GLISITAPTIN M 1000

GLISITAPTIN M 1000 is a prescription oral antidiabetic medication that combines two powerful agents — sitagliptin phosphate 50 mg & metformin hydrochloride 1000 mg — to help control high blood sugar in adults with Type 2 Diabetes Mellitus. This fixed-dose combination works through complementary mechanisms to enhance insulin response and reduce glucose production in the liver.

It is an effective treatment option when diet, exercise, and a single antidiabetic drug are not sufficient to manage blood sugar levels.

What is Sitagliptin Phosphate 50 mg & Metformin Hydrochloride 1000 mg?

• Sitagliptin phosphate is a DPP-4 inhibitor (dipeptidyl peptidase-4 inhibitor) that works by increasing levels of incretin hormones, which stimulate insulin release and reduce glucagon levels in the blood.

• Metformin hydrochloride 1000 mg is a biguanide that decreases hepatic glucose production and improves insulin sensitivity, thereby helping to lower blood glucose levels effectively.

Together, these agents offer synergistic glucose control in patients with Type 2 Diabetes.

Uses of Sitagliptin Phosphate & Metformin Hydrochloride Tablets

The key uses of sitagliptin phosphate 50 mg & metformin hydrochloride 1000 mg include:

• Treatment of Type 2 Diabetes Mellitus in adults

• As an adjunct to diet and exercise for better glycemic control

• For patients inadequately controlled with metformin alone

• Can be used in combination with other oral antidiabetic agents or insulin

Side Effects of GLISITAPTIN M 1000

While GLISITAPTIN M 1000 is generally well-tolerated, some patients may experience:

• Nausea or vomiting

• Diarrhea

• Abdominal discomfort

• Low blood sugar (hypoglycemia), especially when used with insulin or sulfonylureas

• Headache

• Respiratory infections (mild)

• Vitamin B12 deficiency with long-term metformin use

• Rare but serious: Lactic acidosis (seek immediate medical attention)

If any unusual symptoms occur, consult your doctor immediately.

Precautions Before Using GLISITAPTIN M 1000

• Inform your doctor if you have kidney problems, liver disease, or heart failure.

• Not recommended during pregnancy or breastfeeding unless advised by your physician.

• Avoid excessive alcohol intake while on metformin to reduce the risk of lactic acidosis.

• Monitor blood sugar levels regularly.

• Ensure adequate hydration during therapy.

• Do not skip meals, as this may increase the risk of hypoglycemia.

Drug Interactions

Several drugs can interact with sitagliptin phosphate & metformin hydrochloride tablets, affecting their safety or effectiveness:

What drugs interact with GLISITAPTIN M 1000?

• Diuretics (e.g., furosemide) – may increase the risk of dehydration

• Beta-blockers (e.g., atenolol) – may mask symptoms of low blood sugar

• Corticosteroids – may elevate blood sugar levels

• Thyroid medications – may interfere with glucose control

• Alcohol – increases the risk of lactic acidosis

• Contrast agents used in imaging procedures – may raise the risk of kidney issues and lactic acidosis (temporarily stop metformin before and after imaging tests as advised)

Always inform your doctor about all medications, supplements, or herbal products you are using.

Conclusion

GLISITAPTIN M 1000, combining sitagliptin phosphate 50 mg & metformin hydrochloride 1000 mg, is a clinically effective and well-tolerated treatment for Type 2 Diabetes. It helps achieve better glycemic control, especially in patients who are not well-managed on metformin alone. With regular use and a balanced lifestyle, it plays a key role in minimizing long-term diabetic complications.