GLIDAPAFLOZIN M 10/1000

GLIDAPAFLOZIN M 10/1000 is an advanced antidiabetic formulation that combines Dapagliflozin (10 mg) and Metformin Hydrochloride (1000 mg), two well-established agents in type 2 diabetes care. This fixed-dose combination works synergistically to control high blood sugar levels, improve insulin sensitivity, and reduce glucose reabsorption in the kidneys.

Designed for adults with type 2 diabetes mellitus, GLIDAPAFLOZIN M 10/1000 not only improves glycemic control but also supports weight management and reduces cardiovascular risk when combined with proper diet and exercise.

What is Dapagliflozin and Metformin Hydrochloride?

Dapagliflozin and Metformin Hydrochloride is a dual oral antidiabetic therapy used to treat type 2 diabetes mellitus.

• Dapagliflozin belongs to the class of SGLT2 inhibitors (sodium-glucose co-transporter 2 inhibitors). It reduces blood sugar by preventing glucose reabsorption in the kidneys, promoting its excretion via urine.

• Metformin Hydrochloride is a biguanide, which works by decreasing glucose production in the liver and enhancing insulin sensitivity in muscle cells.

Together, these agents provide complementary glucose-lowering effects, helping patients achieve better long-term glycemic control.

Uses of Dapagliflozin and Metformin Tablets

The combination of dapagliflozin and metformin is primarily used for:

• Managing type 2 diabetes mellitus in adults

• Reducing HbA1c (glycated hemoglobin) levels

• Supporting weight loss in overweight or obese diabetic patients

• Helping reduce cardiovascular complications in patients with type 2 diabetes

• Lowering the risk of hospitalization due to heart failure

• Delaying the progression of diabetic kidney disease

Note: This combination is not recommended for treating type 1 diabetes or diabetic ketoacidosis.

Side Effects of Dapagliflozin and Metformin

While generally well-tolerated, dapagliflozin and metformin hydrochloride may cause some side effects:

Common Side Effects:

• Nausea or stomach upset

• Diarrhea or abdominal discomfort

• Frequent urination (due to glucose excretion)

• Mild dehydration

• Headache

• Weight loss

Serious Side Effects (Rare but Possible):

• Lactic acidosis (a rare but serious complication of metformin)

• Genital yeast infections (especially in women)

• Urinary tract infections

• Hypoglycemia (when used with insulin or sulfonylureas)

• Low blood pressure or dizziness

If any side effects persist or worsen, consult your healthcare provider immediately.

Precautions Before Using Dapagliflozin and Metformin

Before starting GLIDAPAFLOZIN M 10/1000, take the following precautions:

• Inform your doctor if you have kidney or liver problems

• Avoid using if you have diabetic ketoacidosis or severe dehydration

• Tell your doctor if you have a history of urinary tract infections or genital infections

• Use cautiously in elderly patients due to risk of volume depletion

• Avoid alcohol consumption, which increases the risk of lactic acidosis

• Not recommended for pregnant or breastfeeding women unless prescribed

• Stay well-hydrated, especially during hot weather or strenuous exercise

What Drugs Interact with Dapagliflozin and Metformin?

Certain medications can interact with dapagliflozin and metformin hydrochloride, affecting their efficacy or increasing the risk of side effects.

Drugs That May Interact Include:

• Diuretics (e.g., furosemide): Can increase the risk of dehydration and low blood pressure

• ACE inhibitors / ARBs (e.g., enalapril, losartan): May enhance blood sugar-lowering effects and risk of kidney injury

• Insulin or sulfonylureas: Increases the risk of hypoglycemia

• Cimetidine: May raise metformin levels, increasing the risk of lactic acidosis

• Iodinated contrast agents (used in imaging): Avoid metformin around the time of imaging due to risk of kidney impairment

• NSAIDs (e.g., ibuprofen): Can impair kidney function when combined

Always inform your doctor about all prescription drugs, OTC medications, and supplements you are using.

Conclusion

GLIDAPAFLOZIN M 10/1000 offers a powerful dual mechanism for effective type 2 diabetes control by combining dapagliflozin and metformin hydrochloride in one tablet. With proven benefits in blood sugar regulation, weight control, and cardiovascular protection, it is an ideal option for patients seeking comprehensive diabetic management.

For optimal results, use under medical supervision along with a balanced diet, regular exercise, and routine glucose monitoring.

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