MAYORANDIL 5

MAYORANDIL 5 is a clinically trusted cardiac care medication containing Nicorandil 5 mg as its active pharmaceutical ingredient. Nicorandil is a potassium channel opener with nitrate-like properties, used primarily in the management and prevention of angina pectoris (chest pain) associated with coronary artery disease. By improving blood flow to the heart and reducing cardiac workload, MAYORANDIL 5 helps prevent anginal attacks and enhances overall cardiac function.

Manufactured under strict quality control and Good Manufacturing Practices (GMP), MAYORANDIL 5 ensures purity, stability, and consistent therapeutic efficacy. It is prescribed widely by cardiologists for long-term angina management and cardiac protection in patients with ischemic heart conditions.

Composition

• Active Ingredient: Nicorandil 5 mg

• Dosage Form: Film-coated tablet

• Therapeutic Category: Antianginal agent / Vasodilator

How MAYORANDIL 5 Works

Nicorandil, the key component in MAYORANDIL 5, acts through a dual mechanism that uniquely combines the properties of nitrates and potassium channel openers:

1. Nitrate-like Action:
   Nicorandil donates nitric oxide (NO) in the vascular smooth muscle, which activates guanylate cyclase, leading to an increase in cyclic GMP levels. This causes vasodilation of veins and arteries, reducing both preload and afterload on the heart. As a result, oxygen demand of the myocardium is decreased, alleviating angina symptoms.

2. Potassium Channel Opening Action:
   By opening ATP-sensitive potassium channels in vascular smooth muscles, Nicorandil enhances coronary blood flow and protects the heart muscle from ischemic injury. This action improves myocardial oxygenation and prevents coronary artery spasms.

This dual mechanism makes MAYORANDIL 5 a unique antianginal therapy that offers cardioprotection beyond symptomatic relief.

Uses of MAYORANDIL 5

MAYORANDIL 5 (Nicorandil 5 mg) is used in the treatment and prevention of:

• Chronic Stable Angina: To relieve chest pain and prevent its recurrence.

• Coronary Artery Disease (CAD): Improves blood supply to the heart muscles by dilating coronary arteries.

• Post-Angioplasty or Post-Bypass Therapy: Enhances myocardial perfusion and prevents ischemic episodes.

• Ischemic Heart Disease (IHD): Provides symptomatic relief and reduces the frequency of angina attacks.

• Adjunct Therapy: In combination with other cardiac medications like beta-blockers, calcium channel blockers, or nitrates, for comprehensive heart care. 

Key Benefits of MAYORANDIL 5

1. Improves Oxygen Supply to the Heart:
   Nicorandil increases coronary blood flow and decreases the oxygen demand of cardiac muscles, preventing ischemic pain.

2. Dual Mechanism for Better Protection:
   Combines nitrate-like vasodilation with potassium channel opening for enhanced antianginal action.

3. Reduces Frequency and Severity of Angina:
   Regular use minimizes angina attacks, improving patient comfort and physical endurance.

4. Prevents Coronary Artery Spasm:
   Helps maintain smooth coronary circulation, especially beneficial for patients with variant or vasospastic angina.

5. Cardioprotective Role:
   Offers protection to the myocardium during ischemia and reduces oxidative stress on the heart.

6. Better Tolerability:
   Unlike long-acting nitrates, Nicorandil does not commonly cause tolerance or rebound angina, ensuring consistent efficacy.

7. Enhances Quality of Life:
   Patients experience reduced chest discomfort, improved exercise tolerance, and better overall well-being.

Dosage and Administration

• Recommended Dose:
  The usual starting dose is Nicorandil 5 mg twice daily, which may be increased gradually based on the patient’s clinical response and physician’s advice.

• Administration:
  Tablets should be swallowed whole with water, preferably after meals to minimize gastric discomfort.
  Do not crush or chew the tablets.

• Duration of Therapy:
  Long-term use is often required for sustained angina prevention. Follow your doctor’s instructions closely for dosage adjustments.

Mechanism-Based Clinical Advantages

1. Coronary Vasodilation:
   By dilating both large and small coronary arteries, Nicorandil increases oxygen delivery to the ischemic myocardium.

2. Reduced Cardiac Workload:
   Venodilation reduces preload while arterial dilation decreases afterload, easing the stress on the heart.

3. Mitochondrial Protection:
   Nicorandil protects cardiac cells from ischemia-induced injury by preserving mitochondrial function.

4. Endothelial Function Improvement:
   It helps maintain endothelial health, reducing the risk of plaque formation and arterial stiffness. 

Side Effects of MAYORANDIL 5

MAYORANDIL 5 is generally well-tolerated when taken as prescribed. However, some patients may experience mild side effects, which usually subside with continued use:

• Headache (due to vasodilation)

• Dizziness or lightheadedness

• Nausea or vomiting

• Flushing or warmth sensation

• Fatigue or weakness

• Low blood pressure (hypotension)

• Palpitations (occasionally)

Rare side effects:

• Ulceration of the oral or anal mucosa (in long-term high-dose therapy)

• Skin rash or allergic reactions (rare)

If any side effect persists or worsens, contact your healthcare provider immediately.

Precautions and Warnings

1. Medical Supervision Required:
   Use only under the guidance of a qualified physician, especially in patients with severe cardiac conditions.

2. Hypotension Risk:
   Caution is advised in patients with low blood pressure or those taking other vasodilators.

3. Avoid Abrupt Discontinuation:
   Stopping the medication suddenly may increase the risk of angina attacks.

4. Liver or Kidney Impairment:
   Dose adjustment may be necessary based on hepatic or renal function.

5. Pregnancy and Lactation:
   Use only if clearly indicated and prescribed by a healthcare professional.

6. Driving and Machinery:
   As dizziness or lightheadedness may occur, avoid driving or operating heavy machinery immediately after dosing.

Drug Interactions

Inform your doctor about all medications you are taking, including:

• Nitrates and Vasodilators: May enhance hypotensive effects.

• Phosphodiesterase Inhibitors (e.g., Sildenafil): Risk of severe hypotension.

• Antihypertensives and Diuretics: Additive blood pressure-lowering effects.

• Beta-blockers or Calcium Channel Blockers: May be used safely under supervision for synergistic antianginal benefits.

Storage Instructions

• Store below 30°C, in a cool and dry place.

• Protect from light and moisture.

• Keep out of reach of children.

Why Choose MAYORANDIL 5?

MAYORANDIL 5 offers a scientifically balanced solution for effective, long-term angina management. Its dual-action mechanism makes it superior to traditional nitrates by providing sustained vasodilation without tolerance development. The 5 mg dosage is ideal for initiating therapy and ensuring minimal side effects while achieving optimal cardiac protection.

Each tablet of MAYORANDIL 5 is formulated under GMP-certified facilities to deliver consistent potency, stability, and safety. The product is trusted by physicians for its proven efficacy in preventing anginal pain, improving blood flow, and enhancing myocardial health.

Patients using MAYORANDIL 5 can expect significant improvement in cardiac performance, better exercise tolerance, and a marked reduction in chest discomfort, ultimately leading to a more active and confident lifestyle.