GLIDAPA PIO

GLIDAPA PIO is a combination oral antidiabetic medication used to manage Type 2 Diabetes Mellitus in adults. This formulation combines Dapagliflozin, a sodium-glucose co-transporter-2 (SGLT2) inhibitor, and Pioglitazone, a thiazolidinedione (TZD), to improve blood glucose control in patients who cannot achieve target levels with diet and exercise alone. It not only helps in lowering blood sugar levels but also provides cardiovascular and renal protection.

Key Ingredients:

• Dapagliflozin (10mg): An SGLT2 inhibitor that helps lower blood glucose by increasing glucose excretion through urine.

• Pioglitazone (15mg): A thiazolidinedione that enhances insulin sensitivity in muscle, fat, and liver tissues, improving glucose utilization.

Key Benefits:

• Helps in achieving better glycemic control in Type 2 Diabetes Mellitus.

• Reduces insulin resistance and enhances glucose uptake by peripheral tissues.

• Promotes urinary glucose excretion, aiding in blood sugar reduction.

• Supports weight management due to the glucose-lowering effect of dapagliflozin.

• Provides cardiovascular benefits by reducing the risk of heart failure hospitalization.

• Offers renal protection by reducing albuminuria and slowing kidney disease progression.

• Improves lipid profile and helps in managing metabolic syndrome components.

How Does It Work?

GLIDAPA PIO works through a dual mechanism of action:

• Dapagliflozin inhibits SGLT2 in the proximal renal tubules, reducing reabsorption of filtered glucose and increasing urinary glucose excretion, thereby lowering plasma glucose levels.

• Pioglitazone activates peroxisome proliferator-activated receptor-gamma (PPAR-γ), enhancing insulin sensitivity in adipose tissue, skeletal muscle, and the liver, leading to better glucose uptake and reduced hepatic glucose output.
  Together, they offer complementary benefits in managing blood sugar levels and addressing insulin resistance.

Directions for Use:

• Take GLIDAPA PIO exactly as prescribed by your healthcare provider.

• Usually taken once daily, with or without food, preferably at the same time each day.

• Do not crush or chew the tablet; swallow it whole with a glass of water.

• Follow your doctor’s advice on diet, exercise, and lifestyle modifications for optimal results.

• Regularly monitor your blood glucose levels as recommended by your physician.

• Do not stop or change the dosage without consulting your healthcare professional.

Side Effects:

• Common side effects may include urinary tract infections, genital infections, increased urination, weight gain (from pioglitazone), and edema (fluid retention).

• Possible gastrointestinal symptoms such as nausea, diarrhea, or stomach discomfort.

• Risk of hypoglycemia when combined with insulin or sulfonylureas.

• Rare but serious side effects include heart failure exacerbation, bone fractures, bladder cancer risk (associated with long-term pioglitazone use), and ketoacidosis (though rare).

• Inform your doctor immediately if you experience symptoms like shortness of breath, sudden weight gain, or painful urination.