PAFAGOLD M 500

What is PAFAGOLD M 500?

PAFAGOLD M 500 contains the powerful combination of Dapagliflozin and Metformin Hydrochloride, two well-known oral antidiabetic agents used for the management of type 2 diabetes mellitus. This fixed-dose combination is designed to help control blood sugar levels in adults when diet and exercise alone are not sufficient.

• Dapagliflozin belongs to the SGLT2 (sodium-glucose co-transporter-2) inhibitor class, which works by preventing glucose reabsorption in the kidneys, allowing excess sugar to be excreted through urine.

• Metformin Hydrochloride belongs to the biguanide class and works by decreasing glucose production in the liver, improving insulin sensitivity, and enhancing glucose uptake by the muscles.
  When combined, these two drugs provide a dual mechanism to help patients achieve better glycemic control.

Uses of Dapagliflozin + Metformin Hydrochloride

This medication is prescribed for:

1. Type 2 Diabetes Mellitus: Helps manage blood glucose levels effectively.

2. Cardiovascular Benefits: Dapagliflozin may reduce the risk of hospitalization for heart failure in diabetic patients with cardiovascular risk factors.

3. Weight Management Support: May aid in modest weight reduction due to loss of excess sugar through urine.

4. Improved Insulin Sensitivity: Helps the body use insulin more effectively, improving long-term blood sugar control.

Side Effects of PAFAGOLD M 500

Like all medicines, Dapagliflozin and Metformin Hydrochloride tablets may cause side effects. Common ones include:

• Urinary tract infections (UTIs)

• Increased urination

• Nausea or vomiting

• Diarrhea or stomach discomfort

• Headache

• Genital infections (e.g., yeast infection)

Rare but serious side effects may include:

• Lactic acidosis (a rare but serious complication linked to metformin)

• Ketoacidosis (even with normal blood sugar levels)
  Seek medical help immediately if you notice symptoms such as severe abdominal pain, rapid breathing, confusion, extreme weakness, or irregular heartbeat.

Precautions Before Using PAFAGOLD M 500

Before starting PAFAGOLD M 500, inform your doctor if you:

• Have kidney or liver problems

• Have a history of urinary tract or genital infections

• Are on a low carbohydrate or ketogenic diet

• Have heart problems or low blood pressure

• Are pregnant, planning pregnancy, or breastfeeding

• Have dehydration or frequent episodes of vomiting/diarrhea

Drug Interactions

Dapagliflozin and Metformin Hydrochloride may interact with:

• Diuretics (may increase the risk of dehydration or low blood pressure)

• Insulin or other antidiabetic medicines (may increase the risk of hypoglycemia)

• Blood pressure medications (may enhance their effect)

• Iodinated contrast agents (used in certain imaging procedures; metformin should be stopped before and after contrast use due to kidney risk)

Always provide your complete medication list to your healthcare provider before starting this medicine.

Conclusion

PAFAGOLD M 500 is a highly effective, dual-action antidiabetic tablet that helps manage type 2 diabetes by lowering blood sugar levels through complementary mechanisms. Dapagliflozin supports glucose elimination via the kidneys, while Metformin Hydrochloride reduces sugar production and enhances insulin sensitivity. Together, they improve glycemic control, support weight management, and may provide cardiovascular benefits.

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