UDCHOLIC 150

UDCHOLIC 150 is a premium pharmaceutical formulation of Ursodeoxycholic Acid (UDCA), a bile acid used to treat a variety of liver and gallbladder conditions. With its active ingredient, Ursodeoxycholic Acid at 150mg per tablet, UDCHOLIC 150 has become a trusted choice for patients and healthcare providers alike. This comprehensive guide will explore everything you need to know about UDCHOLIC 150—its uses, benefits, dosing, side effects, and more—helping you make informed decisions about your health or your patients’ care.

What is UDCHOLIC 150?

UDCHOLIC 150 is a brand-name medication containing Ursodeoxycholic Acid (UDCA), a naturally occurring bile acid. It is primarily used to treat liver diseases such as primary biliary cholangitis (PBC), primary sclerosing cholangitis (PSC), and cholestasis of pregnancy. Additionally, UDCHOLIC 150 is effective in dissolving cholesterol gallstones and improving bile flow in patients with impaired bile secretion.

Key Features of UDCHOLIC 150:

• Active Ingredient: Ursodeoxycholic Acid (UDCA)
• Strength: 150mg per tablet
• Formulation: Oral tablets, easy to swallow
• Brand: UDCHOLIC
• Uses: Treatment of liver and gallbladder disorders

Understanding Ursodeoxycholic Acid (UDCA)

What is Ursodeoxycholic Acid?

Ursodeoxycholic Acid (UDCA) is a secondary bile acid that naturally occurs in small amounts in human bile. It has choleretic and cholagogue properties, meaning it stimulates bile production and promotes bile flow from the liver to the intestines. UDCA works by replacing harmful bile acids with gentler ones, protecting liver cells, and improving bile transport.

How Does UDCA Work?

UDCA works through several mechanisms:

1. Hydrophilic Bile Acid Pool Modulation: UDCA increases the concentration of hydrophilic (water-soluble) bile acids in the bile, reducing the toxic effects of hydrophobic bile acids.
2. Protection of Liver Cells: UDCA protects cholangiocytes (bile duct cells) from damage caused by hydrophobic bile acids.
3. Improves Bile Flow: Enhances bile secretion and flow, reducing the buildup of toxic substances in the liver.
4. Gallstone Dissolution: In patients with small cholesterol gallstones, UDCA gradually dissolves them by reducing cholesterol saturation in bile.

Clinical Uses of UDCHOLIC 150

1. Primary Biliary Cholangitis (PBC)

Primary Biliary Cholangitis (PBC) is a chronic autoimmune disease that damages the small bile ducts in the liver, leading to cholestasis (reduced bile flow) and eventually cirrhosis. UDCHOLIC 150 is first-line therapy for PBC.

Benefits in PBC:

• Slows disease progression
• Reduces liver enzyme abnormalities
• Improves survival and delays the need for liver transplantation
• Alleviates fatigue and itching (pruritus)

2. Primary Sclerosing Cholangitis (PSC)

While there is no definitive cure for Primary Sclerosing Cholangitis (PSC), UDCHOLIC 150 is used as an adjunct therapy to manage symptoms and slow disease progression.

Benefits in PSC:

• Improves liver enzyme levels
• May reduce inflammation in bile ducts
• Potential to delay progression to cirrhosis

3. Cholestasis of Pregnancy

Intrahepatic cholestasis of pregnancy (ICP) is a condition where bile acids accumulate in the liver, causing itching and increasing the risk of preterm labor and fetal complications. UDCHOLIC 150 is used to lower bile acid levels and reduce itching, improving maternal and fetal outcomes.

Benefits in ICP:

• Reduces maternal itching
• Lowers serum bile acid levels
• Reduces risk of preterm labor and fetal distress

4. Dissolution of Cholesterol Gallstones

UDCHOLIC 150 is effective in dissolving small, cholesterol-rich gallstones (usually <15 mm in diameter). It works by reducing cholesterol saturation in bile, allowing the gallstones to gradually dissolve over time.

Benefits in Gallstone Management:

• Non-invasive alternative to surgery
• Effective for small, solitary gallstones
• Reduces need for cholecystectomy in selected patients

5. Other Indications

UDCHOLIC 150 may also be used for:

• Post-cholecystectomy bile reflux gastritis
• Non-alcoholic fatty liver disease (NAFLD) – under investigation
• Cystic fibrosis–related cholestasis – under investigation

Benefits of Choosing UDCHOLIC 150

1. Proven Efficacy

UDCHOLIC 150 has been studied extensively in clinical trials and real-world settings. It has a strong evidence base supporting its use in PBC, gallstone dissolution, and cholestasis of pregnancy.

2. Well-Tolerated Profile

Compared to other bile acid therapies, UDCHOLIC 150 is generally well-tolerated. Most patients experience minimal side effects, making it a preferred choice for long-term therapy.

3. Improved Quality of Life

By reducing symptoms such as pruritus (itching), fatigue, and abdominal discomfort, UDCHOLIC 150 significantly improves patients’ quality of life.

4. Supports Liver Health

UDCHOLIC 150 not only treats symptoms but also protects liver cells, improves bile flow, and slows the progression of liver disease.

5. Convenient Oral Formulation

UDCHOLIC 150 is available in easy-to-swallow tablets, making it a convenient and patient-friendly option for long-term therapy.

Dosing and Administration of UDCHOLIC 150

General Dosing Guidelines

The dosing of UDCHOLIC 150 may vary depending on the condition being treated. Always follow your healthcare provider’s instructions and use the medication exactly as prescribed.

1. Primary Biliary Cholangitis (PBC):

• Adult Dose: 13–15 mg/kg/day, divided into two doses, taken with meals.
• Typical Dose: For a 60 kg patient, this equals 780–900 mg/day (approximately 5–6 tablets of UDCHOLIC 150).

2. Cholesterol Gallstone Dissolution:

• Adult Dose: 8–10 mg/kg/day, divided into two doses, taken with meals.
• Typical Dose: For a 60 kg patient, this equals 480–600 mg/day (approximately 3–4 tablets of UDCHOLIC 150).
• Treatment Duration: 6–24 months, with periodic ultrasound monitoring to assess gallstone dissolution.

3. Cholestasis of Pregnancy (ICP):

• Adult Dose: 10–15 mg/kg/day, divided into two doses, taken with meals.
• Typical Dose: For a 60 kg patient, this equals 600–900 mg/day (approximately 4–6 tablets of UDCHOLIC 150).
• Treatment Duration: Throughout the duration of the pregnancy.

Administration Tips

• Take with Food: UDCHOLIC 150 should be taken with meals to enhance absorption.
• Do Not Crush or Chew: Swallow the tablets whole.
• Consistency is Key: Take the medication at the same times each day to maintain steady blood levels.
• Stay Hydrated: Adequate hydration supports bile flow and overall liver health.

Safety Profile and Side Effects of UDCHOLIC 150

Common Side Effects

UDCHOLIC 150 is generally well-tolerated, but like all medications, it can cause side effects. Most are mild and transient.

1. Gastrointestinal:

• Diarrhea
• Nausea
• Abdominal pain
• Dyspepsia (indigestion)

2. Liver-Related:

• Elevated liver enzymes (ALT, AST)
• Rare cases of hepatitis or liver dysfunction

3. Other:

• Headache
• Rash
• Fatigue (rare)

Serious Side Effects (Rare)

Although rare, serious side effects can occur and require immediate medical attention:

1. Hepatotoxicity:

• Severe liver injury or dysfunction
• Symptoms: Jaundice, dark urine, severe fatigue, abdominal pain

2. Allergic Reactions:

• Rash, itching, swelling, difficulty breathing

3. Severe Diarrhea:

• Can lead to dehydration and electrolyte imbalance

Precautions and Contraindications

1. Liver Function Monitoring:

• Regular monitoring of liver function tests (LFTs) is recommended, especially during the first few months of therapy.

2. Pregnancy and Breastfeeding:

• Pregnancy: UDCHOLIC 150 is generally safe during pregnancy, especially for cholestasis of pregnancy.
• Breastfeeding: Limited data is available; consult your healthcare provider before use.

3. Pediatric Use:

• Not typically recommended for children unless prescribed by a pediatric specialist.

4. Renal Impairment:

• Dose adjustments may be necessary in patients with severe renal impairment.

5. Allergy to Bile Acids:

• Avoid use in patients with a known hypersensitivity to UDCA or other bile acids.

Drug Interactions with UDCHOLIC 150

Common Drug Interactions

UDCHOLIC 150 has few drug interactions, but it’s important to be aware of potential interactions with other medications.

1. Antacids:

• May reduce the absorption of UDCA.
• Recommendation: Take UDCHOLIC 150 at least 2 hours before or after antacids.

2. Cholesterol-Lowering Medications (e.g., Statins):

• Generally safe to use together, but monitor liver function.

3. Immunosuppressants (e.g., Cyclosporine):

• May increase the risk of liver toxicity.
• Recommendation: Use with caution and monitor liver enzymes closely.

4. Chemotherapy Agents:

• May increase the risk of hepatotoxicity.
• Recommendation: Use under close supervision of a hepatologist or oncologist.

Herbal and Dietary Supplements

• St. John’s Wort: May induce liver enzymes, potentially affecting UDCA metabolism.
• High-dose Vitamin A: Can increase liver stress.
• Always consult your healthcare provider before combining UDCHOLIC 150 with any supplements.

Why Choose UDCHOLIC 150?

1. Trusted Brand Name

UDCHOLIC is a reputable and trusted brand in the pharmaceutical industry. It is known for its high-quality manufacturing standards, strict quality control, and commitment to patient safety.

2. Precise Dosage Strength

With each tablet containing 150mg of Ursodeoxycholic Acid, UDCHOLIC 150 offers precise dosing, ensuring optimal therapeutic effects while minimizing the risk of overdose.

3. Easy-to-Swallow Tablets

UDCHOLIC 150 is available in compact, easy-to-swallow tablets, making it a convenient option for patients who may have difficulty with larger capsules or liquids.

4. Manufactured Under Strict Guidelines

UDCHOLIC 150 is produced in FDA-approved facilities that adhere to Good Manufacturing Practices (GMP). This ensures consistent quality, purity, and potency with every tablet.

5. Global Availability

UDCHOLIC 150 is available in multiple countries, making it accessible to patients worldwide. Its wide availability ensures that patients can continue their therapy without interruption.

Conclusion: Why UDCHOLIC 150 is a Smart Choice for Liver and Gallbladder Health

UDCHOLIC 150 is more than just a medication—it’s a comprehensive solution for managing liver and gallbladder disorders. With its proven efficacy, excellent safety profile, and easy-to-use formulation, UDCHOLIC 150 has become a go-to therapy for patients and healthcare providers alike.

Whether you’re managing primary biliary cholangitis, dissolving cholesterol gallstones, or treating cholestasis of pregnancy, UDCHOLIC 150 offers targeted, long-term support for your liver and gallbladder health. Its precise dosing, trusted brand reputation, and global availability make it a smart and reliable choice for anyone seeking effective treatment.

Frequently Asked Questions (FAQs) About UDCHOLIC 150

Q1. How long does it take to see results with UDCHOLIC 150?

A: In conditions like primary biliary cholangitis, improvements in liver enzyme levels can be seen within 3–6 months. For gallstone dissolution, it may take 6–24 months to see significant results. In cholestasis of pregnancy, symptom relief (especially itching) may occur within days to weeks.

Q2. Can UDCHOLIC 150 be taken with food?

A: Yes, UDCHOLIC 150 should be taken with meals to enhance absorption and reduce gastrointestinal side effects.

Q3. Are there any dietary restrictions while taking UDCHOLIC 150?

A: No specific dietary restrictions are required, but maintaining a balanced diet and adequate hydration supports overall liver health. Patients with gallstones may be advised to follow a low-fat diet to reduce bile acid stimulation.

Q4. Is UDCHOLIC 150 safe for long-term use?

A: Yes, UDCHOLIC 150 is generally safe for long-term use in conditions like PBC, provided that regular monitoring of liver function and electrolytes is performed.

Q5. Can UDCHOLIC 150 cause weight gain?

A: Weight gain is not a common side effect of UDCHOLIC 150. However, in patients with PBC, improved liver function may lead to increased appetite and weight gain as a secondary effect.

Q6. What should I do if I miss a dose of UDCHOLIC 150?

A: If you miss a dose, take it as soon as you remember. If it’s almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double-dose.

Q7. Can UDCHOLIC 150 be used in children?

A: UDCHOLIC 150 is not typically recommended for children unless prescribed by a pediatric specialist. Dosing in children is weight-based and must be carefully monitored.

Q8. How should UDCHOLIC 150 be stored?

A: Store UDCHOLIC 150 at room temperature, in a dry and cool place, and away from direct sunlight. Keep the medication out of reach of children and pets.