S LACTONE 50

S Lactone 50 contains Spironolactone 50 mg. Spironolactone belongs to a class called mineralocorticoid receptor antagonists (MRAs), or aldosterone antagonists. It is also known as a potassium-sparing diuretic.

What is aldosterone? Aldosterone is a hormone made by the adrenal glands. It tells the kidneys to hold on to salt and water and to push out potassium. In healthy people this keeps blood volume balanced. In heart failure, liver cirrhosis and some forms of high blood pressure, aldosterone is overactive, which leads to:

• Fluid build-up in the legs, lungs or abdomen
• Higher blood pressure
• Stiffening and scarring (fibrosis) of heart muscle and blood vessels
• Loss of potassium (which can cause weakness and rhythm problems)

How spironolactone works: It blocks aldosterone's receptor in the kidney and other tissues. The kidneys then release more salt and water in the urine while keeping potassium in the body. This is the opposite of many common "water tablets" (such as furosemide), which waste potassium. Spironolactone's protective effect on the heart and blood vessels also comes from calming aldosterone's scarring action.

Where does 50 mg fit? Spironolactone is usually started at a low dose and adjusted. In heart failure the target is often 25 to 50 mg once daily. In high blood pressure and fluid retention, higher doses may be needed. The 50 mg tablet is a versatile mid-range strength: doctors often reach it by titration, and it can be taken as a full tablet or split as advised. Your doctor sets the final dose from your blood pressure, kidney function and potassium levels.

The tablet is manufactured by Steris Healthcare Pvt. Ltd., Jaipur, a WHO-GMP and ISO certified pharmaceutical company.

Product Information

Why Is S Lactone 50 Important?

1. Heart failure is a serious and growing problem. In heart failure the heart cannot pump efficiently, causing breathlessness, swelling and tiredness. The landmark RALES trial (NEJM, 1999) showed that adding spironolactone to standard treatment in patients with severe heart failure reduced the risk of death by about 30% and lowered hospitalisations. Spironolactone is now a standard part of treatment for heart failure with reduced ejection fraction.

2. Resistant high blood pressure needs a third or fourth drug. Some people stay above target despite three medicines. In the PATHWAY-2 trial (Lancet, 2015), spironolactone lowered blood pressure more than the other add-on options tested in this group, which is why guidelines often recommend it as the next step.

3. Fluid retention makes life uncomfortable and dangerous. In liver cirrhosis with ascites (fluid in the abdomen), spironolactone is a first-line diuretic, often alongside a loop diuretic. In kidney and heart disease, it helps clear swelling and ease breathing.

4. It protects potassium. Many diuretics drain potassium. Spironolactone preserves it, which can be useful in people who would otherwise need potassium supplements.

5. Careful use is the whole point. The same potassium-sparing action that helps can raise potassium too high, especially in kidney disease or when combined with certain medicines. Blood tests and a few lifestyle precautions make it safe and effective.

India-specific point: Coconut water, bananas, oranges, potatoes, tomato soups and "low-sodium salt" substitutes (which often contain potassium chloride) are common in Indian households and can add significant potassium. People on spironolactone should ask their doctor before using these in large amounts.

Key Benefits 

• Improves outcomes in heart failure. It reduces fluid overload and has been shown to lower the risk of hospitalisation and death in suitable patients.
• Lowers blood pressure. It is especially effective when blood pressure stays high despite other medicines.
• Clears fluid retention. It reduces swelling and abdominal fluid in liver, kidney and heart conditions.
• Spares potassium. It helps avoid the low potassium that many other diuretics cause.
• Protects the heart and vessels. By blocking aldosterone, it reduces harmful scarring and stiffening.
• Treats primary hyperaldosteronism. It directly counters the excess hormone.
• Once-daily convenience. Most patients take it once a day.
• Reliable manufacturing. Produced by Steris Healthcare under WHO-GMP standards.

Spironolactone 50 mg Uses

Your doctor may prescribe it for:

• Heart failure, as an add-on to standard therapy
• Essential hypertension (high blood pressure), including resistant hypertension
• Oedema (fluid retention) in congestive heart failure, liver cirrhosis with ascites, and nephrotic syndrome
• Primary hyperaldosteronism (Conn's syndrome), for diagnosis support or treatment
• Low potassium (hypokalaemia) that is not controlled by other measures

Doctor-directed uses beyond standard labelling: In some patients, specialists prescribe spironolactone for hormone-related conditions in women, such as persistent acne, excess facial or body hair and female-pattern hair thinning, because it blocks androgen (male hormone) effects. These uses are decided by the doctor case by case and are not suitable for self-treatment. Do not take it for these reasons without a prescription.

Precautions: What to Know Before Taking 

Do not take this medicine if you:

• Have high blood potassium (hyperkalaemia)
• Have Addison's disease (adrenal insufficiency)
• Have severe kidney impairment, acute kidney failure or are unable to pass urine (anuria)
• Are allergic to spironolactone or any ingredient in the tablet
• Are taking eplerenone

Speak to your doctor first if you:

• Have kidney disease or diabetes, since both raise the risk of high potassium
• Have liver disease, as dosing and monitoring need care
• Are pregnant or planning pregnancy. Spironolactone can affect a developing male baby's hormonal development, so it is generally avoided in pregnancy unless the doctor decides otherwise.
• Are breastfeeding. A breakdown product of spironolactone passes into breast milk.
• Take ACE inhibitors, ARBs, sacubitril/valsartan, potassium supplements, trimethoprim, NSAIDs, lithium or digoxin (see interactions)
• Are elderly or often dehydrated
• Have low sodium levels or are on a very low-salt diet

Side Effects 

Many people tolerate spironolactone well, especially at lower doses. Side effects are often dose-related.

Common:

• Increased urination
• Dizziness or light-headedness
• Headache
• Nausea, stomach upset or cramps
• Tiredness
• Breast tenderness or enlargement in men (gynaecomastia)
• Menstrual irregularities or breast tenderness in women

Less common:

• Low sodium levels (confusion, weakness)
• Dehydration or low blood pressure
• Reduced sex drive or erectile difficulty
• Skin rash or itching
• Hair changes or increased facial hair in women (usually at higher doses)
• Muscle cramps
• Dry mouth or increased thirst

Frequently Asked Questions

Where can I buy Spironolactone 50 mg online?

Spironolactone 50 mg can be purchased through licensed pharmacies or authorized pharmaceutical suppliers. Check the product details and prescription requirements before placing an order.

What is the price of Spironolactone 50 mg?

The price of Spironolactone 50 mg may vary depending on the brand, pack size, seller, availability, and applicable charges. Check the current price before ordering.

Can I order Spironolactone 50 mg online?

Yes, Spironolactone 50 mg can generally be ordered online through a licensed pharmacy or authorized supplier. A valid prescription may be required.

Is Spironolactone 50 mg available from Steris Healthcare?

Availability of Spironolactone 50 mg from Steris Healthcare depends on the current product range and stock status. Contact Steris Healthcare to confirm availability before ordering.

What is Spironolactone 50 mg used for?

Spironolactone 50 mg is a potassium-sparing diuretic and aldosterone antagonist. It may be prescribed for conditions such as hypertension, fluid retention associated with certain medical conditions, heart failure, and hyperaldosteronism.

What is the composition of Spironolactone 50 mg?

Spironolactone 50 mg contains spironolactone 50 mg as the active pharmaceutical ingredient. Check the product packaging for complete formulation details.

Is a prescription required?

Yes, Spironolactone 50 mg is generally a prescription medicine and should be used under the supervision of a qualified healthcare professional.

How should Spironolactone 50 mg be taken?

Take Spironolactone 50 mg exactly as prescribed by your doctor. Follow the recommended dose and timing, and do not change the dose or stop treatment without medical advice.

What should I know before buying Spironolactone 50 mg?

Before buying, verify the strength, composition, dosage form, pack size, manufacturer, expiry date, and storage instructions. Inform your doctor about kidney problems, high potassium levels, pregnancy, allergies, or other medicines you are taking, particularly potassium supplements or medicines that can increase potassium levels.

How can I order Spironolactone 50 mg online?

To order Spironolactone 50 mg online, use a licensed pharmacy or authorized pharmaceutical supplier. Confirm product availability, provide a valid prescription if required, review the product details, and follow the supplier's ordering and payment process.