PERINDPRIM PLUS

PERINDPRIM PLUS is a combination pharmaceutical formulation containing Perindopril and Indapamide, designed to effectively manage high blood pressure (hypertension). This tablet is developed to target both fluid retention and blood vessel constriction—two key factors contributing to elevated blood pressure. By combining a diuretic (Indapamide) and an ACE inhibitor (Perindopril), PERINDPRIM PLUS offers a dual mechanism to help reduce and stabilize blood pressure levels in patients with mild to moderate hypertension.

What is PERINDPRIM PLUS?

PERINDPRIM PLUS contains two active ingredients:

• Perindopril: an angiotensin-converting enzyme (ACE) inhibitor that helps relax blood vessels and reduce blood pressure by blocking the production of substances that tighten the blood vessels.

• Indapamide: a thiazide-like diuretic that promotes the excretion of sodium and water through the kidneys, helping to reduce fluid volume and thus lower blood pressure.

Perindopril and indapamide are used to treat mild to moderate high blood pressure. Perindopril is an angiotensin-converting enzyme (ACE) inhibitor.

Uses of PERINDPRIM PLUS:

• Treatment of mild to moderate essential hypertension (high blood pressure without a known secondary cause)

• May be prescribed when monotherapy with either an ACE inhibitor or diuretic does not provide sufficient blood pressure control

• Helps in reducing cardiovascular risks such as heart attacks and strokes in hypertensive patients, particularly those with other risk factors

Side Effects of PERINDPRIM PLUS:

Like all medications, PERINDPRIM PLUS may cause some side effects in certain individuals. Common or potential side effects include:

• Dizziness or light-headedness, especially after the first dose

• Dry cough (a known side effect of ACE inhibitors like Perindopril)

• Headache or fatigue

• Low potassium levels (hypokalemia)

• Increased urination due to the diuretic effect of Indapamide

• Muscle cramps or weakness

• Allergic reactions, such as skin rash or swelling
  Seek immediate medical attention if you experience chest pain, difficulty breathing, or swelling of the face, lips, or throat.

Precautions Before Using PERINDPRIM PLUS:

• Inform your doctor if you have a history of kidney disease, liver impairment, diabetes, or electrolyte imbalances

• Avoid alcohol consumption, which can further lower blood pressure and increase side effects

• Do not use during pregnancy or breastfeeding, as it may harm the fetus or infant

• Regular monitoring of blood pressure, kidney function, and electrolyte levels is advised during therapy

• Caution is advised in elderly patients or those on a sodium-restricted diet

Drug Interactions – What Drugs Interact with PERINDPRIM PLUS?

PERINDPRIM PLUS may interact with several other medications. Always inform your healthcare provider about all the drugs you are taking. Significant interactions include:

• Potassium-sparing diuretics (e.g., spironolactone, amiloride): May increase potassium levels, leading to hyperkalemia

• NSAIDs (e.g., ibuprofen, naproxen): May reduce the antihypertensive effect and affect kidney function

• Lithium: Increased risk of lithium toxicity

• Antidiabetic agents (insulin or oral hypoglycemics): May enhance blood sugar-lowering effect, requiring dose adjustments

• Other antihypertensives: Risk of additive blood pressure-lowering effects

• Ciclosporin or Tacrolimus: Increased risk of hyperkalemia

• ACE inhibitors or ARBs with aliskiren: Not recommended, especially in patients with diabetes or kidney disease

Conclusion:

PERINDPRIM PLUS is a powerful, combination antihypertensive that offers enhanced control of blood pressure through dual action. With proper medical guidance, lifestyle modification, and regular monitoring, it can significantly reduce the risks associated with uncontrolled hypertension. Always take PERINDPRIM PLUS exactly as prescribed by your physician and follow up regularly for best outcomes.