LEFLUNOMILE 20

LEFLUNOMILE 20 is a disease-modifying antirheumatic drug (DMARD) containing leflunomide 20 mg, designed to manage the symptoms and progression of autoimmune joint disorders, particularly rheumatoid arthritis (RA). Developed to provide long-term relief, it works by modulating the immune response responsible for joint damage and inflammation. LEFLUNOMILE 20 is a trusted medication offered by Steris Healthcare, ensuring high-quality formulation and effective therapeutic action for chronic inflammatory conditions.

What is Leflunomide?

Leflunomide is a synthetic immunomodulatory agent that interferes with the activity of certain immune cells responsible for chronic inflammation. It primarily works by inhibiting an enzyme called dihydroorotate dehydrogenase, which is involved in the synthesis of pyrimidine—a vital component of DNA and RNA in rapidly dividing cells like lymphocytes. By doing so, it reduces the proliferation of these immune cells, thereby controlling inflammation and joint damage.

Uses of Leflunomide 20 mg:

LEFLUNOMILE 20 is primarily prescribed for:

• Active Rheumatoid Arthritis (RA) – Leflunomide is used to treat active rheumatoid arthritis. This medicine works by stopping the body from producing too many of the immune cells that are responsible for the swelling and inflammation.

• Psoriatic Arthritis – It may also be used off-label for managing symptoms of psoriatic arthritis, helping reduce joint pain, stiffness, and skin symptoms.

• Other Autoimmune Conditions – In select cases, physicians may consider leflunomide for other immune-mediated disorders.

Side Effects of Leflunomide:

Like all medications, LEFLUNOMILE 20 may cause side effects in some individuals. Common side effects include:

• Nausea or diarrhea

• Elevated liver enzymes

• Hair thinning or loss

• Abdominal discomfort

• High blood pressure

• Rash or skin irritation
  Serious but less common side effects can include severe liver toxicity, respiratory issues, or bone marrow suppression. Regular monitoring by a physician is essential.

Precautions Before Using Leflunomide:

• Liver Health: Avoid leflunomide if you have severe liver impairment. Liver function tests must be done before and during treatment.

• Pregnancy & Contraception: Leflunomide is contraindicated in pregnancy due to the risk of birth defects. Women of childbearing potential should use effective contraception during and after treatment until drug elimination is confirmed.

• Immunosuppression: Since it lowers immune function, avoid contact with infections or live vaccines.

• Renal or Respiratory Disorders: Caution is advised in patients with kidney disease or pre-existing lung problems.

• Alcohol: Alcohol consumption should be limited to reduce the risk of liver damage.

Drug Interactions – What Drugs Interact with Leflunomide?

LEFLUNOMILE 20 may interact with several medications, potentially increasing toxicity or reducing efficacy. These include:

• Methotrexate or other DMARDs – Risk of enhanced liver damage or bone marrow suppression.

• Warfarin (blood thinner) – Leflunomide may increase bleeding risk when used together.

• Rifampin – May increase leflunomide blood levels and risk of side effects.

• Cholestyramine or activated charcoal – Used to remove leflunomide from the body in case of toxicity.

• Live vaccines – Should be avoided during treatment due to immunosuppressive effects.

Conclusion:

LEFLUNOMILE 20 (Leflunomide 20 mg) is a powerful and clinically proven medication to manage autoimmune joint diseases like rheumatoid arthritis. By controlling the immune system’s overactivity, it not only relieves symptoms but also helps prevent long-term joint damage. However, due to its potential side effects and drug interactions, it must be used under the supervision of a healthcare provider with regular monitoring. With proper medical guidance, LEFLUNOMILE 20 can significantly enhance the quality of life in patients battling chronic inflammatory arthritis.