmacy or authorized healthcare provider, subject to product availability and applicable prescription requirements. Always verify the product details and seller before ordering.

What is the price of Telmisartan 40 mg, Cilnidipine 10 mg and Chlorthalidone 6.25 mg?

The price of Telmisartan 40 mg, Cilnidipine 10 mg and Chlorthalidone 6.25 mg varies depending on the brand, pack size, pharmacy, and current offers. Check the authorized seller's current product listing for the latest price.

Can I order Telmisartan 40 mg, Cilnidipine 10 mg and Chlorthalidone 6.25 mg online?

Yes, you can order Telmisartan 40 mg, Cilnidipine 10 mg and Chlorthalidone 6.25 mg online through a licensed pharmacy, provided the product is available and any applicable prescription requirements are met.

Is Telmisartan 40 mg, Cilnidipine 10 mg and Chlorthalidone 6.25 mg available from Steris Healthcare?

Availability depends on the current product listing and stock at Steris Healthcare. Check the relevant Steris Healthcare product page or contact the company directly to confirm availability before placing an order.

What is Telmisartan 40 mg, Cilnidipine 10 mg and Chlorthalidone 6.25 mg used for?

This combination may be prescribed for the management of high blood pressure (hypertension) when treatment with multiple antihypertensive medicines is considered appropriate. Telmisartan is an angiotensin II receptor blocker, cilnidipine is a calcium-channel blocker, and chlorthalidone is a diuretic. Use this combination only under the supervision of a qualified healthcare professional.

What is the composition of Telmisartan 40 mg, Cilnidipine 10 mg and Chlorthalidone 6.25 mg?

The stated composition is Telmisartan 40 mg + Cilnidipine 10 mg + Chlorthalidone 6.25 mg as the active ingredients. The complete formulation and inactive ingredients may vary by manufacturer, so check the product packaging or official product information.

Is a prescription required?

A prescription may be required for this combination because it contains prescription medicines. Follow the requirements of the licensed pharmacy and applicable local regulations when purchasing it.

How should Telmisartan 40 mg, Cilnidipine 10 mg and Chlorthalidone 6.25 mg be taken?

Take the medicine exactly as prescribed by your doctor. Follow the recommended dose and schedule, and do not increase, reduce, or stop treatment without consulting your healthcare professional. Because chlorthalidone is a diuretic, your doctor may provide specific instructions regarding the timing of your dose.

What should I know before buying Telmisartan 40 mg, Cilnidipine 10 mg and Chlorthalidone 6.25 mg?

Before buying, verify the brand, strength, composition, pack size, expiry date, manufacturer, seller authenticity, and prescription requirements. Inform your healthcare professional about your medical conditions and all medicines or supplements you take, particularly if you have kidney, liver, heart, or electrolyte-related problems.

How can I order Telmisartan 40 mg, Cilnidipine 10 mg and Chlorthalidone 6.25 mg online?

To order this combination online, select the correct product and pack size from a licensed pharmacy, provide a valid prescription if required, enter your delivery details, and complete the pharmacy's ordering process. Always confirm the exact strength and formulation before completing your purchase.