OLMISTRUM CH 40

OLMISTRUM CH 40 is a dual-combination antihypertensive prescription medication formulated with Olmesartan Medoxomil IP (40 mg) and Chlorthalidone IP (12.5 mg). Manufactured and marketed in India by Steris Healthcare Pvt. Ltd. in 10-tablet blister strips, this combination provides 24-hour blood pressure control for adults with Stage 2 essential hypertension or uncontrolled blood pressure on single-agent treatments.

Why Buy OLMISTRUM CH 40? Key Clinical Benefits

Persistent high blood pressure damages blood vessels, raising the risk of myocardial infarction, stroke, heart failure, and renal decline. Combining Olmesartan and Chlorthalidone offers several clinical advantages over standard monotherapies:

• High-Potency BP Reduction: Combines maximum-dose ARB therapy (40mg Olmesartan) with an extended-release diuretic (12.5mg Chlorthalidone) for dual-pathway arterial control.

• Extended 24-Hour Coverage: Chlorthalidone features a long elimination half-life (40–50 hours), delivering smoother, longer-lasting blood pressure control than short-acting diuretics like hydrochlorothiazide (HCTZ).

• Prevention of Early-Morning Spikes: Keeps blood pressure stable through the night and into the early morning hours, when cardiovascular events are most likely to occur.

• End-Organ & Renal Protection: Relaxes tight blood vessels to lower pressure inside the heart and kidneys, slowing hypertensive organ damage.

• Single-Pill Adherence: Replaces two individual daily pills with a single fixed-dose tablet, simplifying daily regimens and improving long-term adherence.

How OLMISTRUM CH 40 Works (Dual Mechanism of Action)

OLMISTRUM CH 40 combines two complementary active ingredients to provide round-the-clock blood pressure control:

1. Olmesartan Medoxomil (40 mg) – ARB

Olmesartan Medoxomil is a prodrug that is rapidly converted to its active metabolite, Olmesartan, during absorption from the gastrointestinal tract. It selectively blocks Angiotensin II from binding to $AT_1$ receptors in vascular smooth muscle and the adrenal gland. By preventing Angiotensin II binding, it stops hormone-induced vasoconstriction, decreases total peripheral resistance, and lowers aldosterone secretion to promote vascular relaxation.

2. Chlorthalidone (12.5 mg) – Thiazide-like Diuretic

Chlorthalidone acts on the renal tubular epithelium in the distal convoluted tubule of the nephron, inhibiting the sodium-chloride ($\text{Na}^+/\text{Cl}^-$) cotransporter. This increases the excretion of sodium, chloride, and accompanying water molecules into the urine, decreasing plasma volume and overall cardiac preload. Over time, Chlorthalidone also reduces total peripheral vascular resistance.

Indications & Clinical Applications

Physicians across India prescribe OLMISTRUM CH 40 for:

1. Stage 2 Essential Hypertension: For adult patients requiring combination therapy to achieve target blood pressure goals.

2. Treatment-Resistant Hypertension: For patients whose blood pressure remains uncontrolled on single-agent ARB or diuretic monotherapy.

3. Cardiovascular Risk Reduction: Lowering elevated blood pressure to reduce long-term risks of stroke, fatal or non-fatal heart attacks, and progressive kidney damage.

Dosage & Administration Guidelines

Always take OLMISTRUM CH 40 exactly as prescribed by your doctor.

• Recommended Dose: Typically one tablet once daily in the morning.

• How to Take: Swallow the tablet whole with a glass of water. Do not break, crush, or chew the tablet.

• Timing: Take your dose at the same time every morning. Taking it early in the day helps prevent nighttime trips to the bathroom due to the diuretic effect.

• Missed Dose: If you miss a dose, take it as soon as you remember. If it is almost time for your next scheduled dose, skip the missed tablet and resume your regular dosing schedule. Never double up on doses.

Safety Profile, Side Effects & Precautions

While OLMISTRUM CH 40 is well tolerated by most adults under medical supervision, patients should be aware of key safety guidelines.

Common Mild Side Effects

• Dizziness or lightheadedness when rising quickly (orthostatic hypotension)

• Increased urinary frequency during the first few weeks of treatment

• Mild fatigue, headache, or weakness

• Muscle cramps or mild thirst

Critical Contraindications & Warnings

• Pregnancy Warning: Strictly contraindicated during pregnancy. Drugs acting directly on the renin-angiotensin system (like Olmesartan) can cause severe fetal injury or death during the second and third trimesters.

• Lactation: Consult your doctor before taking this medication while breastfeeding, as alternative treatments may be recommended.

• Anuria & Severe Kidney Dysfunction: Contraindicated in patients who are unable to urinate or who have severe renal impairment.

• Electrolyte Monitoring: Periodic blood tests are recommended to monitor serum potassium, sodium, uric acid, and blood urea nitrogen (BUN) levels.

Quality Assurance by Steris Healthcare Pvt. Ltd.

OLMISTRUM CH 40 is manufactured by Steris Healthcare Pvt. Ltd. in WHO-GMP and ISO-certified pharmaceutical production facilities in India. Every 10-tablet strip uses light-impermeable, moisture-barrier blister packaging to maintain stability and active drug potency throughout its shelf life.

Frequently Asked Questions

Where can I buy Olmesartan and Chlorthalidone online?

Olmesartan and Chlorthalidone can be purchased online through authorized pharmacies and pharmaceutical suppliers, subject to applicable prescription requirements. Always verify the product strength, manufacturer, and expiry date before purchasing.

What is the price of Olmesartan and Chlorthalidone?

The price depends on the specific strength, brand, pack size, and manufacturer. For the latest price, check the product listing or contact the authorized pharmaceutical supplier.

Can I order Olmesartan and Chlorthalidone online?

Yes, Olmesartan and Chlorthalidone may be ordered online through legitimate pharmaceutical platforms. A valid prescription may be required, so follow the seller's prescription and dispensing requirements.

Is Olmesartan and Chlorthalidone available from Steris Healthcare?

Availability depends on the specific product strength and current stock. You can contact Steris Healthcare to confirm availability, pack size, pricing, and ordering details.

What is Olmesartan and Chlorthalidone used for?

Olmesartan and Chlorthalidone are used together to help control high blood pressure (hypertension). Olmesartan helps relax blood vessels by blocking the action of angiotensin II, while Chlorthalidone is a diuretic that helps the body remove excess sodium and water.

What is the composition of Olmesartan and Chlorthalidone?

The combination contains Olmesartan Medoxomil and Chlorthalidone. The exact amount of each ingredient depends on the particular formulation. Common formulations may contain Olmesartan 20 mg with Chlorthalidone 12.5 mg, but the product label should always be checked for the exact composition.

Is a prescription required for Olmesartan and Chlorthalidone?

Yes. Olmesartan and Chlorthalidone is a prescription medicine and should be used under the guidance of a qualified healthcare professional. Do not start, stop, or change the dosage without medical advice.

How should Olmesartan and Chlorthalidone be taken?

Take Olmesartan and Chlorthalidone exactly as prescribed by your doctor. It is generally taken orally, preferably at the recommended time each day. Because Chlorthalidone can increase urination, your doctor may advise taking it at a suitable time during the day.

What should I know before buying Olmesartan and Chlorthalidone?

Before buying, verify the product name, strength, composition, manufacturer, pack size, expiry date, and authenticity. Tell your healthcare professional about other medicines you take and any medical conditions. Purchase prescription medicines only from legitimate sources.

How can I order Olmesartan and Chlorthalidone online?

To order online, select the required Olmesartan and Chlorthalidone formulation from an authorized pharmaceutical supplier, verify the strength and pack size, complete any prescription requirements, and provide the required delivery details. For Steris Healthcare products, contact the company to confirm current availability and ordering information.

Order OLMISTRUM CH 40 Online in India

Ordering OLMISTRUM CH 40 (Olmesartan Medoxomil 40mg + Chlorthalidone 12.5mg) through verified healthcare platforms ensures home delivery of authentic medications across India.

• Guaranteed Product Authenticity: Direct distribution from Steris Healthcare Pvt. Ltd. guarantees genuine medications with verified batch details and clear expiration dates.

• Secure Checkout: Upload a valid doctor’s prescription to complete your purchase safely and securely.