GLICLAGLAZE M 80

GLICLAGLAZE M 80 is a powerful oral anti-diabetic formulation that combines Gliclazide and Metformin Hydrochloride, two widely used medications for the effective management of type 2 diabetes mellitus. This dual combination works synergistically to control blood sugar levels, reduce insulin resistance, and prevent diabetes-related complications.

What is Gliclazide and Metformin Hydrochloride Tablets?

Gliclazide and Metformin Hydrochloride Tablets are a combination of:

• Gliclazide: A sulfonylurea that stimulates the pancreas to release more insulin, thereby lowering blood sugar

• Metformin: A biguanide that reduces hepatic glucose production and improves insulin sensitivity in the body

This combination provides a comprehensive approach to glycemic control, targeting both insulin deficiency and resistance.

Uses of Gliclazide and Metformin Tablets

GLICLAGLAZE M 80 is primarily used for:

• Managing blood glucose levels in adults with type 2 diabetes mellitus

• Reducing the risk of long-term complications such as nerve damage, kidney failure, and heart disease

• Helping improve insulin response in patients who are overweight or obese

• Supporting patients who do not achieve adequate control with single therapy alone

This fixed-dose combination is especially beneficial for patients requiring dual therapy to achieve better glycemic targets.

Side Effects of Gliclazide and Metformin

Though generally well-tolerated, some patients may experience side effects such as:

• Nausea, vomiting, or stomach upset

• Metallic taste in the mouth

• Dizziness or headache

• Hypoglycemia (low blood sugar), especially if meals are skipped

• Rarely, lactic acidosis (with metformin), a serious but uncommon condition

• Weight gain (with gliclazide)

It is important to monitor blood sugar regularly and follow dietary advice to minimize side effects.

Precautions Before Using Gliclazide and Metformin

Before starting GLICLAGLAZE M 80, inform your doctor if you:

• Have kidney, liver, or heart disease

• Consume alcohol frequently

• Are pregnant or planning pregnancy

• Are undergoing surgery or radiological imaging with contrast agents

• Have a history of hypoglycemia or lactic acidosis

Avoid excessive alcohol intake, stay well-hydrated, and do not skip meals while on this medication.

Drug Interactions: What Drugs Interact with Gliclazide and Metformin?

Certain drugs may interact with Gliclazide and Metformin, potentially affecting how the medication works or increasing side effect risks:

• Beta-blockers (may mask symptoms of hypoglycemia)

• ACE inhibitors and ARBs (may enhance blood sugar-lowering effects)

• Diuretics and steroids (may increase blood sugar levels)

• Contrast agents used in imaging (may increase risk of lactic acidosis)

• Alcohol (increases risk of lactic acidosis and hypoglycemia)

Always disclose your current medications, including over-the-counter drugs and supplements, to your doctor.

Conclusion

GLICLAGLAZE M 80 offers a reliable and clinically proven solution for managing type 2 diabetes. With the combined strength of Gliclazide and Metformin Hydrochloride Tablets, it delivers comprehensive control over blood sugar levels while helping reduce the risk of long-term diabetic complications.

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