NEBIVALVE AM

Hypertension, commonly known as high blood pressure, is one of the most prevalent cardiovascular disorders worldwide and a major risk factor for heart attack, stroke, kidney failure, and other life-threatening complications. In India, the growing incidence of hypertension is closely linked to sedentary lifestyles, stress, unhealthy diets, obesity, diabetes, and genetic predisposition. Effective and sustained blood pressure control is essential to prevent long-term organ damage and improve overall cardiovascular health.

NEBIVALVE AM is a modern antihypertensive combination tablet formulated with Nebivolol and S(-) Amlodipine, two well-established and complementary blood pressure-lowering agents. This combination provides dual-mechanism blood pressure control by targeting both the heart and blood vessels, making it highly effective for patients with moderate to severe hypertension or those inadequately controlled on monotherapy.

This SEO-friendly article offers a detailed overview of NEBIVALVE AM, including its composition, mechanism of action, uses, benefits, dosage, safety profile, precautions, and frequently asked questions.

Composition

Each tablet of NEBIVALVE AM contains:

• Nebivolol – A selective beta-1 adrenergic receptor blocker with nitric oxide–mediated vasodilatory properties

• S- Amlodipine – The pharmacologically active enantiomer of amlodipine, a calcium channel blocker

This advanced combination ensures effective blood pressure reduction with improved tolerability and reduced side effects.

Therapeutic Class

• Therapeutic Class: Antihypertensive combination therapy

• Dosage Form: Oral tablet

• Indication: Management of hypertension and cardiovascular risk reduction

Mechanism of Action

Mechanism of Action of Nebivolol

Nebivolol is a highly selective beta-1 blocker that works through a dual mechanism:

• Blocks beta-1 adrenergic receptors in the heart

• Reduces heart rate and myocardial contractility

• Lowers cardiac output and blood pressure

• Stimulates nitric oxide release from vascular endothelium

• Causes vasodilation and improves endothelial function

Unlike traditional beta blockers, nebivolol has minimal effect on beta-2 receptors, reducing the risk of bronchospasm and metabolic side effects.

Mechanism of Action of S - Amlodipine

S- Amlodipine is a calcium channel blocker that selectively inhibits L-type calcium channels in vascular smooth muscle. This leads to:

• Relaxation of blood vessels

• Reduction in peripheral vascular resistance

• Improved blood flow

• Effective lowering of systolic and diastolic blood pressure

The S-enantiomer offers enhanced efficacy at lower doses with fewer side effects such as pedal edema.

Synergistic Action of NEBIVALVE AM

The combination of Nebivolol and S(-) Amlodipine provides:

• Dual-action blood pressure control

• Improved vascular relaxation and cardiac efficiency

• Better 24-hour blood pressure stability

• Reduced reflex tachycardia

• Enhanced patient compliance

Indications and Uses

NEBIVALVE AM is indicated for:

• Essential hypertension

• Moderate to severe high blood pressure

• Hypertension with increased cardiovascular risk

• Patients not adequately controlled with single-drug therapy

• Hypertensive patients with diabetes or metabolic syndrome (under medical supervision)

Benefits of NEBIVALVE AM

• Effective control of systolic and diastolic blood pressure

• Dual mechanism targeting heart and blood vessels

• Improved endothelial function and blood flow

• Reduced risk of heart attack and stroke

• Better tolerability compared to conventional combinations

• Lower incidence of ankle edema and fatigue

• Suitable for long-term hypertension management

• Once-daily dosing improves treatment adherence

Role in Long-Term Cardiovascular Protection

Uncontrolled hypertension can lead to target organ damage involving the heart, brain, kidneys, and eyes. NEBIVALVE AM helps in:

• Preventing left ventricular hypertrophy

• Reducing arterial stiffness

• Protecting kidney function

• Lowering the risk of cerebrovascular events

• Supporting long-term cardiovascular health

Dosage and Administration

• Dosage should be taken strictly as prescribed by a physician

• Usually administered once daily

• Can be taken with or without food

• Tablet should be swallowed whole with water

• Best taken at the same time each day for optimal blood pressure control

Do not stop the medication abruptly without consulting your doctor.

Side Effects

NEBIVALVE AM is generally well tolerated. However, some patients may experience:

Common Side Effects

• Headache

• Dizziness

• Fatigue

• Flushing

• Mild ankle swelling

Less Common Side Effects

• Slow heart rate

• Gastrointestinal discomfort

• Cold extremities

Most side effects are mild and transient. Consult a doctor if symptoms persist or worsen.

Precautions and Warnings

• Use under medical supervision only

• Caution in patients with bradycardia or heart block

• Dose adjustment may be required in liver impairment

• Not recommended during pregnancy unless clearly advised

• Breastfeeding women should consult a physician

• Avoid abrupt discontinuation

• Regular blood pressure monitoring is advised

Drug Interactions

Nebivolol and S- Amlodipine may interact with:

• Other antihypertensive medications

• Antiarrhythmic drugs

• Certain antidepressants

• Alcohol (may enhance hypotensive effect)

Always inform your healthcare provider about all medications being taken.

Lifestyle Measures to Enhance Effectiveness

• Follow a low-salt, heart-healthy diet

• Maintain a healthy body weight

• Engage in regular physical activity

• Avoid smoking and excessive alcohol consumption

• Manage stress effectively

• Monitor blood pressure regularly

Storage Instructions

• Store in a cool and dry place

• Protect from moisture and direct sunlight

• Keep out of reach of children

Conclusion

NEBIVALVE AM, containing Nebivolol and S- Amlodipine, is an advanced and effective antihypertensive combination designed for comprehensive blood pressure control. By combining heart-rate regulation with potent vasodilation, NEBIVALVE AM ensures stable 24-hour blood pressure management, improved tolerability, and long-term cardiovascular protection.

FAQs

Q1: What is NEBIVALVE AM used for?

NEBIVALVE AM is used to treat high blood pressure and reduce cardiovascular risk.

Q2: Is NEBIVALVE AM safe for long-term use?

Yes, it is safe for long-term use under medical supervision.

Q3: Can NEBIVALVE AM be taken once daily?

Yes, it is usually prescribed once daily for convenient blood pressure control.

Q4: Does NEBIVALVE AM cause swelling of feet?

The risk is lower compared to regular amlodipine due to the S(-) isomer and nebivolol combination.

Q5: Can I stop the medicine if my blood pressure becomes normal?

No. Always consult your doctor before stopping or changing the dose.