GLICLAGLAZE M 80

GLICLAGLAZE M 80 is a fixed-dose combination medicine used in the management of Type 2 Diabetes Mellitus, designed for patients whose blood sugar levels are not adequately controlled on Metformin alone, or who need a more comprehensive dual-mechanism approach to glycemic control from the start of treatment.

The combination brings together two well-established, complementary anti-diabetic agents:

Gliclazide, a sulfonylurea, works by stimulating the beta cells of the pancreas to release more insulin into the bloodstream. This helps the body process circulating glucose more effectively, particularly benefiting patients whose pancreas still has some functional insulin-producing capacity.

Metformin Hydrochloride, a biguanide, works through a different mechanism — it reduces the amount of glucose the liver releases into the bloodstream and improves the sensitivity of body tissues (particularly muscle and fat cells) to insulin, allowing the insulin that is present to work more efficiently.

By combining a medicine that increases insulin availability (Gliclazide) with one that improves how effectively the body uses that insulin (Metformin), GLICLAGLAZE M 80 addresses blood sugar control from two complementary angles. This dual-action approach often achieves better glycemic control than either medicine used alone, while simplifying the treatment regimen into a single tablet rather than two separate prescriptions.

Product Information

Why GLICLAGLAZE M 80 Is Important

Type 2 diabetes is a progressive metabolic condition, and for a significant number of patients, blood sugar control with a single medicine — particularly Metformin alone — becomes insufficient as the disease advances or as insulin resistance increases over time. Consistently high blood sugar levels, if left inadequately managed, substantially raise the risk of serious long-term complications, including damage to the eyes, kidneys, nerves, and cardiovascular system.

GLICLAGLAZE M 80 plays an important role because it:

• Offers dual-mechanism blood sugar control, combining increased insulin release with improved insulin sensitivity
• Provides a practical treatment intensification option for patients whose diabetes is not adequately controlled on Metformin monotherapy
• Simplifies treatment by combining two medicines into one tablet, reducing pill burden and supporting better adherence
• Supports better long-term HbA1c control, which is directly linked to reduced risk of diabetes-related complications
• Offers a well-established, extensively used combination in diabetes management, giving physicians a reliable option backed by long clinical experience

Because this combination involves two distinct drug classes, each with its own considerations around hypoglycemia risk, kidney function, and other health factors, it requires careful physician oversight to ensure it is appropriately matched to each patient's individual diabetes profile.

Key Benefits

• Dual-action mechanism — combines increased insulin secretion with improved insulin sensitivity for more effective blood sugar control
• Reduces pill burden by combining two anti-diabetic medicines into a single tablet
• Supports better long-term HbA1c and glycemic control, reducing risk of diabetes-related complications
• Useful intensification option for patients not adequately controlled on Metformin alone
• Well-established combination with a long track record of clinical use in Type 2 diabetes management
• Backed by WHO-GMP certified manufacturing, ensuring consistent tablet quality and dosing accuracy

Precautions

• Should be used only under medical supervision, with regular monitoring of blood glucose, HbA1c, and kidney function
• Caution advised in patients with kidney impairment, as Metformin use requires dose adjustment or avoidance based on kidney function levels
• Risk of hypoglycemia (low blood sugar) exists, mainly due to the Gliclazide component — patients should be aware of symptoms (sweating, shakiness, confusion, dizziness) and how to respond
• Should be used cautiously in patients with liver disease, heart failure, or conditions predisposing to lactic acidosis (a rare but serious risk associated with Metformin)
• Alcohol should be avoided or limited, as it can increase the risk of hypoglycemia and lactic acidosis
• Temporary discontinuation may be required before procedures involving contrast dye (imaging scans) or major surgery — inform all treating doctors that this medicine is being taken
• Not recommended during pregnancy or breastfeeding unless specifically advised by a physician
• Elderly patients may be more sensitive to hypoglycemia and should be monitored closely
• Meals should not be skipped while on this medicine, to reduce the risk of low blood sugar episodes
• Inform the doctor of all other medications, as several drug classes can interact with components of this combination

Side Effects

• Gastrointestinal discomfort — nausea, bloating, or diarrhea (particularly with the Metformin component, often improving over time)
• Hypoglycemia (low blood sugar) — more likely if meals are skipped or delayed
• Metallic taste in the mouth
• Loss of appetite
• Headache
• Dizziness
• Rarely: lactic acidosis (a serious condition requiring emergency care — symptoms include severe muscle pain, difficulty breathing, unusual tiredness, and stomach discomfort)
• Rarely: allergic skin reactions

Frequently Asked Questions

1. Where can I buy Gliclazide and Metformin Hydrochloride Tablets online?
You can buy Gliclazide and Metformin Hydrochloride Tablets through licensed online pharmacies or authorized pharmaceutical suppliers in India. Verify the manufacturer, strength, batch number, expiry date, and packaging before purchasing.

2. What is the price of Gliclazide and Metformin Hydrochloride Tablets?
The price may vary depending on the brand, strength, pack size, manufacturer, seller, taxes, and delivery charges. Check the current price with a licensed pharmacy or authorized supplier.

3. Can I order Gliclazide and Metformin Hydrochloride Tablets online?
Yes, these tablets can be ordered online where legally available. They are generally prescription medicines, so a valid prescription may be required. Purchase only through a licensed pharmacy or authorized supplier.

4. Is Gliclazide and Metformin Hydrochloride Tablets available from Steris Healthcare?
Availability depends on Steris Healthcare's current product range and stock status. Contact Steris Healthcare or an authorized distributor to confirm the available strengths, pack size, price, and ordering details.

5. What is Gliclazide and Metformin Hydrochloride Tablets used for?
Gliclazide and Metformin Hydrochloride Tablets are used to help control blood glucose levels in people with type 2 diabetes mellitus, along with a suitable diet and regular physical activity. The two medicines work through different mechanisms to improve blood sugar control.

6. What is the composition of Gliclazide and Metformin Hydrochloride Tablets?
These tablets contain two active ingredients: Gliclazide and Metformin Hydrochloride. The exact strength and formulation may vary depending on the specific product.

7. Is a prescription required?
Yes, Gliclazide and Metformin Hydrochloride Tablets are generally prescription medicines and should be used under medical supervision. Your doctor will determine the appropriate strength and dosage according to your individual treatment needs.

8. How should Gliclazide and Metformin Hydrochloride Tablets be taken?
Take the tablets exactly as prescribed by your doctor. They are commonly taken with meals to help reduce stomach-related side effects and manage blood glucose effectively. Swallow the tablet with water and do not change the dose or stop treatment without medical advice.

9. What should I know before buying Gliclazide and Metformin Hydrochloride Tablets?
Before buying, verify the exact strengths, formulation, manufacturer, batch number, expiry date, packaging, and storage instructions. Inform your doctor about kidney or liver problems, severe infections, alcohol use, pregnancy or breastfeeding, and all medicines or supplements you take. Gliclazide may cause low blood sugar in some patients.

10. How can I order Gliclazide and Metformin Hydrochloride Tablets online?
To order these tablets online, choose a licensed pharmacy or authorized supplier, select the prescribed strength and pack size, provide a valid prescription if required, verify the product and expiry details, and complete the purchase.