GLISITAPTIN M KIT

GLISITAPTIN M KIT is a powerful anti-diabetic combination therapy containing sitagliptin phosphate 100 mg and metformin hydrochloride 1000 mg. It is used in the effective management of Type 2 Diabetes Mellitus, helping patients control high blood sugar levels and reduce the risk of diabetic complications. This dual-action therapy improves insulin sensitivity and enhances natural insulin production.

If you're looking for a reliable formulation of sitagliptin phosphate and metformin hydrochloride tablets, GLISITAPTIN M KIT is designed to deliver clinically proven results with better glycemic control and fewer side effects.

What is Sitagliptin Phosphate and Metformin Hydrochloride?

Sitagliptin Phosphate is a DPP-4 (Dipeptidyl Peptidase-4) inhibitor that increases the levels of incretin hormones, enhancing insulin release and reducing glucose production in the liver.

Metformin Hydrochloride is a biguanide that works by improving insulin sensitivity and reducing hepatic glucose output. It also decreases intestinal absorption of glucose.

Together, they form a synergistic combination that offers better control of blood sugar in patients with Type 2 Diabetes Mellitus.

Uses of Sitagliptin Phosphate and Metformin Hydrochloride Tablets

GLISITAPTIN M KIT is prescribed for:

• Type 2 Diabetes Mellitus management in adults

• Inadequate glycemic control on metformin alone

• Reduction of HbA1c levels

• Improving insulin sensitivity and glucose utilization

• Delaying progression of diabetic complications such as neuropathy, retinopathy, and nephropathy

metformin hydrochloride 1000 mg uses also include management of insulin resistance and metabolic syndrome in overweight individuals.

Side Effects of Sitagliptin Phosphate and Metformin Hydrochloride Tablets

While generally well-tolerated, some patients may experience:

• Nausea or vomiting

• Diarrhea or abdominal discomfort

• Loss of appetite

• Headache

• Weakness or fatigue

• Flatulence

Rare but serious side effects include:

• Lactic acidosis (a rare, life-threatening condition with metformin)

• Pancreatitis (in rare cases due to sitagliptin)

• Hypoglycemia (especially when used with other anti-diabetics)

Precautions Before Using

Before starting GLISITAPTIN M KIT, consult your physician if you:

• Have kidney or liver impairment

• Are pregnant or breastfeeding

• Consume alcohol frequently

• Have a history of heart failure or lactic acidosis

• Undergo any surgery or medical imaging requiring contrast dye

Patients with vitamin B12 deficiency should be monitored during prolonged metformin therapy.

Drug Interactions

The combination of sitagliptin phosphate and metformin hydrochloride tablets may interact with the following:

• Diuretics (e.g., furosemide) – may increase risk of lactic acidosis

• Insulin or sulfonylureas – may increase risk of hypoglycemia

• Cimetidine – may affect metformin elimination

• Iodinated contrast media – may increase the risk of acute renal failure

• Alcohol – enhances metformin’s effect on lactate metabolism, increasing lactic acidosis risk

What Drugs Interact with Sitagliptin and Metformin?

• ACE inhibitors (e.g., enalapril)

• NSAIDs (e.g., ibuprofen)

• Beta-blockers – may mask symptoms of hypoglycemia

• Ranolazine, dolutegravir, and vandetanib – can increase metformin concentration

• Digoxin – sitagliptin may slightly raise digoxin levels; monitor appropriately

Always inform your healthcare provider about all the medications, supplements, or herbal products you are taking.

Conclusion

GLISITAPTIN M KIT, containing sitagliptin phosphate 100 mg and metformin hydrochloride 1000 mg, offers a clinically proven solution for patients struggling with uncontrolled Type 2 Diabetes Mellitus. It effectively reduces blood glucose levels, improves insulin action, and lowers the risk of long-term diabetic complications.