MIRAGRON S 25/5

MIRAGRON S 25/5 is a combination therapy containing Mirabegron 25 mg and Solifenacin 5 mg, formulated to provide effective relief from the symptoms of overactive bladder (OAB) such as frequent urination, urgency, and urge incontinence. This advanced dual-action therapy is designed for patients who do not respond adequately to monotherapy with solifenacin alone. The combination has been clinically proven to offer superior control over bladder function compared to increasing the dose of solifenacin alone.

What is MIRAGRON S 25/5?

MIRAGRON S 25/5 is a prescription oral medication that combines two active pharmaceutical ingredients: Mirabegron, a beta-3 adrenergic agonist, and Solifenacin, an antimuscarinic agent. Both work synergistically to relax the bladder muscle and increase bladder capacity, thereby reducing episodes of urgency, frequency, and leakage.

Uses of MIRAGRON S 25/5

This medication is primarily indicated for the treatment of overactive bladder (OAB) in adults.
It helps in managing symptoms such as:

• Frequent need to urinate (frequency)

• Sudden urge to urinate (urgency)

• Involuntary leakage of urine (urge incontinence)

Clinical evidence supports that the mirabegron and solifenacin combination provides statistically superior results in improving bladder control compared to simply increasing the dose of solifenacin monotherapy. This makes MIRAGRON S 25/5 an ideal next-step option for patients unresponsive to solifenacin alone.

How MIRAGRON S 25/5 Works

• Mirabegron 25 mg works by stimulating beta-3 adrenergic receptors in the bladder wall, which relaxes the detrusor muscle and allows the bladder to hold more urine.

• Solifenacin 5 mg blocks muscarinic receptors in the bladder, reducing involuntary contractions that cause urgency and leakage.
  Together, they act on different pathways to provide comprehensive symptom relief.

Possible Side Effects

As with all medications, some patients may experience side effects, which can include:

• Dry mouth

• Constipation

• Headache

• Urinary retention

• Increased blood pressure

• Blurred vision

• Dizziness

Most side effects are mild and manageable. If they persist or worsen, medical attention is advised.

Precautions Before Using MIRAGRON S 25/5

• Inform your doctor if you have severe liver or kidney problems, bladder outlet obstruction, or gastric retention.

• This medicine should be used with caution in patients with uncontrolled hypertension, as mirabegron may increase blood pressure.

• Avoid alcohol consumption, as it may intensify side effects such as drowsiness or dizziness.

• Pregnant and breastfeeding women should consult their doctor before starting this medication.

• Dose adjustment may be needed in elderly patients or those with hepatic or renal impairment.

Drug Interactions

MIRAGRON S 25/5 may interact with:

• Antifungal drugs (e.g., ketoconazole)

• Antidepressants and anticholinergics

• Medications that affect liver enzymes (CYP3A4 inhibitors or inducers)
  Always inform your healthcare provider about any ongoing medications or supplements.

Storage Instructions

Store in a cool, dry place below 25°C. Protect from direct sunlight and moisture. Keep out of reach of children.

Conclusion

MIRAGRON S 25/5 offers a scientifically advanced, well-tolerated treatment for patients suffering from overactive bladder. By combining Mirabegron 25 mg and Solifenacin 5 mg, it provides dual action to control symptoms more effectively than increasing solifenacin dosage alone. For individuals who are not fully satisfied with antimuscarinic monotherapy, MIRAGRON S 25/5 represents a powerful alternative with proven benefits in both symptom relief and quality of life.