FLUROMILAST 500

Fluromilast 500 is a prescription medicine containing Roflumilast (500 mcg), a selective Phosphodiesterase-4 (PDE4) inhibitor. It's specifically used in the long-term management of severe Chronic Obstructive Pulmonary Disease (COPD), particularly in patients who experience frequent flare-ups (exacerbations) despite other standard treatments.

In simple terms: COPD involves ongoing airway inflammation that gradually damages lung tissue and narrows airways, making breathing progressively more difficult. Unlike bronchodilator inhalers, which work by physically relaxing airway muscles, Roflumilast works differently — it targets the underlying inflammatory process at a cellular level. By inhibiting the PDE4 enzyme, it helps reduce the inflammatory signals that drive ongoing lung tissue damage and flare-up frequency in COPD.

Product Information

Why Fluromilast 500 Is Important

Chronic Obstructive Pulmonary Disease is a significant and growing health burden in India, driven by factors like tobacco smoking, indoor and outdoor air pollution, occupational dust exposure, and the widespread use of solid fuels for cooking in many households. For patients living with severe COPD, frequent flare-ups aren't just uncomfortable — they're a major driver of hospitalization, declining lung function, and reduced quality of life over time. This is exactly where Roflumilast-based treatment like Fluromilast 500 plays an important role.

Here's why this medicine holds real clinical significance:

• India carries a substantial COPD burden. With high rates of smoking, air pollution exposure in major cities, and biomass fuel use in rural households, COPD affects a large number of Indian adults, often diagnosed only after significant lung function has already been lost.
• Frequent exacerbations accelerate disease progression. Each COPD flare-up can cause additional, sometimes irreversible, lung damage. Reducing how often these episodes occur is one of the most meaningful ways to slow long-term disease progression and preserve remaining lung function.
• It addresses inflammation directly, complementing bronchodilators. While inhalers manage airway muscle tightness and provide symptom relief, they don't directly target the underlying inflammatory processes driving COPD progression. Roflumilast's anti-inflammatory mechanism offers a complementary approach for appropriate patients.
• It's specifically targeted at high-risk patients. Roflumilast isn't intended for all COPD patients — it's specifically studied and prescribed for those with severe disease and a history of frequent exacerbations, making it a targeted tool for a particularly vulnerable patient group.
• Reducing hospitalizations matters enormously for patients and families. COPD exacerbations often require hospital admission, which is physically taxing for patients and creates significant financial and caregiving burden for families. Medicines that meaningfully reduce exacerbation frequency have real, practical impact beyond the clinical data.

For someone searching "roflumilast" after a pulmonologist recommends it as an add-on therapy for frequent COPD flare-ups, understanding this targeted, anti-inflammatory mechanism helps clarify why it's being added to an existing inhaler regimen rather than replacing it.

Key Benefits 

Precautions 

Roflumilast requires certain precautions given its systemic effects. Inform your doctor before starting if you have:

• Liver disease, particularly moderate to severe impairment — Roflumilast is processed by the liver and may not be suitable in significant liver dysfunction
• Low body weight or unexplained weight loss — Roflumilast has been associated with weight loss in some patients, so baseline weight should be monitored, especially in patients who are already underweight
• History of depression, anxiety, or other mood disorders — Roflumilast has been associated with psychiatric side effects, including mood changes, in some patients; this requires careful discussion with your doctor, especially if you have a prior history
• History of suicidal thoughts or behavior — this is an important disclosure to make to your doctor, as PDE4 inhibitors have been linked to rare reports of worsening mood or suicidal ideation
• Severe immunological conditions or those on immunosuppressive therapy — should be discussed with your doctor
• Pregnancy or breastfeeding — Roflumilast is generally not recommended unless specifically advised by your doctor after careful risk-benefit assessment
• Use in patients under 18 — not typically established for pediatric COPD use

Possible Side Effects

Roflumilast has a distinct side-effect profile that's important to understand clearly, as some effects — while manageable — require attentive monitoring.

Commonly reported (often mild to moderate, sometimes improving with continued use):

• Diarrhea
• Weight loss / reduced appetite
• Nausea
• Headache
• Back pain
• Sleep disturbances (insomnia)
• Dizziness

Less common, but important to monitor closely:

• Mood changes, including new or worsening anxiety, depression, or unusual behavior — requires prompt medical discussion
• Thoughts of self-harm or suicide — seek immediate medical attention if these occur; do not wait for a scheduled appointment
• Significant, unintended weight loss — should be reported to your doctor, who may recommend weight monitoring throughout treatment
• Signs of an allergic reaction (rash, swelling, difficulty breathing)
• Palpitations or irregular heartbeat

Frequently Asked Questions 

1. Where can I buy Roflumilast online?
You can buy Roflumilast through licensed online pharmacies or authorized pharmaceutical suppliers in India. Verify the strength, manufacturer, batch number, expiry date, and packaging before purchasing.

2. What is the price of Roflumilast?
The price of Roflumilast may vary depending on the strength, brand, pack size, manufacturer, seller, taxes, and delivery charges. Check the current price before placing an order.

3. Can I order Roflumilast online?
Yes, Roflumilast may be ordered online through licensed pharmacies or authorized suppliers where legally available. It should be used according to a healthcare professional's instructions.

4. Is Roflumilast available from Steris Healthcare?
Availability from Steris Healthcare depends on its current product range and stock status. Contact Steris Healthcare or an authorized supplier to confirm availability, strength, pack size, and ordering details.

5. What is Roflumilast used for?
Roflumilast is a phosphodiesterase-4 (PDE4) inhibitor used to reduce the risk of COPD exacerbations in certain patients with severe COPD associated with chronic bronchitis and a history of exacerbations. The specific indication depends on the formulation and prescribed use.

6. What is the composition of Roflumilast?
The active ingredient is Roflumilast. The exact strength and inactive ingredients depend on the specific formulation and should be checked on the product packaging.

7. Is a prescription required?
Roflumilast is a prescription medicine and should be used under the supervision of a qualified healthcare professional.

8. How should Roflumilast be taken?
Take Roflumilast exactly as prescribed. It is generally taken once daily, with or without food, but follow the instructions for your specific product. Do not change the dose or stop treatment without medical advice.

9. What should I know before buying Roflumilast?
Before buying, verify the prescribed strength, composition, manufacturer, batch number, expiry date, and packaging. Tell your healthcare professional about liver disease, significant weight loss, depression or other mental-health symptoms, and all medicines or supplements you take.

10. How can I order Roflumilast online?
You can order Roflumilast through a licensed online pharmacy or authorized pharmaceutical supplier where legally permitted. Select the prescribed strength and pack size, provide a prescription if required, and verify the product and expiry details before completing your order.